What are the dangers of insulin resistance to the body?

Insulin resistance can cause the following harms.

a. High blood sugar.

b. Hyperinsulinemia, hypertension, hyperlipidemia, macrovascular disease.

Cardiovascular: ischemic heart disease (myocardial infarction).

Cerebrovascular: stroke.

Peripheral blood vessels: foot gangrene.

Eyes: Retinopathy (blindness).

Kidneys: proteinuria.

Nerves: numbness of the hands and feet.

c. Premature failure of pancreatic islet cell function.

Experts warn: Diabetes is not terrible, what is terrible is complications, and what is even more terrible is not finding the "culprit" of complications - insulin resistance. Because insulin resistance can not only trigger the occurrence of hyperglycemia, but also cause high blood insulin levels (i.e., hyperinsulinemia), resulting in hypertension and dyslipidemia, both of which will cause serious damage to the large blood vessels throughout the body, insulin resistance is the root cause of the occurrence and aggravation of macrovascular disease.

Therefore, the key to preventing and blocking macrovascular disease is to effectively relieve "insulin resistance".

Insulin Resistance Hazards:

1. It can lead to hyperinsulinemia.

When there is an abnormality of insulin resistance, the blood sugar in the body will be out of control, and hyperglycemia will occur, which will also lead to a continuous increase in the level of insulin in the blood, resulting in hyperinsulinemia, which will increase blood pressure and blood lipids at the same time.

2. It can lead to serious damage to blood vessels.

Under the influence of insulin resistance, blood sugar, blood pressure, and blood lipids will rise abnormally, resulting in excessive pressure on blood vessels, causing serious damage to blood vessels and causing some vascular lesions.

3. It can lead to blindness.

Many people may not know the relationship between vision loss and insulin resistance, because severe insulin resistance can lead to damage to blood vessels throughout the body, which affects the surrounding nerves, causing some patients to have vision loss and even blindness.

4. Numbness in hands and feet.

Numbness in the hands and feet is a major symptom of elevated blood lipids, and most patients did not think that it was caused by elevated blood lipids before the numbness of the hands and feet was clarified, and the awareness and understanding of this aspect still need to be strengthened.

Enhance the phagocytosis of peritoneal macrophages in burned mice, and increase the level of serum hemolysin antibodies.

The best choice of streptozotocin-induced animal diabetes model has a selective destruction effect on the islet cells of certain species of animals, and can induce diabetes in many animals, and animal models are generally made from rats and mice.

A control experiment was designed to inject STZ and the same amount of normal saline, and the change of blood glucose content was measured, and if the blood glucose concentration of STZ and normal saline injection was the same, the pancreatic B cells were not destroyed.

Rabbits containing glucose in their urine may only be the residue of eating too much sugar at one time, which exceeds the reabsorption capacity of the kidneys; It may also be a lesion of renal reabsorption capacity and is generally not used as an indicator of observation.

The blood insulin content of the two groups of rabbits was measured, and if the insulin content of the rabbits injected with STZ was significantly lower than that of the same amount of normal saline, it indicated that the pancreatic B cells were destroyed.

Since 1999, the applicant has been engaged in experimental and clinical research on diabetes mellitus with the funding of Shandong Provincial Department of Health.

So far, three animal models of diabetes mellitus and pancreatic islet resistance have been replicated (type 1 diabetic rats with streptozotocin replicated, insulin-resistant rats fed with high fructose, and insulin resistance models replicated with streptozotocin on the day of birth), and it has been found that the peripheral blood leukocytes of STZ diabetic rats do not have an inos-mRNA table.

Causes of insulin resistance:

1.Overweight and obese people: excessive visceral fat and insulin resistance also have a certain relationship, normal men's fat content is not more than 20, and women's fat content generally does not produce more than 30, if we have too much fat in the body, it will directly lead to excessive accumulation of visceral fat, and fat will secrete adipokines to play a role in resisting insulin, so that the role of insulin continues to decline.

Therefore, for overweight and obese people, it is necessary to pay attention to internal control of their weight and reduce the fat content of internal organs.

2.Hyperthyroidism: In patients with hyperthyroidism, their thyroid hormones may be excessively secreted, which may directly lead to resistance to insulin levels and a decrease in the role of pancreatic islets.

3.Growth hormone tumors: For example, patients with gigantism and acromegaly, who have higher levels of growth hormone, can also develop insulin resistance, which reduces insulin secretion and is more likely to develop diabetes.

It's because we have antibodies in our body. Insulin, on the other hand, is a poison. The red blood cells in our body resist this poison.

It may be due to genetic factors, environmental factors, bad lifestyle habits, frequent eating of high-fat foods, long-term smoking and drinking, lack of exercise, etc.

Because there is a problem in the body's liver, glucose cannot form glycogen for storage, so the problem of insulin resistance occurs.

It may be because there are too many antibiotics in the body. It usually happens to people who take medicine regularly. Because they produce antibodies.

Insulin is a hypoglycemic hormone secreted by pancreatic islet cells, and insulin is the only hypoglycemic hormone in the body. The role of insulin in the human body is mainly the following two things:

1. Regulate blood sugar, when the blood sugar concentration increases, it will promote insulin secretion, insulin can promote the uptake and utilization of glucose, promote the conversion of glucose into glycogen, thereby reducing blood sugar. When the blood glucose concentration decreases, it will inhibit the secretion of insulin, inhibit the uptake and utilization of glucose, and convert the stored glycogen into glucose to maintain the blood glucose concentration, so blood sugar is a dynamic balance between various glycemic hormones and insulin. Diabetes occurs when insulin is insufficient.

2. Insulin has a synthetic-promoting effect, which can promote the synthesis of proteins and fats, and inhibit the decomposition of proteins and fats. Therefore, insulin is a nootropic hormone that can promote the synthesis of protein, fat and glycogen at the same time, and exert a powerful hypoglycemic effect.

There are many causes of insulin resistance, the main ones are the following:

1. Overweight and obese people: insulin resistance is related to excessive visceral fat, the fat content of normal men does not exceed 20%, and the fat content of women does not exceed 30%, if the fat content is too much, resulting in excessive accumulation of visceral fat, fat will secrete adipokines, adipokines play a role in insulin resistance, so that the role of insulin decreases, so overweight and obese people should control their weight and reduce the content of visceral fat, which can improve insulin resistance and strengthen insulin sensitivity;

2. Cushing syndrome: Cushing syndrome is caused by many reasons, glucocorticoids accumulate too much in the body, glucocorticoids resist insulin, so patients with Cushing syndrome will have obvious insulin resistance, resulting in a decrease in the effect of insulin, patients are prone to abnormal blood sugar metabolism, secondary diabetes;

3. Hyperthyroidism: Patients with hyperthyroidism secrete excessive thyroid hormone, resulting in insulin resistance and decreased insulin effect;

4. Growth hormone tumor: For example, patients with gigantism and acromegaly, the level of growth hormone in the body is too high, and insulin resistance occurs, resulting in a decrease in insulin effect, and patients are prone to diabetes.

Harms: Sudden headache, dizziness, vomiting, clumsiness, trembling, blurred vision, rapid heartbeat, slurred speech, sweating, difficulty walking, confusion, so that it is often mistaken for drunkenness.

In severe cases, convulsions or coma may occur, and if not treated immediately, death may occur. People with diabetes don't eat enough food to balance their insulin doses, which means that insulin shock can flare up if they miss or miss a meal, or if they vomit, drink alcohol, get too active, and don't eat enough food.