What causes PCOS?

Polycystic ovary syndrome is a syndrome of hyperandrogenism or signs of hyperandrogenism, oligoovulation or anovulation, polycystic changes of the ovaries, not a single disease, metabolic disorders, and endocrine disorders.

At present, the cause of the disease is not clear, and it is more common in adolescents and childbearing. From the perspective of Western medicine, there are familial clustered genetic factors, polygenic genetic factors, environmental factors, or genetic factors induced by environmental factors.

From the perspective of traditional Chinese medicine, polycystic ovary syndrome is a dysfunction of the kidney, liver and spleen, which induces the dysfunction of the kidney-Tianqi-Chongren-uterine reproductive axis, resulting in oligomenorrhagia, postmenstrual leakage, amenorrhea, infertility, etc.

The causes of PCOS are complex and varied, and may be related to diabetes caused by insulin resistance, and in some cases it is caused by genetic factors, such as genetic mutations. Secondly, external factors, poor lifestyle, long-term dietary imbalance, and patients often taking drugs are also one of the common factors that induce the appearance of polycystic ovaries.

There is no specific cause for this disease, symptoms appear, and can only be achieved through lifestyle adjustments, **and medications**!

The main cause of polycystic ovary syndrome is polygenic hereditary disease, which runs familial, and the other is caused by environmental factors. So if you have polycystic ovary syndrome, this disease is not possible, and it is also lifelong. However, if you can live like a normal person after normal adjustment, that is, polycystic ovary syndrome, it will have an impact on pregnancy.

It is because of infrequent ovulation or anovulation, but it can be conceived normally by adjusting the endocrine, adjusting the diet, exercising, and inducing ovulation**. However, polycystic ovary syndrome is prone to hypertension, diabetes, coronary heart disease, and endometrial lesions. Therefore, if you have this disease, you must pay attention to the physical examination, pay attention to adjust the diet, and not be obese.

At present, there are two types of PCOS research: non-genetic theory and genetic theory.

Non-genetic theory.

It is believed that the intrauterine hormonal environment during pregnancy affects the endocrine status of adults in adults, and exposure to high concentrations of androgens during pregnancy, such as maternal history of PCOS, maternal congenital adrenal hyperplasia, poor hyperandrogen control, etc., is prone to ovulatory dysfunction after puberty.

Theory of genetics.

This theory is mainly based on the familial phenomenon of PCOS, familial ovulatory dysfunction and polycystic changes of the ovaries, suggesting a genetic basis for the disease. Hyperandrogenism and/or hyperinsulinemia may be genetic features of PCOS family members who also suffer from the disease, and insulin's role in promoting ovarian androgen production is also influenced by genetic factors or genetic predisposition. The prevalence of hyperinsulinemia in women and premature alopecia in men is increased in family members of oligoovulation, hyperandrogenism, and polycystic changes of the ovaries.

Cytogenetic studies have shown that PCOS may be X-linked recessive, autosomal dominant, or polygenic. The largest number of genes related to PCOS were found through genome-wide scanning, such as candidate genes related to steroid hormone synthesis and related functions, regulatory genes related to androgen synthesis, genes related to insulin synthesis, candidate genes for carbohydrate metabolism and energy balance, candidate genes for gonadotropin function and regulation, genes related to adipose tissue, and genes related to chronic inflammation.

In conclusion, PCOS** studies have not been able to confirm that the disease is caused by a certain gene locus or a gene mutation, and its onset may be related to the action of some genes under the action of specific environmental factors.

Polycystic ovary syndrome (PCOS) is a syndrome of endocrine and metabolic abnormalities related to genetics and environment. Polycystic ovary syndrome has three major characteristics: 1. Heterogeneity, with different clinical manifestations in different people; The clinical manifestations of the same person vary at different times.

2. Progressive. 3. Incompatibility, the exact condition of polycystic ovary syndrome is not known so far, and it is also unacceptable. Its **advocates individualization and synthesis**, including:

Lifestyle improvement, good lifestyle habits, reasonable diet, appropriate exercise, weight control, menstrual cycle adjustment, endometrium protection, ovulation induction**.

First of all, polycystic ovary syndrome is hereditary, and if the mother or maternal grandmother of the family has polycystic ovary syndrome, the chance of developing polycystic ovary syndrome is very high. Secondly, the occurrence of polycystic ovary syndrome is also related to lifestyle habits, especially staying up late, staying up late will lead to endocrine disorders in women, decreased estrogen secretion, and increased androgen secretion, resulting in anovulation in women and polycystic ovary syndrome. In addition, all diseases that cause endocrine disorders may be associated with polycystic ovary syndrome in women, such as hyperthyroidism.

From the perspective of genetic research on polycystic ovary syndrome, there are currently three conclusions, one is the disease caused by gene mutations, the other is companion inheritance, and the third is autosomal dominant inheritance.

Here are some of the symptoms:

There are varying degrees of hirsutism, usually predominantly sexual hair, dense and male-patterned.

Women in the reproductive period are infertile due to ovulation disorders.

