What causes chronic kidney failure? What are the reasons?

Chronic renal failure has the following:

1) Glomerular lesions: primary and secondary glomerulonephritis (such as IgA nephropathy, focal segmental glomerulosclerosis, diabetic nephropathy, hypertensive arteriolar sclerosis, lupus nephritis, etc.);

2) Tubulointerstitial lesions (chronic pyelonephritis, chronic uric acid nephropathy, obstructive nephropathy, drug-induced nephropathy, etc.);

3) renal vascular disease;

4) Hereditary kidney disease (such as polycystic kidney disease, hereditary nephritis), etc.

The most common causes of chronic renal failure are: obstructive nephropathy, such as ureteral obstruction; Reflux nephropathy, urinary tract stones, etc. Vascular nephropathy, such as hypertensive disease, renovascular hypertension, renal arteriolar sclerosis, etc.

chronic glomerulonephritis, such as IgA nephropathy, membranoproliferative glomerulonephritis; Focal segmental sclerosing glomerulonephritis and mesangial proliferative glomerulonephritis, etc. Systemic diseases, such as lupus nephritis, vasculitis, kidney damage, multiple myeloma, etc.

Although acute kidney failure is sometimes caused by a condition other than kidney disease, chronic kidney failure is almost always caused by kidney disease.

Primary nephropathy, a disease of the kidneys itself, accounts for more than half of the cases, and may be influenced by the increase in the number of diabetic nephropathies, which progresses from diabetic nephropathy to chronic kidney failure.

In addition, there are many cases of chronic renal failure due to renal sclerosis caused by high blood pressure, lupus nephritis caused by systemic lupus erythematosus, and polycystic kidney disease.

Renal failure mainly includes primary glomerulonephritis, chronic pyelonephritis, hypertensive renal arteriole sclerosis, diabetic nephropathy, secondary glomerulonephritis, tubulointerstitial lesions, hereditary kidney diseases, long-term use of antipyretic analgesics and exposure to heavy metals. In traditional Chinese medicine, there are also some drug ingredients that can cause damage to the kidneys, so patients with kidney failure are advised to use them with caution. Kidney failure is currently mainly based on hemodialysis or renal replacement**.

Kidney failure requires an immunological regimen and I need to know about the patient's condition. I'm a nephrologist and I know the patient's condition.

Chronic renal failure is a relatively common disease in our daily life, and it has a great impact on people. So, what causes chronic kidney failure? Let me tell you the causes of chronic kidney failure!

What causes chronic kidney failure

1. Kidney disease: it is the most direct and main cause of uremia. All kinds of kidney diseases, if the disease is not effectively controlled, the final outcome will be uremia, such as glomerulonephritis, nephrotic syndrome, kidney stones, urinary tract obstruction, renal vascular diseases, hereditary kidney disease, kidney tumors, etc.

2. Other concomitant diseases: such as diabetes, hypertension, lupus erythematosus, Henoch-Schonlein purpura, etc., renal damage can occur with the prolongation of the course of the disease, and it can further deteriorate into uremia. Among them, diabetic nephropathy and hypertensive nephropathy are the most common and serious types of secondary kidney disease, which are the main causes of chronic renal failure caused by such factors.

3. Uremia caused by drug damage to the kidneys: antibiotics, some anti-inflammatory drugs, medical contrast agents, anti-tumor drugs and some traditional Chinese medicines are all nephrotoxic drugs, which are easy to cause damage to the kidneys and thus lead to the formation of uremia.

Prevention of chronic renal failure

1) Actively prevent the occurrence of chronic renal failure for various acute and chronic glomerulonephritis, lupus nephritis, purpura nephritis or diseases that may affect the kidneys (such as hypertension and diabetes).

2) Avoiding or eliminating certain risk factors, the application of drugs that are toxic to the kidneys, serious infections, dehydration, urinary tract obstruction (such as stones, prostatic hypertrophy), trauma and other factors can often aggravate the original kidney disease, deteriorate kidney function, and promote the occurrence of renal failure. In fact, regular, high-quality follow-up can reduce or avoid the occurrence of these risk factors, or detect and correct them early.

3) A reasonable diet with a low-protein, low-phosphorus and low-fat diet has been laboratory and clinically proven to protect renal function in chronic kidney disease. It is emphasized that protein intake should be limited in order to prevent the development of chronic renal failure.

