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Wet granulation, spray granulation,
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The material is plasticized into round bars by an extruder and extruded, and the round bars are air-cooled or water-cooled, and then cut into cylindrical particles by a pelletizer: cold cutting method. There are several commonly used methods of dry hot cutting:
One; 3.Cold cutting of pulling tabs: the materials through the kneading machine or internal mixer are molded into pieces by the open mixer and cooled and then pelletized; 2.
Extrusion is cold.
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The purpose of granulating the curry:
1. Improve liquidity. Generally, the particle size is larger than that of powder, and the number of particles that can be contacted around each particle is small, so the adhesion and agglutination are greatly weakened, so as to greatly improve the fluidity of the material.
2. Prevent the segregation of each component. When there are differences in the particle size and density of each component of the mixture, segregation is easy to occur, and segregation can be effectively prevented by mixing and dismantling the poor grains or mixing after granulation.
3. Prevent dust from flying and adhesion on the wall. The dust flying and adhesion of the powder are serious, which can prevent environmental pollution and loss of raw materials after granulation, which is conducive to the management of GMP.
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Answer]: The granulation method and the purpose of granulation are as follows.
1) Granulation method. Wet granulation: beautiful appearance, good fluidity, strong wear resistance, good compression molding.
Such as high-speed stirring granulation, fluidized bed granulation, spray granulation, rotary granulation, extrusion and punching out round granulation, extrusion granulation, and granulation of spheroids in liquid phase. Dry granulation: It is often used for the granulation of heat-sensitive materials, drugs that are easy to decompose in contact with water and drugs that are easy to compress molding, with a simple, time-saving and labor-saving method.
Such as rolling method, blockbuster method. Other methods of granulation.
2) The purpose of granulation. Improve liquidity. Prevents segregation of components.
Prevents dust from flying and sticking to the wall. Adjust bulk density to improve solubility. Improves uniform pressure transfer in tablet production.
It is easy to take, easy to carry, and increases the value of the product.
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Wet granulation: a method of preparing granules by adding a liquid binder to the pharmaceutical powder, and coalescing the powder together by the bridging or bonding action of the binder. The product has beautiful appearance, good fluidity, strong wear resistance and good compression formability.
Raw and auxiliary materials: one crushing, one mixing, one soft material, one granulation, one drying, one whole grain, one tablet.
The dry granulation method is a method of mixing the powder of drugs and excipients evenly, compressing them into large flakes or reed plates, and then crushing them into particles of the required size. It is used for heat-sensitive materials and drugs that are easy to decompose in water, with simple methods and labor-saving and time-saving.
Drugs + excipients Crushing, sifting, mixing, briquetting, crushing, whole granules, mixing, tableting.
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The following statement about granulation is correct ().
a.Granulation is the processing of powder into a certain shape and the size of the granules.
b.During the granulation process, it is often necessary to add fillers to increase the weight and volume of the preparation.
c.Granulation operation technologies include dry granulation and wet granulation technologies.
d.Wet granulation technology refers to the method of adding wetting agent or liquid binder to the material for granulation.
e.Dry granulation technology refers to the method of mixing materials evenly, compressing them into large sheets or plates, and then crushing them into particles of the desired size. According to the different equipment used in granulation, it can be divided into heavy pressure granulation technology and rolling granulation technology.
Correct answer: ABCDE
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Granulation refers to compressing or extruding the material into a granular material with a certain shape and size through a certain process.
Granulation is usually used to prepare solid particles, powders, particle mixtures, etc., and is widely used in chemical, pharmaceutical, food, agriculture and other fields. A process in which finer particles are agglomerated into coarse powder agglomerates to improve powder flowability.
Granulation is the operation of processing materials in the state of powder, molten liquid, aqueous solution and other states into granules of a certain shape and size. Almost all solid dosage forms are prepared without the granulation process. The pellets made may be the final product, such as granules; Also spikes may be intermediate products, such as tablets.
Pharmaceutical granulation is to mix raw materials (extract for traditional Chinese medicine) with a certain proportion of excipients, and use water or ethanol as a wetting agent to make particles of the required size. Some dosage forms such as tablets, capsules, etc., granules are an intermediate, while some dosage forms such as granules, granules are a final product, so the granulation process or preparation process is a very important link in the preparation production process.
1. Granulator.
Granulator is a kind of mechanical equipment specially used for granulation, mainly including tablet presses, extruders, pelletizing machines, etc. They go through a series of processes to compress or extrude the material into granular materials of a certain shape and size.
2. Granularity. Particle size refers to the size and distribution of particles. In the granulation process, it is very important to control the particle size, because different particle sizes and distributions will affect the properties of the material and the application effect.
3. Compression ratio.
The compression ratio refers to the proportion of the volume reduction of the material after a certain compression force in the pellet mill. The larger the compression ratio, the higher the density of the material and the better the granulation effect.
4. Extrusion rate.
Extrusion rate refers to the rate at which material passes through the extrusion head in an extruder. The higher the extrusion rate, the better the fluidity of the material and the better the granulation effect.
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