What is a third generation test tube? Under what circumstances can I do three generations of test tu

The third generation of IVF, also known as preimplantation genetic diagnosis, refers to the fact that before IVF embryo transfer, we take out one or several cells of the embryo for genetic material examination to diagnose whether the embryo is abnormal, and then we screen out healthy embryos for transfer and implant them in our uterine cavity. It's not that our second generation is better than the first generation, and the third generation is better than the second generation, but different types of patients need to adopt different IVF methods. The third generation of IVF is suitable for patients with chromosomal abnormalities or genetic diseases related to genes, and he can delete the inherited genes through the third generation of IVF, and enable the patient to give birth to a healthy child.

The third generation of IVF, also known as preimplantation genetic diagnosis (PGD), refers to the method of taking the genetic material of the embryo for analysis before the embryo transfer of IVF-ET, diagnosing whether there is any abnormality, screening healthy embryo transfer, and preventing the transmission of genetic diseases.

What is the third generation of IVF.

The third generation of IVF, also known as preimplantation genetic diagnosis, refers to the genetic material of the embryo before the embryo is transferred, the genetic material of the embryo is analyzed, whether there is an abnormality, and then the healthy embryo is screened for transfer, and its main purpose is to prevent the transmission of genetic diseases. It is reported that a hospital in China has successfully assisted the birth of a singleton baby with thalassemia combined with the leukocyte antigen system (HLA) through the third-generation test-tube baby technology, which is used for the severe thalassemia of his sibling sister.

The three cores of the third-generation IVF PGD PGS technology:

1. PGS blastocyst preimplantation genetic screening technology.

PGS is preimplantation genetic screening, before the embryo is implanted, PGS is used to detect the number of chromosomes and structural abnormalities in early embryos, mainly by detecting the structure and number of 23 pairs of chromosomes of the embryo, and analyzing whether the embryo has abnormal genetic material through comparison.

The PGS blastocyst preimplantation genetic screening of the third generation of IVF is helpful for IVF**, especially for advanced maternal age and multiple natural conceptions or miscarriages after IVF and infertility patients who want to have children. However, only observing the external morphological characteristics can not accurately determine whether the chromosomes are abnormal, if preimplantation genetic screening PGS is carried out during the development process, it can accurately screen out whether the chromosomes are normal, which can effectively improve the probability of successful conception and delivery of a healthy baby.

Second, the third generation of IVF NGS gene sequencing technology is a new generation of PGS gene screening technology upgrade technology, on the whole, NGS technology has the advantages of large throughput, short time, high accuracy and rich information, experts can accurately locate genes in a short time, for clinical diagnosis and to ensure the success rate of IVF play a role in multiplying the result with half the effort.

NGS gene sequencing technology takes 7 to 14 days to issue an examination report, so the premise of choosing this technology is to choose frozen embryo transfer (that is, the cultivated blastocyst is frozen and the blastocyst transfer is performed after the NGS test results are available); The next-generation sequencing technology NGS will bring patients a more accurate test result, and the success rate of IVF will be greatly improved.

3. PGD of IVF is a preimplantation genetic diagnosis of blastocysts.

PGD genetic diagnosis can determine whether an embryo carries a genetic mutation that can lead to a specific disease, which is a segment of DNA on a single chromosome. If there is an abnormality in the gene, it can lead to certain diseases in children, such as cystic fibrosis, thalassemia, Down syndrome, meow cat syndrome, etc. If both parents are known to be carriers of the disease, they may pass on the disease to their children in the future.

This test is performed in the same way as PGS, but instead of chromosomes, the laboratory tests for specific genetic mutations, which can currently diagnose up to 125 recessive disorders and can easily screen for the sex of the baby. Through PGD, it can also be judged which embryos can cause children to suffer from this disease, which embryos will grow into normal children, and experts will choose which normal embryos will be transferred, which greatly improves the success rate of IVF, and also ensures eugenics and fertility from the source.

