What are the main components of the base of the babu agent? 30

Babu agent technology.

Transdermal drug delivery system is the current frontier in the field of pharmacy, and the drug has many advantages in absorption. Traditional plasters (ointments, black plasters) are based on fat-soluble materials, which have serious defects in application, small drug load, poor transdermal performance, allergies, rashes, sticky hair, contaminated clothes, etc. In the late seventies, Japan developed water-soluble matrix patches to open up the Western market, and this type of patch was included"Japanese pharmacy prescription"Named"Babu agent".

There are a large number of such products in Japan and the West.

Babu agent (water-based plaster) is a plaster made of water-soluble polymer compounds or hydrophilic substances as a matrix, and traditional Chinese medicine extracts or powders are refined, which has the advantages of good compatibility, affinity, air permeability, sweat resistance, good repetition and removal, large drug loading, high bioavailability, no contamination of clothing, and not easy to allergies. Compared with rubber plaster, black plaster can make the stratum corneum cells hydrate and swell, which is conducive to the transdermal absorption of drugs, and the curative effect has been greatly improved. Water-soluble substrates can be used in a wide range of applications, including water-soluble and fat-soluble drugs, and are an ideal replacement product to replace existing patches.

After years of research, a lot of work has been done in the formulation and preparation process of the babu agent, so that the viscosity, ductility, moisturizing and strength of the babu agent meet the requirements of use.

This product is a corporate secret. No comment.

Preparation of babu paste: substrate gelatin 3 g, nitrogen ketone g, gum arabic 4 g, polyethylene glycol 4 005 g, sodium polyacrylate 4 g, glycerin 4 g, zinc oxide g. Preparation process 1 Alcohol extraction prescription medicinal materials were crushed into coarse particles (10 mesh) 100 g, 300 ml of 95% ethanol was added, and extracted 3 times, the first time was 2 h, the second time was 1 h, and the third time was 40 min

There are sodium polyacrylate, sodium hydroxymethylcellulose, sorbitol, polyfisquitous vinyl alcohol, gelatin, and glycerinetc(commonly used matrices).

The 2010 edition of the Pharmacopoeia has changed the babu plaster to a gel plaster. Babu concept: Babu is a topical plaster that has a long history of application in Japan.

It is a plaster made of medicinal extracts, medicinal materials or chemical drugs mixed with a suitable hydrophilic matrix and coated on the backing material, which is composed of a backing (commonly used non-woven fabric, elastic cloth), paste, and anti-mucous film (isolation film on the surface of the paste).