Menstrual irregularities, which are also the main reasons for patients to visit the hospital. Amenorrhea is usually preceded by oligomenorrhea or oligomenorrhea.

A small number of patients can palpate the enlarged and tough ovaries by general ** examination, and most of them need to be confirmed by ultrasound examination.

Obesity symptoms are obvious.

Shulan Hospital** direction is clearly invited. Polycystic ovary syndrome (PCOS) is a common endocrine disease, with clinical manifestations such as oligomenorrhea, acne, hirsutism, obesity, infertility, etc. In addition, PCOS patients have an increased risk of developing diseases such as type 2 diabetes, metabolic syndrome, dyslipidemia, hypertension and endometrial cancer, which seriously endangers the physical and mental health and quality of life of women.

The exact pathogenesis of PCOS is still unclear and may be closely related to genetic, environmental, and psychological factors. It is believed that the diagnosis of PCOS should begin in adolescence, and it is necessary to eat a reasonable diet to prevent obesity.

The causes of polycystic ovary syndrome are as follows: 1. The most important is genetic factors. Polycystic ovary syndrome (PCOS) is familial and genetically related, and is inherited by autosomal dominant, sex chromosome-linked dominant, or caused by genetic lesions; 2. Environmental factors:

Hyperandrogens can cause polycystic ovary syndrome. Environmental compounds that resemble estrogen or androgens, such as bisphenol A or dioxins, can cause symptoms of irregular menstruation, infertility, multiple follicles, and hyperandrogenism. Some scholars have found that some drugs, such as sodium valproate for epilepsy and migraine, may cause significant increases in testosterone and insulin for obesity, but some scholars do not support this view; 3. Obesity and diet.

Obesity increases ovulation disorders, and obese patients have irregular menstruation and manifest themselves with hyperandrogenism. Excessive intake of saturated fatty acids can easily lead to polycystic ovary syndrome; 4. Psychological factors. Patients with polycystic ovary syndrome (PCOS) have lower physiological, emotional, social and mental health scores than normal individuals, and patients will have pathophysiological states of anxiety, depression, nervousness, sadness, and frustration of self-esteem, and eventually a vicious circle, with ovulation disorders, obesity and clinical manifestations of Kaohsiung.

There are many causes of polycystic ovary syndrome, the direct cause is genetic factors and endocrine disorders, and there are many lifestyle habits in life that can induce endocrine disorders, and often eating hot pot, fried, barbecue and other foods is easy to aggravate endocrine disorders.

Polycystic ovary syndrome has a great impact on women, and its occurrence is related to many factors, including familial genetic factors, obesity, hyperinsulinemia, long-term mental stress, adrenal gland dysfunction, etc.

Women with polycystic ovary syndrome are very concerned about the problems that have a serious impact on women's lives and work, and many people want to understand how polycystic ovary syndrome is caused in order to do a good job in the prevention and treatment of the disease. Here's how polycystic ovary syndrome is caused. The main factors that cause polycystic ovary syndrome are as follows:

1. In 50% of patients with adrenal dysfunction of polycystic ovary syndrome-PCOS, dehydroepiandrosterone (DHEA) and DHEA sulfate plant (DHEA) are elevated, the key enzyme activity of the adrenal gland for the synthesis of street body hormones is increased, and the sensitivity of adrenal cells to adrenocorticotropic hormone (ACTH) is increased and hyperfunction is related. The adrenal cortex is hyperactive, and excess androgen secretion can cause anovulation and symptoms similar to those of polycystic ovaries. 2. Insulin resistance and hyperinsulinemiaSome patients with polycystic ovary syndrome-PCOS, especially obese patients, can present with hyperinsulinemia and insulin resistance, suggesting that it is caused by insulin resistance.

There are many causes of insulin resistance, most of which are caused by the disorder of the information transmission system after the insulin receptor, and there can also be insulin receptor defects, hyperinsulinemia can inhibit the synthesis of hepatic sex hormone-binding globulin (SHBG), so that the free androgen in the body increases, and androgens can also increase LH secretion through the insulin receptor of the pituitary gland. 3. Abnormal regulation function of hypothalamic-pituitary-ovarian axis due to mental stress, yao substances and some diseases affecting the endocrine function of hypothalamic-pituitary gland, increasing the sensitivity of the pituitary gland to gn-Rh, secreting excessive LH and dysfunction of cytochrome as an androgen-forming enzyme in the ovaries, resulting in excessive androgen production by ovarian interstitium and follicular membrane cells. Hyperandrogen in the ovaries inhibits follicle maturation, causing the developing follicle to become atresia, unable to form dominant follicles, so that the normal secretion pattern of estrogen is interrupted, but many small follicles still secrete estrogen, so polycystic ovary syndrome-PCOS patients have both hyperandrogen and hyperestrogen, but excessive androgens are dominant.

The above introduces how polycystic ovary syndrome is caused, because polycystic ovary syndrome is complex, so it is necessary to understand what tests to do for polycystic ovary syndrome, and do relevant diagnostic examinations before **.