4) The application of angiotensin-converting enzyme inhibitors can not only control systemic hypertension, but also correct glomerular hyperperfusion and hyperfiltration, and delay the occurrence of renal failure. The commonly used drugs in clinical practice are captopril, lodine and ripressin.

Many kidney diseases are late-stage chronic renal failure. In our country, the most common ** is primary glomerulonephritis. The most common primary glomerulonephritis is IgA nephropathy and other membranous nephropathy and membranous proliferative nephritis. , and focal segmental sclerosis can lead to chronic renal failure. In recent years, with the improvement of living standards, our primary diseases are also changing, the incidence of diabetes is gradually increasing, and the incidence of end-stage renal failure caused by diabetic nephropathy is also gradually increasing. <>

There are other secondary glomerulonephritis, such as autoimmune diseases, lupus nephritis, vasculitis, Henoch-Schonlein purpura nephritis, multiple myeloma, etc., which can cause renal failure. Chronic interstitial nephritis can also lead to kidney failure, such as drug-induced kidney failure and chronic interstitial nephritis caused by certain allergic factors. There are other genetic conditions, such as Alport syndrome, polycystic kidney disease, etc., that can lead to kidney failure.

From the beginning of the primary disease to renal insufficiency, the interval can range from several years to more than ten years. Chronic renal failure is a severe stage of renal insufficiency. <>

The first of the first is primary and secondary glomerulonephritis, followed by congenital malformations of the urinary system (such as renal dysplasia, congenital polycystic kidney, vesicoureteral reflux, etc.), hereditary diseases (such as hereditary nephritis, renal medullary cystic disease, Fanconi syndrome, etc.), systemic diseases are more common in renal arterioles, hypertension, connective tissue diseases, etc. <>

In recent years, there has been a change in the primary disease of CRF. CRF caused by renal interstitial tubular injury is gradually attracting attention. Diabetic nephropathy, autoimmune and connective tissue disease kidney damage, and CRF due to kidney damage are also on the rise.

Chronic renal failure affects various systems and organs and can cause a variety of clinical manifestations. However, there may be no symptoms or only a few symptoms before 80% of nephrons are lost, or when GFP drops to 25ml min. Biochemical changes.

In chronic progressive diseases such as polycystic kidney disease, symptoms may not occur even if the GFR is less than 10 ml min. This is due to the great adaptability of the remaining nephrons.

Chronic renal failure is the final development of kidney disease, and the common causes of chronic renal failure are primary and secondary glomerulonephritis, such as acute glomerulonephritis, chronic glomerulonephritis, nephrotic syndrome, systemic lupus erythematosus renal damage, and rheumatoid arthritis renal damage.

In the era of economic underdevelopment, chronic glomerulonephritis is more common, and renal insufficiency caused by infectious diseases is prolonged, causing chronic renal failure;

With the development of the economy, common metabolic diseases cause renal insufficiency and cause chronic renal failure. Among them, diabetic nephropathy is the most common, causing chronic renal insufficiency, accounting for more than 40%.

Kidney failure due to type 2 diabetes is also common; Chronic renal failure caused by hypertension and kidney damage is also more common, and is currently considered to be the second; Some relatively uncommon diseases, such as immune diseases, uremia nephropathy, lupus nephritis, etc., can also develop into renal failure.

It is a chronic disease in which the internal tissues of the kidneys are damaged and cannot be metabolized and waste products are excreted, which is caused by regular drinking.

Chronic renal failure refers to the decline of kidney function caused by a variety of kidney diseases. In general, chronic renal failure is caused by chronic nephritis.

Kidney failure is when kidney function decreases over time. Maybe it's because I don't pay attention to sleep too much.

There are many causes of chronic kidney failure. We know that chronic renal failure is actually caused by a variety of causes in life. Chronic kidney failure can cause substantial damage to our kidneys, and it is important to be very careful and prompt** when such symptoms occur, both in the early and late stages.

But when we prepare, we also need to understand, what is chronic kidney failure? What are the causes of chronic kidney failure? Let's take a look.

What are the causes of chronic kidney failure? Know, Prevent and Prevent.

The primary cause of chronic renal failure is the long-standing phenomenon of chronic kidney disease, coupled with the gradual deterioration of symptoms leading to kidney failure, the main cause of which is the presence of various primary glomerulonephritis. Their streptococcal infections progressed from chronic kidney stones to more severe nephritis, membranous proliferative nephritis, acute progressive nephritis, etc. Another reason is that there are other systemic diseases that can directly lead to kidney disease, which we call chronic renal failure, such as diabetic nephropathy, gout and chronic hypertension.

