Precautions for cyclosporine capsules, contraindications for cyclosporine capsules

1. Patients taking cyclosporine should regularly monitor the blood drug trough concentration (that is, the blood concentration before each dose). Your doctor will adjust the dose of the drug according to your blood level so that your blood level is as effective and safe as possible. Because if the blood concentration of cyclosporine does not reach the ** concentration, it may lead to unsatisfactory or even ineffective efficacy, but if the blood concentration exceeds the upper limit of the ** concentration, it may increase the risk of drug-related adverse reactions.

2. To monitor the blood concentration, blood must be drawn before taking cyclosporine in the morning, and cyclosporine should be taken after blood drawing, otherwise it will seriously affect the test results and affect the adjustment of drug dose.

3. It is generally recommended to take the drug more than 1 hour before or more than 2 hours after a meal to avoid the influence of food on the absorption of cyclosporine. And try to keep the 2 doses a day apart about 12 hours (e.g., cyclosporine once at 7 a.m. and a second cyclosporine at around 7 p.m.).

4. Patients should not switch to other brands of drugs when the application of one brand of cyclosporine** is stable. If a different brand of drug must be changed, the trough blood level needs to be monitored until the target concentration is stable. Because there are considerable differences between different brands of cyclosporine in terms of drug onset and metabolism, this is an uncommon phenomenon in the application of other drugs.

5. Note that some drugs or foods may affect the blood concentration of cyclosporine.

1.Drugs that can increase the concentration of cyclosporine: diltiazem, pentaesters tablets (the main ingredient is schisandra a), nicardipine, verapamil, fluconazole, itraconazole, ketoconazole, clarithromycin, erythromycin, amiodarone, etc.

2.Foods that can increase cyclosporine concentrations: grapefruit juice; Drugs that can reduce the concentration of cyclosporine: rifampicin, carbamazepine, phenobarbital, phenytoin, octreotide, etc.

1. It can be taken before or after meals, but the method of taking it should be the same each time, always taking it with food or always on an empty stomach.

2. The total daily dosage should be divided into two doses (morning and evening), and the medicine should be taken at a fixed time every day.

3. Before taking the medicine, you can drink a sip of water to moisten the throat to avoid the medicine sticking to the wall of the mouth or esophagus. Sitting or standing, rubber-shaped with 200ml of warm water.

4. Swallow the capsule whole, do not open or chew the capsule. If you have trouble swallowing, talk to your doctor.

5. Do not lie down immediately after taking the medicine, and only lie down after 20-30 minutes of activity.

6. If you are taking sirolimus, please take this product 4 hours after taking it. **Blood levels should be monitored during this period.

1. In general, the drug is taken with plain water, but sometimes the doctor may recommend taking it with milk, because cyclosporine is fat-soluble, and taking it with milk can promote its absorption. 2. The time of taking should be fixed, because cyclosporine is a fat-soluble drug, and the oral nucleus is slow and easy to be affected by some foods, so the time between taking medicine and diet should be fixed, so as not to affect the concentration of drugs due to changes in meal time.

General contraindications: This product is contraindicated in patients who have an allergic reaction to cyclosporine or any of the components of the preparation. Patients with rheumatoid arthritis:

Patients with rheumatoid arthritis with abnormal renal function, uncontrolled hypertension or malignant tumors should not use this product. Psoriasis patients: Psoriasis patients using this product** should not receive radioactive ** such as (PUVA or UVB), methotrexate or other immunosuppressants, coal tar or radiation** at the same time.

Psoriasis patients with abnormal kidney function, uncontrolled hypertension or malignant tumors should not use this product.

1. This product has been proven by animal experiments to increase the risk of carcinogenicity. Although there have been reports of concurrent lymphoma and ** malignant tumors in humans, there is no evidence of mutagenicity. 2. This product can pass through the placenta.

The application of 2 5 times the dose of human can be toxic to rats, rabbit embryos and fetuses, but according to the conventional dose of human medicine, no lethal or teratogenic occurrence of embryos of such animals has been seen. 3. Use with caution in the following conditions: liver insufficiency, hyperkalemia, infection, intestinal malabsorption, renal insufficiency, intolerance to taking this product, etc.

4. Interference with diagnosis: (1) In the first few days of using this product, blood urea nitrogen and creatinine can be increased, which does not necessarily indicate that it is a rejection of kidney transplantation; (2) Serum alanine aminotransferase [ALT], aspartate aminotransferase [AST], amylase, alkaline phosphatase, and blood bilirubin can be increased due to the toxicity of this product to the liver; (3) Serum magnesium concentration can be reduced, which is related to the nephrotoxicity of this product; (4) Serum potassium and serum uric acid may be elevated. 5. If this product has caused renal insufficiency or has a continuous negative nitrogen balance, the dose should be reduced or stopped immediately.

6. In case of infection, antibiotics should be used immediately**, and the dose of this product should also be reduced or stopped. 7. If the transplant is rejected, the dose of this product should be increased. 8. In the prevention of organ or tissue transplant rejection and autoimmune diseases, the dose of this product is often not completely unified due to the disease, individual differences, and different blood concentrations after using this product.

9. Remove from the foil blister only before taking it.

1. The product is forbidden when it is infected by viruses: such as chickenpox, shingles, etc.

2. Those who are allergic to cyclosporine are prohibited.

3. Patients with severe liver and kidney damage, uncontrolled hypertension, infection and malignant tumors should not use or use with caution.