Generally speaking, the indications for the third generation of IVF mainly include two major parts.

In our daily life, we can meet or hear from time to time people with high-risk genetic diseases or birth defects, and we all know that the most fundamental disease is the genetic inheritance of parents. In general, the main types of genetic diseases are hemophilia, thalassemia, leukopathy, and so on. In addition, both mental and neurological disorders can be caused by genetics.

Therefore, in this case, the third generation of IVF brings an opportunity for parents. The third generation of IVF will monitor the embryos before the embryo transfer, so as to improve eugenics.

Second, there is also the condition that there is a chromosomal abnormality. Through the third generation of IVF technology, doctors can eliminate those embryos with chromosomal abnormalities before embryo transfer, so as to select excellent embryos for transfer through the principle of survival of the fittest, which has the advantage of fundamentally ensuring the baby's physical health after birth, and also brings hope to a family.

The first case: can the IVF sisters who have been transplanted multiple times without implantation be done?

Answer: Properly increase the implantation rate of the next transplant.

Every time there are good embryos, but every time they don't implant, why? Uterine environment? Immunity? Repel? What are my physical causes after transplantation? Pregnant women are full of remorse and always want to find a reason to muster up the courage to start the next round of entanglement.

Currently, the most advanced and definitive study of embryos is the screening of embryo chromosomes. If repeated attempts always fail, we can actually take a step forward – embryo testing is the key to everything**!

The second case: **Can mothers who are preparing for pregnancy have a sexual miscarriage do third-generation IVF?

Answer: It can make mothers have no worries during pregnancy.

There is a kind of bitterness of preparing for pregnancy, even more bitter than not getting pregnant! That's when the fetus stops. Whether natural or in vitro, there is still a 20% failure rate from a successful pregnancy test to the birth of a healthy child.

And this failure rate occurs more than 2 times, and it will be called ** abortion by doctors.

At a time when genetics is becoming more and more developed, doctors have recognized that 90% of repeated miscarriages within three months are due to abnormal staining of embryos.

Repeated fetal arrest, miscarriage, genetic diseases, and chromosomal problems like me can do three generations of test tubes, I have chromosomal problems, I did not check before conceiving the first child, but also fortunate that the child has no problems, now to have a second child, fetal arrest several times The doctor suggested that a chromosome should be checked, and the result was that it was not too late, my husband had a friend who had done IVF in Thailand, and the time was much shorter than here, and the probability was greater. I also chose her Dr. Ku, a well-known doctor in Thailand, who is more insurable, in my case, there may be many problems with screening, and they recommended that I take more conditioning drugs for a few months before IVF to improve the quality.

Hello, this can only be done if you comply with the relevant regulations.

There is also the need for economic allowability.

You can't do without money.

Three generations regardless of the population, if you want to give birth to a healthy baby, you can do three generations, especially if there is a family genetic disease, but now there are not many hospitals in China that can do three generations, you can consider going to the country to do, for example, Thailand, Malaysia, the United States and other countries can be.

Because the family reasons for infertility are different, not everyone needs to do three generations of IVF, and some people can do the second generation, and there is no need to do the third generation.

Generally, the main factors for doing third-generation test tubes are chromosomal abnormalities, immune infertility or genetic diseases of both husband and wife, etc., in addition to these factors, it is more than enough to do second-generation test tubes for other reasons.

This is not like some black intermediaries advertise, no matter what the situation is to do three generations, the success rate of the third generation is certainly higher, but the difference between the success rate of some people to do the third generation and the second generation is very small, of course, this needs to be carefully checked to determine.

And the most important point is that not everyone can do three generations of test tubes in China, and three generations of test tubes can generally only be done if it is confirmed that both husband and wife do have some kind of genetic disease, and they also need to be approved.

