How is tuberous sclerosis caused?

Tuberous sclerosis complex is a hereditary disease of the nerves, the main clinical feature of which is the appearance of sebaceous adenoma in the triangular area of the face, which is light red in color, like the size of a broad bean or the size of a pinpoint, and increases with age. In some patients, irregular depigmentation plaques will appear on the trunk and limbs, and in severe cases, patients will have seizures, mental retardation, hemiplegia, and deformities of the spine and fingers.

Ancillary tests: head CT or MRI, electroencephalogram, cerebral effusion, abdominal ultrasonography, electrocardiogram, chest x-ray or CT. The disease is mainly symptomatic, for example, infected patients can be resistant to infection**; Patients with seizures should be given antiepileptic drugs**; If there is a patient with cerebrospinal fluid obstruction, surgery**.

Tuberous sclerosis complex is mainly a congenital genetic succession or drastic genetic change. If one of the parents suffers from tuberous sclerosis, there is a 50% chance that the child will develop cancer due to intergenerational inheritance. At present, only 1 3 cases of tuberous sclerosis complex are known to be caused by intergenerational inheritance, and the other 2 3 patients with tuberous sclerosis complex are believed to be caused by congenital gene mutations, and the cause of gene mutations is still unknown.

Tuberous sclerosis complex is also known as sebaceous adenoma. Autosomal dominant inheritance has a family history, and severe cases can develop during the fetal period, leading to miscarriage. Preterm birth or death soon after birth is generally more common than preschool onset and progressively worsening.

Tuberous sclerosis complex is a chromosomal dominant neurological syndrome, mostly composed of ectodermal tissue organs, abnormal development, can appear brain ** peripheral nerves and other organs involved, patients will manifest facial sebaceous adenoma, seizures and mental retardation, and more males than females, causing tuberous sclerosis, the main cause of the disease is caused by heredity, the way of inheritance is autosomal dominant inheritance, familial cases account for about 1 3, so the child will carry this new mutated gene at birth.

An autosomal disorder that is inherited from one parent.

Tuberous sclerosis complex is an inherited disease that most patients inherit from their parents, and it is an autosomal dominant disorder. Through genetic testing, it was found that the disease was caused by mutations in the TSC1 gene and TSC2 gene. In addition to genetic factors, some patients can also get the disease due to genetic mutations caused by environmental factors. Genetic factors account for about 60% of the total.

This is an autoimmune disease, which is generally not, and gene mutation is a very long process, which requires a long period of gene misalignment to repair the dysregulation leading to gene mutation.

After the occurrence of nodular encephalosclerosis, it will mainly be clinical manifestations of facial sebaceous adenoma, seizures and mental retardation, which belongs to some more common autosomal dominant diseases.

1. Long-term drinking and smoking. Tuberous encephalosclerosis is a relatively common disease, mainly caused by poor lifestyle habits, if the patient's friends drink and smoke for a long time, it will often lead to brain damage in the patient's friends, and once it affects the function of the nervous system, it will occur due to brain atrophy and nodular encephalosclerosis.

2. Genetic factors. A large number of clinical practices have shown that patients with nodular encephalosclerosis have a certain family history, and the disease will also show autosomal dominant inheritance characteristics.

3. External harm. In daily life, if the patient's friend is injured by the outside world, especially if the brain suffers severe injury, it may also lead to the occurrence of nodular encephalosclerosis to a large extent, so it is recommended that the patient should pay attention to preventive measures to avoid the occurrence of this disease as much as possible.

4. Brain diseases. Patients with encephalitis, meningitis, and brain abscess, if they are not effectively controlled for a long time, may also have symptoms of nodular encephalosclerosis, and some people with cerebral schistosomiasis, neurocysticercosis or gas pesticide poisoning will also have nodular encephalosclerosis.

