What are the 4 common causes of Parkinson s?

Tremor affects activity 10 to 20 years after onset, increasing in severity with age, impairing the ability to perform surprise activities, and peaking in the sixth decade after onset. Eighty-six percent of patients are between the ages of 60 and 70, and growing up can affect social activities and life skills, including writing, drinking, eating, dressing, speech, and manipulation. The greater the increase, the greater the impact on mobility.

There was no difference in the effect of tremor on gender. Many factors can affect tremor. Hunger, fatigue, agitation, and temperature (high fever, hot baths) can worsen tremors.

As with most involuntary movements, essential tremor resolves during sleep, and there have been individual reports of tremor persisting in sleep.

Parkinson's disease is a kind of degenerative nerve, necrosis of such a disease, at present, this disease is not possible, once Parkinson's disease is diseased, the patient's symptoms will gradually aggravate, and gradually lose the function of movement, so in this sense, it has no way, it can only be symptomatic, in this sense, it is a terminal disease, but this disease, its progress is relatively slow, the patient from the onset to the complete loss of motor function, can have more than ten years, Therefore, after he is active, the patient can still get a relatively large benefit.

Parkinson's disease, it is divided into motor symptoms and non-motor symptoms, motor symptoms have a cause and symptoms, the symptom is mainly to alleviate a series of symptoms of Parkinson's disease, such as increased muscle tone in Parkinson's disease, as well as bradykinesia, tremor, abnormal posture, gait These symptoms, we can use some dopa receptor agonists, or medopa, and cholinergic receptor blockers to improve the symptoms, the cause of the disease is for Parkinson's disease, The gradual reduction and apoptosis of dopamine neurons take such a series of neuroprotective methods.

Our common method is B vitamins, and there are some nerve growth factors that are used regularly to protect neurons, in addition to the cause and symptom of motor function, we will also carry out according to the non-motor symptoms of Parkinson's disease, patients will have psychiatric symptoms in the late stage, some emotional problems, so we will use some antipsychotic **, patients will also be bedridden, so there will be some complications similar to aspiration, pneumonia, and so on. A series of symptomatic approaches will also be taken for complications.

There are many causes of Parkinson's disease, Parkinson's disease has primary and secondary, primary may be partly related to genetics, in addition to the effect of the external environment, this is the result of a comprehensive effect, some secondary Parkinson's disease, we are also called Parkinson's syndrome, there are many reasons, mainly seen in the following aspects, the first is the poisoning factor, the most common is carbon monoxide poisoning, we often see gas poisoning, that is, carbon monoxide poisoning, which is more common in the north, We are now winter is coming again, many places need to make coal stoves and gas, at this time we must pay attention to ventilation, because carbon monoxide poisoning can easily cause diffuse damage to the brain, and it is easy to have Parkinson's syndrome.

The second infectious factor, usually in patients with encephalitis, develops Parkinson's syndrome, such as encephalitis A, which usually has an incubation period within several years of prognosis, followed by the gradual development of severe and persistent parkinsonism.

The third drug factor, some patients use antipsychotic drugs for a long time, such as rheumatazine or butyrocyte, may cause symptoms similar to Parkinson's disease, so many antipsychotic drugs, it will cause symptoms similar to extrapyramidal symptoms, that is, symptoms of Parkinson's syndrome, then the factors of brain diseases, some reasons may be due to multiple cavities in the brainstem or basal ganglia, such as cerebrovascular disease or other reasons, will also cause the substantia nigra dopa striatal pathway, This syndrome may occur, but this type of patient is often accompanied by pseudobulbar palsy, hyperreflexia, positive pathological signs, and symptoms of dementia.

In addition, some Parkinson's disease, in fact, has a very close relationship with age factors, the incidence of more than 65 years old has reached 2%, there are about 2 million patients in China now, the onset before the age of 40 is relatively rare, if the disease occurs before the age of 40, most of them may have a certain relationship with genetic factors, in addition to environmental factors and Parkinson's disease is also closely related, now epidemiological investigation and research results have found that the prevalence of Parkinson's disease, there are certain regional differences, So it's possible that there are some toxic substances in the environment that damage the neurons of the brain, which may also be an important part of Parkinson's disease.