A lot. Now is the time to advocate a second child, many families want to have a second child, but miss the best childbearing age, natural pregnancy is more difficult, doing IVF is a good choice. Most families who want to have a second child want both children and daughters, so since they have done IVF, they will try to choose the third generation of IVF, screen the baby's gender, and realize the dream of having children and daughters.

As a practitioner in the test tube industry, the people who do the third generation of test tubes still hope that everyone can not use them!

Why? Most people need to do three generations of IVF in China, which shows that the population base of many families in China with health conditions or infertility is very large. Although this technology was born to target these situations as they occur.

Of course, a small number of people go overseas to do IVF because they need to use gender-selective technology (we are not allowed to choose in China).

Moreover, it is difficult to say how many people do the third generation of test tubes, after all, they will only choose if necessary, so we don't need to count this number. If you want to do three generations of test tubes, we will do it, if we can not do it, we will not do it, the cost of three generations of test tubes is still a lot of expenses for many families, and secondly, it is also very toss-up.

Shenyang Kyushu said that the third generation of IVF, also known as preimplantation genetic diagnosis (PGD), refers to the method of taking the genetic material of the embryo for analysis before the embryo transfer of IVF-ET, diagnosing whether there is an abnormality, screening healthy embryo transfer, and preventing the transmission of genetic diseases. Therefore, babies born through IVF techniques are less likely to have malformations.

The third-generation technique needs to be indicated, chromosomal abnormalities, after 2-3 test-tube failures.

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The third-generation IVF can achieve genetic screening and effectively avoid genetic diseases, while the third-generation IVF technology is divided into two types: PGD and PGS. PGD stands for Preimplantation Genetic Diagnosis, and PGS stands for Preimplantation Genetic Screening. The third-generation IVF process can also effectively ensure patient safety, and the details are as follows:

Stimulation: The expert will determine the appropriate stimulation plan according to the woman's age, ovarian function, basal follicle number and hormone level. During the use of ovulation induction drugs, real-time tracking and monitoring will be carried out to accurately grasp the specific development of follicles and the degree of women's response to ovulation induction drugs, and make timely adjustments to avoid adverse complications such as abdominal distention, ascites, and polycystic ovaries caused by the overuse of ovulation stimulation drugs, and at the same time ensure that enough high-quality eggs are obtained.

In addition, the use of stimulation drugs by reproductive medical groups has passed FDA regulatory certification, which is natural and non-existent, and can be metabolized in one menstrual cycle. Therefore, it is very safe.

Egg retrieval: The egg retrieval is accompanied by a professional anesthesiologist and operated by experts through advanced equipment, so the whole process will not feel pain and discomfort, that is, the whole process is safe**.

Blastocyst transfer: Frozen embryo transfer is generally performed, and this transfer method has become the mainstream of IVF assistance in Thailand. In the course of the IVF cycle, if the woman's body has any discomfort, or the uterus does not meet the requirements of pregnancy, then in this case, the frozen embryo transfer, that is, the embryos that have passed blastocyst cultivation and PGS PGD gene detection are cryopreserved in -196 liquefied nitrogen, and then the woman's body is treated and conditioned symptomatically, and then thawed and transplanted after recovery, so as to ensure the safety of the woman's body and the success rate of IVF.

Post-transplantation conditioning: Proper conditioning after blastocyst transfer not only helps to improve the implantation rate of the fetus, but also is an important way to ensure the safety of women's bodies. Therefore, in addition to injecting progesterone or HCG, experts also recommend that women must rest properly and maintain sufficient sleep; At the same time, good living habits and nutritious diet are also very important, follow the principle of eating small meals often, and eat more high-protein, high-fiber, and easy-to-digest foods.

Hello, the third generation of IVF refers to after the embryo is formed, before implantation in the uterine cavity, to diagnose whether there is a hereditary disease, to prevent the transmission of genetic diseases of an advanced technology, suitable for couples with chromosomal abnormalities, more advanced than the first and second generation of IVF.