What are the early manifestations of MND?

There are two main types of early symptoms of motor neuropathy, one is weakness and the other is muscle beating.

Motor neuropathy is divided into upper motor neuron and lower motor neuron, upper motor neuron is mainly the apoptosis of motor neurons in the cerebral cortex, the main symptom is muscle weakness and muscle tone, but muscle tone is often not obvious, so that patients feel more muscle weakness. The second is paralysis of lower motor neurons, which is mainly due to apoptosis of anterior horn cells. Due to the wide distribution of anterior horn cells, the early weakness is not obvious, and the early manifestations are often muscle beating and rapid tremor.

Therefore, the early manifestations are often one is weakness, one is rapid tremor is more common, others are like some special parts of motor neuron disease, such as brainstem motor neuron disease, it can be manifested as crooked corners of the mouth, with facial paralysis as a manifestation, if it is a motor neuron disease of the throat, it is mainly manifested as dysphagia, dysphonia, tongue muscle atrophy, with these symptoms as the early manifestation, so in general it is manifested as weakness and rapid tremor, However, it is also necessary to further identify according to different parts.

MND can manifest as weakness and atrophy of the limbs, clumsiness and weakness of finger movements, muscle weakness and atrophy over the course of the disease, extending to the trunk and neck, and finally involving the facial and throat muscles. Patients may have bulbar paralysis, mostly in the late stage, the tongue muscles are first involved, manifested as tongue muscle atrophy, fasciculation, and tongue protrusion weakness, followed by pharyngeal, laryngeal, and masticatory muscle atrophy and weakness, resulting in the patient's slurred arthria, dysphagia, chewing weakness, and the orbicularis oculi muscle in the facial muscle is more obviously involved. There is often a pattern of disease progression in MND, usually from the upper extremity that is first affected, then to the contralateral upper extremity, to the ipsilateral lower extremity, to the contralateral lower extremity, and finally to the bulb involvement.

Motor neuron disease can be life-threatening, mostly within 3 to 5 years, death from respiratory muscle paralysis or lung infection, so motor neuron disease is more harmful. You can come to Beijing Renxuan Traditional Chinese Medicine to find Sheng Jinqiangfu**, and through one-to-one conditioning of Yiyuan Muscle Formula, the patient's symptoms can be improved.

Motor neuron disease is a neurodegenerative disease that primarily affects the motor system and not the sensory system. Motor neuron disease (MND) also invades upper and lower motor neurons, and often begins with weakness of the small muscles in one hand, accompanied by atrophy, and gradually progresses to other limbs, eventually affecting the respiratory and swallowing muscles, causing dyspnea and swallowing.

Motor neuron disease often progressively worsens, the course of the disease is about 3-5 years, you can come to Beijing Renxuan TCM to find Sheng Jinqiangfu**, through Yiyuan Muscle Formula one-to-one conditioning, can improve the patient's symptoms.

Common symptoms: muscle weakness, muscle atrophy, and fasciculations are manifestations of lower motor nervous system involvement; Hypertonia, hyperreflexia, and positive pathological signs are the main manifestations of upper motor nervous system involvement. Common symptoms:

Muscle weakness, muscle atrophy, and fasciculations are manifestations of lower motor nervous system involvement; Hypertonia, hyperreflexia, and positive pathological signs are the main manifestations of upper motor nervous system involvement.

The first will be the symptoms of weakness of the limbs, and there will also be stiffness of the limbs, the second will also appear some symptoms of muscle atrophy, and the third will also appear that the speech is slurred, and there will also be the symptoms of difficulty swallowing.

Motor neuron disease (MND) is a chronic progressive neurodegenerative disease that is characterized by upper and lower motor neuron damage This disease is often caused by stress, infection, and genetics What are the more common early symptoms of this disease?

1 Amyotrophic lateral sclerosis: Usually one or both fingers are inflexible, the small muscles of the hand are atrophied, and the hand can be eagle claw-shaped With the continuous development of the disease, it may gradually expand to the trunk and neck, and may even involve the facial muscles and throat muscles There are many times tremors in the parts involved, often accompanied by numbness and weakness.