The current mainstream view is that Parkinson's disease is the result of a combination of genetic factors, environmental factors, nervous system aging and other factors.

The main pathological change of Parkinson's disease is the degeneration and death of dopamine (DA) neurons in the substantia nigra of the midbrain, resulting in a significant decrease in the content of DA in the striatum. The exact cause of this pathological change is still unclear, but genetic factors, environmental factors, aging, oxidative stress, etc. may all be involved in the degenerative death process of PD dopaminergic neurons.

Parkinson's disease is a common degenerative disease of the central nervous system in middle-aged and elderly people, which is mainly due to the decrease in the synthesis of dopamine, a neurotransmitter in the brain, resulting in a series of neurological symptoms. Parkinson's disease is classified as primary, called Parkinson's disease, secondary called Parkinsonism, and hereditary. Primary Parkinson's disease is predominantly seen in older people and rarely in adolescents.

Secondary Parkinson's disease is mainly caused by drugs, poisoning, etc., and hereditary Parkinson's disease is mainly related to metabolic disorders and chromosomal recessive inheritance.

At present, the exact ** of Parkinson's disease is still unclear, and it may be related to age, genetics, environment, oxidative stress, and other factors. 1. Genetic factors: 10% of the patients had a family history, and the main susceptibility gene was cytochrome p45O2d6 gene, and most of the rest were sporadic; 2. Environmental factors:

It is mainly a neurotoxin, and the chemical structure of the toxin is similar to that of pesticides and herbicides; 3. Age factor: due to the aging of the nervous system in some patients, dopaminergic neurons in the substantia nigra begin to degenerate, and the number of dopamine neurons in the substantia nigra gradually decreases.

Parkinson's disease is a common degenerative disease of the nervous system, also commonly known as geriatric disease. Most of them are age-related, and as you get older, you are more likely to get Parkinson's disease. There are a variety of causes, and in fact multifactorial diseases are caused.

Some of them belong to environmental factors, such environmental factors, it has been found in foreign studies that exposure to toxic substances is easy to get Parkinson's disease, such as organic pesticides, and it has been found that some agricultural workers will have a greater chance of getting Parkinson's disease. Genetic factors have also been found in foreign countries, and some families will get Parkinson's disease, but there are not many people in this part, and family hereditary factors account for about 10%. With age, the organs of the nervous system degenerate, and the synthesis of substances is insufficient, which can easily lead to Parkinson's disease.

The main onset of Parkinson's disease is related to the death of dopaminergic neuronal lesions in the substantia nigra, and the causes of Parkinson's disease include genetic factors, and about 10% of patients have a certain family history. There are also environmental factors, such as frequent exposure to toxins from industrial agriculture, such as pesticides and herbicides, which can also easily lead to Parkinson's. There is also the aging of the nervous system, with the gradual growth of age, the substantia nigra dopaminergic neurons begin to gradually metamorphosis, which is also an important cause of Parkinson's.

With the exception of a small number of familial Parkinson's disease caused by genetic mutations, genetic predisposition predisposes patients to the disease. Once Parkinson's is present, patients will present with resting tremors and symptoms such as unsteady gait.

1 Genetic factors 5 10 Patients have a family history, including autosomal dominant or autosomal recessive inheritance, and the vast majority of patients are sporadic. The cytochrome P4502D6 gene may be one of the susceptibility genes for Parkinson's disease.

2 Environmental factors More than 80 patients with Parkinson's disease are sporadic cases. The factor of environmental toxicants plays an important role. Exposure to environmental toxins such as paraquat, mancozeb, herbicides, rotenone, trichloroethylene, etc., can increase the risk of Parkinson's disease.

Smoking, tea drinking, caffeine intake, and high serum urate are associated with a reduced risk of Parkinson's disease.

3 Aging factors This disease is more common in middle-aged and elderly people over 50 years old. As we age, dopamine levels in the body gradually decline, and only when the dopamine levels in the striatum decrease above 80 do the clinical signs of Parkinson's disease appear. Normal nervous system aging does not reach this level, so increasing age is only a contributing factor to Parkinson's disease.

