What are the symptoms of primary lateral sclerosis at first?

In the early stages of primary lateral cord malacia, there are impaired mobility, limb incoordination, stiffness and weakness, and difficulty walking. If nerve damage is significant, the patient may have spasms and stiffness in the upper limbs and limbs, and examination may suggest signs of upper neuronal injury, such as increased limb muscle tone, tendon hyperreflexia, and positive pathological signs.

1. The first one is that there will be movement disorders, and patients with amyotrophic lateral sclerosis will have spastic paralysis and cerebellar ataxia. In the early stages of amyotrophic lateral sclerosis, patients may experience clumsiness and tremors in their hands, stumble and fall in their legs, and sometimes stutter when speaking.

2. Then there will be cranial nerve dysfunction, the patient will have vision loss caused by optic neuritis, as well as the dark spot in the center of the visual field, and the patient's pupil irregularity or narrowing plus nystagmus is also a common phenomenon. However, there will also be a small number of patients with trigeminal neuralgia.

3. There will be sensory impairment, which is often caused by spinal cord lesions, often with pinprick and numbness, banding and burning, or abnormal pain. Pain often occurs in the back, lower legs, and arms, and patients may also have pseudobulbar palsy, with varying degrees of speech and even vocal cord paralysis.

In general, this disease is more common in the elderly, and there are many genetic factors, usually the upper limbs are damaged, spasms and weakness and other symptoms, and then slowly spread to the lower limbs, resulting in the deterioration of the condition, this disease is also caused by defects in the nerve center, so in this disease. During the course of the disease, the patient's mood changes greatly, especially when the emotional level is high, and there may be strong crying and laughing.

1 Pinyin 2 English references.

3 Classification of diseases.

4 Overview of the disease.

5 Disease description.

6 Signs and symptoms.

7 Diagnostic tests.

8 Related Sources.

Attached: 1 **Acupuncture points of primary lateral sclerosis.

yuán fā xìng cè suǒ yìng huà

primary lateral sclerosis

Neurology. Primary lateral sclerosis is a motor neuron disease characterized by predominantly corticospinal tract involvement, with spastic paraplegia and normal sensation as the main manifestation. The disease belongs to the category of impotence syndrome in traditional Chinese medicine, which is caused by wind and stasis blocking the muscles and veins, liver and kidney deficiency, and dystrophy of the muscles and veins.

It is more common in men aged 31 to 60 years; The onset is insidious and the progression is slow.

Clinical manifestations: (1) Spastic paraplegia: symmetrical weakness and stiffness of both lower limbs, with a spastic gait when walking, and gradually involving both upper limbs.

In general, muscle tone is increased, tendon reflexes are hyperactive, lower limbs are more obvious, and pathological reflexes are positive. Urinary incontinence may occur in the later stages. (2) No muscle atrophy and fasciculations.

3) Objective sensation is normal, and unconscious intelligence changes.

Ancillary examinations: (1) Cerebrospinal fluid examination is mostly normal. (2) Electromyography examination showed neurogenic damage.

Differential diagnosis: 1 Syringomyelia: with segmental ** dissociation phenomenon, spinal aerogram shows symmetrical enlargement of the spinal cord.

2 Spinal cord tumors: often radicular pain or fascicularity disorder, often asymmetrical, cerebrospinal fluid examination protein content is elevated, myelography and MRI can help to identify.

General**:1 Strengthen nutrition and give a high-protein and high-vitamin diet. 2 Use a foot brace to maintain proper movement.

Rarely, selective damage to the corticospinal cord binding, resulting in supralimb motor neuron dysfunction.

1) onset in middle age or later; The first symptom is symmetrical spastic weakness in both lower limbs, which progresses slowly and gradually spreads to both upper limbs, with increased muscle tone in the limbs, tendon hyperreflexia, and pathological signs, no muscle atrophy, no fasciculation, and normal feeling;

2) Pseudobulbar palsy in cortical bulbar tract degeneration, accompanied by emotional instability, forced crying and laughter;

3) Most of the disease is slowly progressive, and long-term survival is occasionally reported.