The occurrence of tuberous sclerosis complex is mainly caused by heredity, which can be divided into four types according to gene positioning: TSC1, TSC2, TSC3, and TSC2 mutations cause abnormal function of hamartoma protein and nodular protein, respectively, affecting their cell differentiation and regulatory function, resulting in abnormal growth and differentiation of ectoderm, mesoderm and endoderm cells. The mode of inheritance is autosomal dominant, and about one-third of the cases are familial, that is, the mutated TSC1 or TSC2 gene inherited from one parent; Sporadic cases account for about two-thirds of cases, i.e., patients are born with a newly mutated TSC1 or TSC2 gene and no family member has the disease.

Tuberous sclerosis complex can cause significant damage, and it is also easy to cause the growth of facial sebaceous adenoma, or cause seizures, so in the case of tuberous sclerosis, it will definitely cause serious damage to the patient's physical and mental health. Tuberous sclerosis complex occurs mostly in childhood, and after the onset of the disease, it needs to go through a series of ** to avoid aggravation of the disease and cause damage to the body. So, why do you get tuberous sclerosis?

Tuberous sclerosis complex is a genetic disease, mainly caused by chromosomal dominant inheritance, and has a familial nature, most of which are caused by the sudden inheritance of one or both parents. In general, there is a genetic condition that cannot be detected on its own during the fetal period, and it is necessary to wait until the onset of the disease in childhood to be investigated. Therefore, after the disease, it is necessary to take into account your own situation, and then according to the differences in individual conditions, through a variety of methods such as cranial plain radiograph, electroencephalogram, electrocardiogram, etc., after a comprehensive examination of the body, in order to further determine your own condition according to the results.

In general, during tuberous sclerosis, there are differences in the affected parts of the disease, resulting in different physical symptoms. It is mainly manifested by the growth of sebaceous glands on the face, the nervous system is damaged, which causes mental decline or epilepsy symptoms, and some patients even cause abnormal lesions in the lungs, bone marrow and even the heart. Therefore, after the disease, the body will be affected in many aspects and cause serious damage, and it is necessary to take surgery to do local ** according to the actual situation, or take or take drugs according to the doctor's instructions for conditioning and **, so that the condition can slowly improve or control the effect.

Osmotic crocoartular sclerosis is a kind of chromosomal dominant inheritance of neurological syndrome, mostly composed of ectodermal tissue organs, abnormal development, can appear brain ** peripheral nerves and other organs involved, patients will manifest facial sebaceous adenoma, seizures and mental retardation, and more males than females, causing tuberous plexus sclerosis, the main cause is caused by heredity, the way of inheritance is autosomal dominant inheritance, familial cases account for about 1 3, so the child will carry this new mutated gene at birth.

Tuberous sclerosis complex is caused by mutations in genes, mainly in the TSC1 and TSC2 genes, and 80% of patients find mutations in this gene locus. Nodular sclerosimism is a neurological syndrome that can affect multiple systems throughout the body, and the most common symptom is ** changes. 90% of patients with tuberous sclerosis have seizures, except for absence seizures, almost all seizure types can occur, and patients with tuberous sclerosis have seizures about 1 3 within one year of age, if not controlled as soon as possible, it can affect the child's intelligence and movement.

Seizures must be controlled as soon as possible after the diagnosis of tuberosclerosis is confirmed. Tuberous sclerosis complex is caused by mutations in genes, mainly in the TSC1 and TSC2 genes, and 80% of patients find mutations in this gene locus. Tuberous sclerosis complex is a neurological syndrome that can affect multiple systems throughout the body, and the most common symptom is ** changes.

90% of patients with tuberous sclerosis have seizures, except for absence seizures, almost all seizure types can occur, and patients with tuberous sclerosis have seizures about 1 3 within one year of age, if not controlled as soon as possible, it can affect the child's intelligence and movement. Seizures must be controlled as soon as possible after the diagnosis of tuberosclerosis is confirmed.

Tuberous sclerosis complex is an autosomal dominant neuro syndrome, most of which are caused by the abnormality of the organs of ectodermal fluid tissue, and the cranium, **, peripheral nerves, kidneys and other organs are affected.