Parkinson's disease is a neurodegenerative disease, which occurs mostly in middle-aged and elderly people, and the specific disease is not yet clear, and it is generally considered to be related to the following factors. 1.Degeneration of dopamine neurons in the substantia nigra caused by age, and a decrease in the number of dopamine neurons in the substantia nigra.

2.Genetic factors: There is a certain chance that Parkinson's disease will be inherited.

3.Environmental factors: Parkinson's disease may be related to the living environment, especially pesticide poisoning, gas poisoning, metals, industrial solvents, etc., which disrupt the synthesis of dopamine substances.

4.Underlying diseases such as high blood pressure, diabetes, and cerebral arteriosclerosis are also common causes of Parkinson's disease.

There are many reasons for Parkinson's disease, first of all, Parkinson's should be considered because of certain genetic factors, as well as environmental factors, and the interaction of various factors. For example, environmental factors, nervous factors, nervous system aging, and other factors may lead to the onset of the disease under the combined action of these factors.

Parkinson's causes are caused by a variety of self-causes, genetic causes, or some other factors, which can also lead to the occurrence of this disease.

Medical studies suggest that the occurrence of Parkinson's disease is related to the degeneration and death of substantia nigra dobana aminergic neurons, but what exactly causes the degeneration and death of these neurons has not been clear, and it may be related to a variety of factors, including genetic factors, environmental factors, nervous system aging, etc.

Genetic indication.

It is thought that 10% of patients have a family history of sporadic purity, and the vast majority of patients are sporadic.

Environmental factors. Industrial or agricultural toxins in the environment that are similar to the neurotropic 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP) molecular structure, such as certain pesticides, herbicides, rotenone, etc., may be one of the most important causes of Parkinson's disease.

Aging of the nervous system.

Some data show that after the age of 30, with age, the substantia nigra dopaminergic neurons begin to show degeneration, but not all of them lead to Parkinson's, aging is the most important factor in the occurrence of Parkinson's disease.

Multi-factor interactions.

Genetic susceptibility increases the likelihood of developing the disease, except in a small number of people with familial Parkinson's disease, except for a small number of people with familial Parkinson's disease.

It is due to the combined effect of environmental factors, aging of the nervous system and other factors that will lead to the onset of the disease.

There are three types of Parkinson's, and the main contents are as follows:

1. Parkinson's disease: It refers to Parkinson's disease, which refers to Parkinson's disease, such as resting tremor, increased muscle tone, abnormal posture and gait, etc., but the cause cannot be found by MRI examination of cardiovascular and cerebrovascular diseases. At present, the cause of Parkinson's disease is not clear, and it may be caused by a combination of reasons, such as a decrease in neuronal transmitters, and at this time, supplementation of transmitters**, such as medopa and levodopa, can improve the symptoms of Parkinson's disease patients by supplementing neuronal transmitters.

Receptor manipulators, such as senfrol and teshuda (piribedil extended-release tablets), improve Parkinson's symptoms through mobile receptors. Generally, Parkinson's patients are more common in their 50s and above, especially the older the Senyuan, the higher the incidence of Parkinson's disease. Some patients with early-onset Parkinson's have a positive family history, such as a large number of people with Parkinson's symptoms in their 30s and 40s, and there are genetic abnormalities at this time;

2. Parkinson's syndrome: refers to recurrent cerebrovascular diseases such as cerebral infarction, cerebral hemorrhage, poisoning factors such as gas poisoning, pesticide poisoning or heavy metal poisoning, and long-term use of antipsychotics. These patterns can cause parkinsonian symptoms such as resting tremor, movement disorders, dystonia, and postural abnormalities;

3. Parkinson's superposition syndrome: In addition to the damage to the extrapyramidal system, other systems are also damaged. For example, in the case of multiple system atrophy, in addition to extrapyramidal Parkinson's symptoms, the autonomic nerves are also impaired, often due to neurodegeneration.