The main reason for the occurrence of chronic renal failure is due to primary glomerulonephritis, chronic pyelonephritis, hypertension and renal arteriolar sclerosis or because of improper use of antipyretic and analgesic oral drugs, excessive exposure to heavy metals and chemical industrial materials, inhalation into the body, resulting in kidney lesions and body failure.

What are the causes of chronic kidney failure? Understand that there are many reasons for early prevention and chronic renal failure because the kidneys are damaged, mainly because the glomeruli are damaged in a large area, and due to the severe pathological changes in the renal interstitial tubules, which leads to kidney failure, which inhibits the normal work of the renal blood vessels, resulting in abnormalities and protrusions, so kidney failure must go to the hospital to find out the specific cause, carry out**or drugs**, and do not blindly solve it by yourself. The cause of renal degeneration in chronic renal failure may also be caused by some irreversible factors, such as kidney damage caused by infection or drugs, poisoning caused by slow metabolism, dehydration, frequent hypotension, etc.

There are many causes of chronic kidney failure, and most of these diseases are caused by a variety of chronic kidney diseases related to the body. It is still relatively common now, in fact, the disease of young people may be related to IgA nephropathy, which is mainly manifested by upper respiratory tract infection, renal hematuria, proteinuria, repeated and unhealed, and may eventually lead to chronic renal failure. The most common types of kidney damage in middle-aged and elderly people are hypertensive kidney damage and diabetic kidney damage, as well as hereditary diseases, such as polycystic kidney disease, which can also cause chronic kidney failure.

The most common ones are cerebral thrombosis, coronary heart disease, which can be caused by it, and it should also be taken seriously.

There are many reasons for the formation of chronic renal failure, and one of the main reasons is the occurrence of glomerulonephritis caused by various pathophysiological changes caused by immune complexes. For kidney failure, the first thing is to clarify what causes kidney failure, and at the same time, it is necessary to choose different programs according to different periods of kidney function. Generally speaking, in the early stage of kidney failure, a combination of traditional Chinese and Western medicine can be used**, and it is recommended to treat the kidney with traditional Chinese and Western medicine to solve the disadvantages of treating the kidney and injuring the kidney, which can remove the immune complex that causes glomerular basement membrane damage, and repair the pathological damage of the kidney while reducing the symptomatic index.

And it can be taken for a long time.

1. Chronic glomerulonephritis: such as IgA nephritis, membrane proliferative glomerulonephritis; Focal segmental sclerosing glomerulonephritis and mesangial proliferative glomerulonephritis, etc.

2. Kidney damage caused by metabolic abnormalities, such as diabetic nephropathy, gouty nephropathy and amyloidosis nephropathy;

3. Vascular nephropathy, such as hypertension, renovascular hypertension, renal arteriolar sclerosis, etc.;

4. Hereditary kidney diseases, such as polycystic kidney disease, Alport syndrome, etc.;

5. Infectious nephropathy, such as chronic pyelonephritis, renal tuberculosis, etc.;

6. Systemic diseases, such as lupus nephropathy, vasculitis, kidney damage, multiple myeloma, etc.;

7. Toxic nephropathy, such as analgesic nephropathy, heavy metal toxic nephropathy, etc.;

8. Obstructive nephropathy, such as ureteral obstruction; Reflux nephropathy, urinary tract stones, etc.

Chronic renal failure is a clinical symptom of various chronic kidney diseases, such as progressive renal damage, which causes waste retention, water and electrolyte metabolism disorders, acid-base imbalance, etc., so all kinds of diseases that can cause kidney damage, if they continue to develop progressively, can cause uremia. These diseases can be various diseases that are primary in the kidneys or can be secondary to other systemic diseases. Among them, the most common diseases are various types of chronic glomerulonephritis, followed by pyelonephritis and interstitial nephropathy.

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The common causes of chronic renal failure are:

1. Chronic glomerulonephritis:

2. Kidney damage caused by metabolic abnormalities: such as diabetic nephropathy, gouty nephropathy, etc.;

3. Vascular nephropathy: such as hypertension, renal arteriolar sclerosis, etc.;

4. Hereditary kidney diseases, such as polycystic kidney disease, Alport syndrome, etc.;

5. Infectious nephropathy, such as chronic pyelonephritis, renal tuberculosis, etc.;

The above content is for reference!