1. Neuroelectrophysiology: EMG shows typical neurogenic changes. fibrillation potential, positive propagation, and sometimes fasciculation potential at rest; When the small force contraction, the time limit of the unit potential of the movement increases, the amplitude increases, the multiphase wave increases, and the vigorous contraction presents a simple phase.

Nerve conduction velocities are normal. Motor evoked potentials help identify upper motor neuron damage.

2. Muscle biopsy: helpful for diagnosis, but non-specific, neurogenic amyotrophy in the early stage, and myogenic amyotrophy in the late stage under light microscopy is not easy to distinguish.

3. Others: blood biochemistry and CSF examinations were mostly abnormal, creatine phosphokinase (CK) activity could be mildly abnormal, and MRI could show that the affected spinal cord and brainstem atrophy became smaller in some cases.

Neurology, Fifth Edition.

Fengchi Pinyin: fēngchí English: fēngchígb20; fēngchí;g20;GB20 Overview: Wind Pool: 1Small. Hot House.

Introduction: Many people do not know what lateral sclerosis is, it is a chronic, progressive neurodegenerative disease, which is difficult to develop after an attack, and when the disease becomes more severe, it will cause the patient to have dyspnea or dysphagia, which may be life-threatening, and will be accompanied by different pains. This disease can not be **, and there will be many adverse reactions after the disease, such as skeletal muscle weakness, atrophy, etc., the general age of onset is between 30 and 60 years old, and there are more men.

Next, let's analyze with you, what are the effects of the symptoms of lateral sclerosis?

Lateral sclerosis, also commonly known as ALS, is a chronic, progressive degenerative disease that affects upper and lower motor neurons, as well as innervated trunks, limbs, etc. It is a type of motor neuron disease that is usually sporadic and familial. When patients have lateral sclerosis, they are generally weak and stiff in the lower limbs, which is more difficult in the process of walking, and slowly affects both upper limbs.

When patients have symptoms of lateral sclerosis, they are more likely to be agitated, and memory loss, including cognitive and intellectual decline, will cause dementia in the advanced stage, and language impairment, which may lead to inability to speak, vision loss, and facial paralysis. Patients may also often feel pins and needles or numbness, which is common in the back, lower legs, and upper limbs. In the early stage, people will become more and more clumsy, easy to fall, and at the same time begin to become wooden, and some patients will have symptoms of frequent urination, urgency, and urinary incontinence in the later stage.

Therefore, the impact on people's normal life is very large.

In the early stage of diagnosis, it is necessary not only to do a neurological examination, but also to cooperate with imaging examination and electromyography examination, a series of tests of serum special antibodies, nerve conduction velocity, and muscle biopsy in special cases.

Patients with lateral sclerosis present primarily with muscle weakness, amyotrophy, and pyramidal tract signs, and generally do not present with sensory and urinary and stool disturbances. Most patients begin in one upper extremity, but some may also begin in the lower extremity, and fasciculations may occur at the onset of the disease. Generally speaking, most of the distal muscle weakness is more obvious than the proximal end, when the disease begins to occur in the upper limbs, most of them first manifest as inflexible finger movements and weakened strength, and may be accompanied by ipsilateral difficulty in wrist extension, and some patients can also begin to have proximal weakness of the entire upper limb, followed by atrophy of small muscles of the hand such as thenar and vermiform, and can gradually develop into the forearm, upper arm and shoulder girdle muscle.

Extensor weakness is usually more pronounced than flexors, and patients may gradually develop spastic paralysis of the lower extremities, scissor gait, tendon hyperreflexia, and bulbar paralysis in advanced patients. Patients may present with dysarthria, slurred speech, and may have difficulty swallowing and chewing.

The body may experience weakness in the limbs, dizziness, hot-headedness, loss of appetite, and lack of sleep. So when we have this situation, we must go to the hospital to do the corresponding **.

It affects people's muscles, affects people's lives, affects their own walking, makes the body have no strength, and makes it impossible for them to do things.

Primary lateral sclerosis is a type of motor neuron disease. The so-called motor neuron disease is ALS. Once the disease has developed, there is currently no particularly effective way to reverse it.

