Can PD1 cause vitiligo? Are PD1 side effects life threatening? How to deal with side effects caused

At present, PD1 drugs are becoming more and more widely used in clinical practice in China, and the toxicity management of drugs has become a compulsory subject for every clinician. According to the data of classical clinical research, grade 3-4 adverse reactions are maintained at about 10%, which is basically more than 40% compared with chemotherapy, mainly fatigue, rash and digestive tract reactions. Patients who have used immunotherapy drugs are still very well recognized for the safety of this class of drugs.

But nothing is complete. Due to the enhanced attack power of the T cells activated in the body, in some unexpected cases, the angry policeman may also attack his own tissue cells, which also forms autoimmune inflammation of various organs of the body, which affects an unexpectedly wide range, including endocrine adenitis, pneumonia, enteritis, hepatitis, etc. It is believed that this kind of autoimmune inflammation is also the most worrying place for domestic doctors to use.

There are cases of obvious myalgia, muscle weakness and even dysphagia after use. The neuromuscular toxicity caused by the use of PD1 can also be fatal, and the mortality rate is not low, so please treat it with clinical caution.

I really don't know about this, after all, this is a medical problem, and I suggest you find a professional.

This is medical knowledge, and it is recommended to consult a doctor.

Adverse reactions in immunity** are different from those of chemotherapy and radiotherapy, and are usually presented in the form of a series of inflammatory diseases that mimic autoimmune diseases, and these conditions are called immune-related adverse events (IRAes).

It has the following characteristics:

Affects one or more different organ systems.

Immune-related adverse events canOccurs during or after completion

Adverse events can range in severity from asymptomatic to severe or life-threatening, and they may accumulate over the course of **.

Combination** may increase the severity of adverse events.

Common adverse immune reactions

Common adverse immune reactions include rash, itching, fatigue, etc., and more serious ones will produce inflammation: pneumonia, pancreatitis, dermatitis, etc., and a very small number of patients will have fatal adverse reactions such as myocarditis and hypophysitis.

How to prevent & respond to adverse immune reactions

At present, there is no particularly effective prevention method, in order to ensure the safety of patients, hospitals specializing in immunization** will regularly monitor the relevant indicators of patients, and usually require patients to provide examination reports within the previous week.

How to deal with *** caused by PD1

According to the NCCN guideline criteria, adverse immune reactions are classified as grade 1 and 4, with grades 1 and 2 usually mild and dose reduction supplemented with targeted medications**. Grade 3 is moderate and requires discontinuation of the medication** and subsequent reassessment before the decision to continue immunization**. Grade 4 is severe, and the drug should be discontinued immediately**, and PD1 inhibitors should not be used again.

Through a large number of studies, it has been found that the *** of PD1 immune drugs is mainly due to the abnormal human immunity caused by blind medication. In the process of cancer, the choice of different immune drugs, the complexity of cancer primary and metastasis, and the differences in doctors' clinical experience on immunity will make the difference in the effect, and it is particularly important to find a professional doctor for immunization, and a reasonable combination of immune drugs can not only improve the effect of PD1 drugs, but also effectively reduce the response of drugs!

Generally speaking, PD1*** is not life-threatening, mild *** is tolerable, slightly more serious *** needs to contact the attending doctor, under the advice and guidance of the doctor to carry out the correct **, it can be relieved.

PD1-mediated pneumonia and immune myocarditis are prone to death. So how can we address the risk of death from PD1***? In the past years, Adventist Health has served many cancer patients who have received this kind of **, and understand that the *** of PD1 is mainly caused by blind medication and human immune abnormalities.

Therefore, Adventist Health believes that in order to solve the problem of PD1, it is necessary to use drugs.

First of all, it is essential to choose a professional doctor with experience in the use of PD1. At present, PD1 immune drugs have also been marketed in the mainland, but the market time is relatively short, and mainland doctors lack experience in the use of such drugs. In this case, you may wish to choose the guidance of a Hong Kong doctor.

PD1 immunotherapy has been marketed in Hong Kong for many years, and Hong Kong doctors have rich experience in the use of PD1 drugs, accurate dosage of PD1, and can provide professional guidance for cancer patients.

Secondly, in the past use of PD1 immune drugs, Hong Kong hospitals found that a reasonable combination of immune drugs can not only improve the best effect of PD1 immune drugs, but also effectively reduce the best response of drugs. As for the combination of drugs, it mainly depends on the tumor conditions of different tumor patients.

Vitiligo is related to factors such as the body's immunity and disease resistance, melanin self-destruction, trace element deficiency, trauma, chemicals, and so on.

Hello, vitiligo is a common acquired localized or generalized** depigmentation disease. The deficiency of trace element zinc in the body may induce vitiligo, in addition, there are many causes of vitiligo, which are related to genetics, neuropsychiatric disorders, endocrine disorders, reduced resistance, trauma, environmental pollution and other factors.

The main reason is low immunity in the body.

The basic cause of vitiligo is the loss of melanin in the body due to autoimmune deficiency, resulting in lesions.

There are many hair elements of vitiligo, and they are also very complex, and the common ones are genetics, patient diet, mental factors, etc., which bring a lot of harm to patients. Therefore, vitiligo patients are developing a good lifestyle habit.

You can take a closer look at whether the surface of the vitiligo is smooth and no dandruff, the vitiligo is pale white or milky white, if the boundary is blurred or spread towards the normal **, it may be a vitiligo wind, the specific situation needs to see the vitiligo before it can be diagnosed, vitiligo is a refractory disease, the biggest feature is that it is easy to spread, especially affecting the appearance and life, it is recommended that you go to the national regular specialist hospital for testing and treatment in time, so as not to delay the condition and the best period.

Vitiligo** is not very clear so far, and it can be roughly divided into the following nine general elements: genetic factors, psychiatric and neurological factors, chemical factors, tyrosinase, copper ion relative deficiency factors, infection factors, trauma factors, etc. Therefore, the hair elements of vitiligo are multifaceted.

According to clinical observation, the disease is mainly concentrated in the following eight aspects: 1. Industrial pollution 2, agricultural pollution 3, small food and beverages Small food and beverages have a significant impact on children's physical development and health 4, endocrine and immune dysfunction 5, trace element deficiency 6, neuropsychiatric factors 7, genetic factors 8, trauma: burns, scalds, knife stabs, mosquito bites, and white spots after infection.

Understand the incidence of vitiligo in the above eight points** and carry out effective prevention.

Thank you for the trouble to adopt!

Suggestion: Vitiligo does not cause death, and vitiligo mainly has the following four harms: (1) Vitiligo has a serious impact on the patient's normal study, employment, marriage, family, social interaction, etc.

2) There are many people in society who discriminate against vitiligo patients, which leads to a devastating blow to the self-esteem of the majority of patients, resulting in a series of mental disorders. (3) The latest medical research has confirmed that vitiligo patients have weak ultraviolet defense ability, and the incidence of ** cancer is much higher than that of normal people. (4) Vitiligo can induce a variety of diseases, such as pernicious anemia, alopecia areata, and psoriasis.

Malignant tumors, diseases such as bronchial asthma, rheumatoid arthritis and cataracts, as well as diseases such as concurrent hyperthyroidism.

Although vitiligo is a more serious disease, it does not cause death. However, when vitiligo develops severely, it can lead to some complications and may even cause cancer. It can be seen that the harm of vitiligo cannot be ignored.

It is recommended to go to a regular vitiligo hospital**.