The main clinical features are sebaceous adenoma of the face, seizures, and mental retardation. The cause of the disease is mainly due to genetic inheritance, familial cases account for about one-third of cases, depending on the affected area, patients can have different clinical manifestations, generally more local than childhood, more men than women. Patients may present with the following:

** Lesions, particularly sebaceous adenoma in the triangular region of the mouth and nose, are symmetrically butterfly-shaped, reddish or reddish-brown, pinpoint to fava bean size, hard, waxy papules, pressed to slightly fade.

Neurological damage, epilepsy is the main neurological symptom, accounting for 70% to 90% of the cases. Seizures begin in infancy and early childhood, and patients are mostly accompanied by mental retardation, emotional instability, naïve behavior, impulsivity, thinking disorders and other mental symptoms, and a few patients also have positive signs of the nervous system. 1.

Genetic factors:

Tuberous sclerosis complex is an autosomal dominant disorder that tends to run in families. Most of the cases are caused by the presence of disease-causing genes in the genes of one or both parents, which are then passed on to their offspring, in which case the disease is associated in the patient's family and is easy to be detected early.

2.Genetic Mutation Factors:

Although tuberous sclerosis complex is an autosomal dominant disorder, some patients do not have a case in their family. The onset of the disease is mainly due to the mutation of the patient's own genes. In the process of embryonic growth and development, some of its own genes have mutated, carrying new mutated genes, which in turn leads to the patient's manifestations of tuberous sclerosis, such as ** damage, seizures, etc.

: Tuberous sclerosis complex is mainly caused by genetic changes in the patient's body. The disease is a genetic disease, usually make the patient have symptoms such as vitiligo, epilepsy, mental retardation, etc., if the patient does not do it in time, as the condition continues to worsen, it will make the patient appear other physical alienation, thus affecting the patient's physical health.

Therefore, if the patient has this case of knotted arthropod sclerosis, he should go to the hospital for relevant examinations in time, and choose the corresponding drugs or methods for correction under the guidance of the doctor.

Tuberous sclerosis complex is also known as sebaceous adenoma. It belongs to the autosomal Nian Xun Jing dominant inheritance, there is a family history of the disease, and severe cases can develop the disease in the fetal period, resulting in miscarriage. Preterm birth or death soon after birth is more common than preschool, and the disease is progressively worse.

Sebaceous adenomas are small hemispherical papules the size of rice grains to lentils, bright red or yellowish-red, mostly palpable and distributed on the face, mainly in the nasolabial folds, cheeks and forehead.

Among them, the brownish red with dilated hair glands is red, and those with hard patches are induration, and those with normal skin color are white.

**About three-quarters of patients develop epilepsy after symptom onset, and it can also be accompanied by intellectual disability, cerebral tuberous sclerosis, glioma, fundus leukoplakia, retinal hemorrhage, cardiac malformations, multiple cysts of the lungs, pulmonary fibrosis, and cystic or fibrotic nephritis.

X-rays may show calcified nodules in the brain, gliomas in the cerebral cortex or ventricular walls, lung or bone changes, and abnormalities in electroencephalography and electrocardiogram. Diagnosis can be made based on a combination of CT and MRI scans and histopathology.

Most of the arthropic sclerosis is related to genetics, as long as the child's intelligence is normal, it is fortunate that there are no mental symptoms, and there is no good way to round and wither. It is an autosomal dominant neuro** syndrome, and there are also sporadic cases!

The reason for tuberous sclerosis is that this segment has necrosis and hardened over a long period of time, and if you do it, there will be a series of complications.

Tuberous sclerosis complex is an autosomal dominant disease, and its typical pathological changes are glial proliferation, sclerotic nodules widely occur in the white matter, basal ganglia and ependymium of the brain, and will be accompanied by calcium deposition. **The damage is manifested as facial sebaceous adenoma, and symptoms of nervous system damage can occur when it is painful, most of which are seizures, and intellectual impairment can also occur, dementia and so on.