**Methods are mainly: first, for ****; second, symptomatic**; Third****.

In terms of amyotrophic lateral sclerosis, including primary lateral sclerosis, it may be related to the toxic effects of excitatory amino acids or free radical oxidation, and anti-excitatory amino acid toxicity, neurotrophic factors, anti-apoptosis and antioxidant free radical scavengers can be taken.

In terms of symptoms, patients with primary lateral sclerosis may have dysphagia and can adopt a semi-liquid diet; In severe cases, nasogastric fluids or gastrostomy can be used; When dyspnea occurs, assisted breathing is used; When walking is unsteady, gait training should be carried out.

In addition, a series of acupuncture, gait training, swallowing function training, etc. can be carried out.

Amyotrophic lateral sclerosis is a rare disease and a chronic disease. This is due to an invasion or mutation of the patient's nervous system, which causes the patient's muscles to atrophy. The main manifestation of lateral sclerosis is muscle weakness in the patient's bones, and in severe cases, atrophy may occur, and the age of onset is usually between 30 and 60 years old.

However, there are more males than females. A little bit of non-atrophic lateral sclerosis can only help patients with remission, but it can't**. What is non-atrophic lateral sclerosis, which may be caused by genetic factors.

Of course, it can also be due to other factors that lead to amyotrophic lateral sclerosis.

Genetic factorsFor people with non-atrophic lateral sclerosis, the cause of the problem may be genetic. According to medical studies, some cases suggest that non-atrophic lateral sclerosis is hereditary, but in most cases no definitive ** has been found. In most cases, genetic factors are primarily related to reactions.

The next generation of people with non-amyotrophic lateral sclerosis and their offspring may have non-amyotrophic lateral sclerosis, which is a very important factor. Therefore, prenatal care should be done before childbirth so that prenatal diagnosis can better prevent the occurrence of diseases.

Motor neuron disease symptoms, duration, and degree of onset are related to the degree of right ventricular duct obstruction and whether the ductus arteriosus is closed. It is common to have a large number of capillaries on the surface, such as the lips, nail beds, bulbar conjunctiva, etc. Due to the decrease in oxygen in the blood and the lack of function, shortness of breath and cyanosis worsen if there are activities such as crying, mood, fatigue, coldness, etc.

Squatting is common in children. When they walk and play, they tend to actively cringe for a moment. During contraction, it reduces blood return, reduces cardiac load, increases internal circulatory resistance, reduces right-to-left shunt, and temporarily relieves hypoxia symptoms.

Children can't walk, and they usually like adults holding them up and bending their legs.

Early symptoms of amyotrophic lateral sclerosis include muscle weakness, which usually occurs in both the upper and lower extremities. In addition, some patients will present with slurred arthria, muscle atrophy, and some patients will also have limb numbness, limb pain, and even choking on drinking water, and these symptoms will affect the patient's cervical spinal cord, lumbar cord and medulla oblongata. The cause of the disease is not fully understood, but in addition to genetic factors, there are also theories of excitotoxicity, oxidative stress, and autoimmunity, which have long been thought to be related to the toxic effects of certain metal elements on neurons.

The disease is generally delayed in the development of the disease, and the patient will gradually lose the ability to live on his own, so at this time, the patient should be taken care of psychologically and in life, and corresponding help should be provided.

The initial symptoms of lateral sclerosis are weakness and throbbing of the muscles. Lateral sclerosis, also known as amyotrophic lateral sclerosis, is a motor neuron disease that begins in most patients in one upper limb and may also begin in the lower extremity, where fasciculations may occur. When the disease begins in the upper limbs, most of the patients first manifest as inflexible finger movements and weakened strength, and some patients will have weakness of the entire proximal upper limbs, followed by atrophy of small muscles of the hand such as thenar and termiaris muscles.

Lateral choromalacia, also known as active neuron disease, is a chronic condition. The clinical characteristics of this disease are: insidious onset, selective exacerbation, the key appearance is distal limb muscle atrophy, lack of strength, hypertonia, fasciculation, difficulty in moving, bulbar numbness, dysarthria, choking on eating, breathing and swallowing disorders, hyperreflexia and positive pathological features.