2. Upper and lower motor nerve involvement: there may be clumsiness and stiffness of fine motor skills, decreased muscle strength, spasms, atrophy, tremors and other conditions in the limbs, and sometimes even some light work cannot be completed independently.

3 Muscle atrophy: Most people may experience muscle atrophy, which often brings a lot of harm, making the hand inflexible and weak, and usually starts with a finger that is removed, and then gradually affects the entire upper or lower limbs.

The early symptoms of MND include fatigue and weakness, exercise intolerance, sleep disturbance, emotional instability, and even poor swallowing of food and drink.

There are many types of motor neuron disease, which can be roughly divided into two aspects:

Clause. 1. Upper motor neuron disease;

Clause. 2. Lower motor neuron disease.

Symptoms caused by upper motor neuron disease are affective disorders, such as forced crying, forced laughter, increased muscle tone, pyramidal tract signs, or muscle spasms; Lower motor neuron disease directly causes muscle atrophy and decreased muscle strength, such as weakness and muscle atrophy of the limbs.

The early symptoms of MND are relatively mild, and there are no obvious typical symptoms, such as fatigue and weakness, exercise intolerance, sleep disorders, emotional instability, emotional disorders, and even eating and drinking that is not smooth, or muscle cramps and frequent muscle beating, etc., are all early symptoms.

Motor neuron disease usually has an insidious onset and a slow progression. Due to the different locations of injury, the clinical manifestations are different combinations of symptoms such as muscle weakness, muscle atrophy, and bulbar paralysis. In many cases, one type of presentation is present, followed by another, and finally ALS.

As a result, it can sometimes be difficult to determine which type it belongs to in the early stages of the disease.

1. Typical symptoms.

1. Amyotrophic lateral sclerosis: The common first symptom is clumsiness and weakness of one or both fingers, followed by atrophy of small finger muscles, which gradually develops to the muscles of the forearm, upper arm and shoulder. As the disease progresses, muscle weakness and atrophy extend to the trunk and neck, and eventually to the facial and laryngeal muscles.

In a few cases, muscle atrophy and weakness begin in the lower extremities or trunk. Fasciculations are often evident in the affected area.

2. Progressive amyotrophy: The common first symptom is atrophy and weakness of small muscles in one or both hands, which gradually affects the muscles of the forearm, upper arm and shoulder. Affected muscles are markedly atrophied, muscle tone is reduced, and muscle tremors may be seen.

3. Progressive bulbar paralysis: the main manifestations are progressive slurred articulation, dysphagia, choking on drinking water, and weakness in chewing. The tongue muscles are obviously atrophied, and there are fasciculations, and the lip muscles and throat muscles are atrophied.

This type of disease progresses rapidly, and most of them die within 1 to 2 years due to respiratory muscle paralysis or lung infection.

4. Primary lateral sclerosis: the common first symptom is symmetrical stiffness and fatigue of both lower limbs, and walking with a scissor gait. Progresses slowly and gradually affects both upper extremities. There is usually no muscle atrophy and fasciculations, and no sensory deficits. This type progresses slowly and can survive for a long time.

2. Other symptoms.

A small percentage of patients with motor neuron disease have manifestations outside the motor system, such as dementia, paresthesia, and urinary and urinary dysfunction, and a small number of patients have extraocular muscle movement disorders.

Symptoms of motor neuron disease, 75% of the initial symptoms of motor neuron disease of the extremities, 25% of patients develop bulbar symptoms. The earliest symptoms are asymmetrical weakness or slurred speech in the limbs. Diseases of the upper limbs often occur in the shoulder.

Sometimes, distal muscle weakness is more pronounced after a minor focal injury. It manifests itself as weakness. About 35% of patients start with the upper limbs and about 40% start with the lumbar spine.

Sensory symptoms are usually distal paresthesias and numbness, present in approximately 10% of patients, and nearly 50% of patients with MND have significant painful symptoms. In general, motor neuron disease is called primary lateral sclerosis if the lesion is predominantly of higher motor neurons; If the lesion predominates lower motor neurons, it is called progressive spinal muscular atrophy.