Lipid lowering drugs that can improve metabolic hyperlipidemia

Since the onset of hyperlipidemia is a chronic process, mild hyperlipidemia usually does not have any uncomfortable sensations, but the absence of symptoms does not mean that the blood lipids are not high, and it is important to check the blood lipids regularly. When hyperlipidemia is severe, symptoms such as dizziness, headache, chest tightness, shortness of breath, palpitation, chest pain, fatigue, crooked corners of the mouth, inability to speak, and numbness of limbs will occur, which will eventually lead to serious diseases such as coronary heart disease and stroke, and corresponding manifestations will appear. In general, hyperlipidemia refers to a condition in which blood lipids such as cholesterol, triglycerides, phospholipids, and unlipidated fatty acids in the plasma are elevated.

High blood lipidemia is caused by eating too many fatty and cholesterol-containing foods, and is also related to genetic factors.

PS: In addition to medication, I should also pay attention to some dietary habits and work pressure.

Eat less animal liver, fried food, eat more vegetables and fruits, and eat some wingfruit oil to adjust well.

Improve sleep quality and exercise properly! It is good for regulating blood lipids.

Eat less salty foods. Because eating high salt content is easy to high high blood pressure is mainly improved by adjusting the dietary structure, try not to eat or eat less foods with high cholesterol, such as animal offal, brain, bone marrow, caviar, shellfish, squid, eel, etc. It is necessary to eat high-fiber vegetables, melons and fruits, which contain a large amount of plant sterols, which can inhibit cholesterol absorption and play an anti-arteriosclerosis effect.

Moderate or small amounts of alcohol can also lower cholesterol, with 45 ml of liquor or 90 ml of dry red or 188 ml of beer per day. For patients with pre-existing hyperlipidemia, on the one hand, it is necessary to control the diet, on the other hand, it is necessary to carry out moderate exercises such as jogging, through exercise, the lipase activity in the fat increases, and the blood lipids decrease accordingly The drug is really hard to say, it varies from person to person, and everyone's physical condition is different.

If you don't do it, you should take as little medicine as possible, pay attention to dietary regulation, exercise moderately, reduce greasy, high-fat foods, and eat some wingfruit oil.

Answer]: eProbucol lowers blood cholesterol and LDL by reducing cholesterol synthesis and promoting cholesterol decomposition; By changing the nature and function of the high-density lipid egg (HDL) egg tannel subtype, affecting the functions of soft phospholipid cholesterol acyltransferase and cholesterol lipid transfer protein and apolipoprotein E, and normalizing the ratio of lipidized cholesterol to total cholesterol, the reverse transport of blood HDL cholesterol was strengthened. Inhibition of the adhesion of mono-sin nucleocytes to endothelial cells by inhibiting the expression of intercellular adhesion factor-1 and p-selectin. Therefore, this product can prevent atherosclerosis and the cardiovascular and cerebrovascular diseases caused by it.

There are many types of hypolipidemic drugs in pharmacies and drug depots, so what are the common hypolipidemic drugs? We should first recognize the types of lipid-lowering drugs.

Common ones on the market are fibrates, statins, bile acid isolates, and niacin. In terms of pharmacodynamic properties, fibrates have a significant reduction effect on triacylglycerol, such as fenofibrate (lipid), gemfibrozil (nuoheng) and benzofibrate (bicidecibrate); Statins have a significant lowering effect on cholesterol and low-density lipoprotein, such as lovastatin (melidine-lowering), simvastatin (lipid-lowering), pravastatin (pragu), fullvastatin (leoxyco) and atorvastatin (lipitor), etc.; Bile acid isolates and niacin drugs are now less commonly used. In addition, there are also traditional Chinese medicine preparations, such as red arm preparations (lipito, Xuezhikang) and so on.

At present, statins are the most widely used and the most certain. Hypolipidemic drugs are currently one of the main means of hyperlipidemia, and their main mechanisms of action are as follows:

1. Prevent the absorption of bile acid and cholesterol from the intestine and promote the excretion of bile acid and cholesterol with feces;

2. Inhibit the synthesis of cholesterol in the body and promote the conversion of cholesterol;

3. Promote the expression of low-density lipoprotein receptor on the cell membrane and accelerate the decomposition of lipoprotein;

4. Activate lipoprotein metabolizing enzymes and promote the hydrolysis of triacylglycerol;

5. Prevent the synthesis of other lipids in the body, or promote the metabolism of other lipids. A certain hypolipidemic drug may have one of the above mechanisms, or it may have multiple lipid-lowering mechanisms. However, different types of drugs have different curative effects on different hyperlipidemic patients, and some patients do not understand their own conditions and blindly take hypolipidemic drugs, which not only has no efficacy but produces ***.

Therefore, the choice of hypolipidemic drugs is very important, and the choice should be made carefully and according to the doctor's instructions.

Drugs commonly used to lower blood lipids include statins, fibrates, niacin, resins and other drugs. The most commonly used are statins, the main effect of statins is to reduce serum total cholesterol and LDL, but also to a certain extent to reduce triglycerides and very low-density lipoprotein, and slightly increase HDL levels. The indications are hypercholesterolemia and mixed hyperlipidemia dominated by elevated cholesterol, and the commonly used ones are simvastatin, pravastatin, fluvastatin, atorvastatin, rosuvastatin, etc.

For patients with predominantly elevated triglyceridemia, fibrates may be given. Commonly used are fenofibrate, bezafibrate, etc. Niacin drugs, niacin belongs to B vitamins, which can reduce serum total cholesterol and LDL cholesterol, and can also reduce LDL and apolipoprotein A.