Steatosis differs from the pathological changes of cellular edema 20

Steatosis is a morphological manifestation of intracellular lipodystrophy characterized by the presence of normally invisible fat droplets in the cytoplasm under light microscopy, or an increase in intracytoplasmic fat droplets.

Cellular edema, also known as "watery degeneration", is a form of reversible cell damage. The mechanism is mitochondria.

Impairment leads to decreased ATP production, which in turn leads to dysfunction of the sodium-potassium pump in the cell membrane, which further leads to excessive accumulation of sodium ions and water in the cell. After that, inorganic phosphate, lactic acid.

and the accumulation of metabolites such as purine nucleotides, which can increase osmotic pressure.

load, which further aggravates cellular edema, resulting in an increase in intracellular fluid.

Are you judging the steatosis and cellular edema of hepatocytes?

If the above is the case: you first need to understand that hepatocyte steatosis is divided into macrovesicular and microvesicular and microvesicular properties, and macrovesicular properties do not need to be distinguished from cellular edema, because a non-stained circle inside or outside the cell under LM is bullolar; The vesicles are multiple small vacuoles in the cell, similar in size to Cryptococcus; The microvesicles need to be identified, and there are many pale staining areas in the cells, but there is no swelling and whitening sensation of cell edema.

If differentiation is not possible, Sudan stain or oil red O staining can be used to identify cellular edema.

Water denaturation and steatosis are common protein denaturations, which are caused by changes in the three-dimensional structure of protein molecules under certain conditions, resulting in changes in their biological activity, functionality and solubility.

The reason for water denaturation is that under the conditions of high temperature, strong acid, strong alkali and high salt, water molecules interact with hydrogen bonds and van der Waals forces in proteins, resulting in the destruction of hydrogen bonds and van der Waals forces in protein molecules, thereby changing the structure of protein molecules. This denaturation often leads to degradation and inactivation of proteins.

The reason for steatosis is that under high temperature conditions, the hydrogen bonds in the protein molecules are broken, and the hydrophobic groups of the protein are exposed, which interact with the surrounding fat molecules to form an interaction force similar to hydrogen bonds, which leads to changes in the protein structure. This denaturation often occurs during food processing such as high-temperature roasting and frying.

Both water denaturation and steatosis will cause proteins to lose their biological functions, such as enzyme activity, structure, transportability, etc., so it is necessary to strictly control the heating and storage conditions during food processing and storage to ensure that the structure and function of the protein are not affected.

Steatosis tends to occur in the parenchymal cells of which organs:

a.Heart, shouting congratulations, brain, lungs.

b.Liver, kidneys, heart.

c.Intestines, liver, spleen.

d.Spleen, heart, liver.

e.Intestines, spleen, brain.

Correct answer: B

a) Concept:

When hypoxia, poisoning and mitochondrial ATP are produced, the function of the membrane sodium pump is reduced, and sodium and water enter the cell, resulting in excessive accumulation of water in the cell and swelling of the cell, which is called cell edema. It is a reversible collateral injury and can also progress to cell death.

b) Pathological changes in edema.

1.Naked eye: the volume of the organ increases, the capsule is tight, and the color becomes lighter.

2.Light microscopy: the cell volume increases, the cytoplasm is transparent and lightly stained, and in severe cases, the whole cell swells like a balloon, which is called balloon-like change.

Sex. It is commonly found in the heart, liver, kidneys, etc.

3.Electron microscopy: the matrix of the residual material is loose, the electron density is reduced, the mitochondria are swollen, the cristae become shorter and smaller, the endoplasmic reticulum is expanded, and the nucleus is dissolved.

Sugar bodies are detached and vacuole-like.

<> hepatocellular edema.

Hepatocyte steatosis.

Edema is intracellular edema, while steatosis is the accumulation of some abnormal lipid droplets in the interstitium.

Cellular edema: The increase of intracellular water and Na+ causes cell swelling, also known as watery degeneration and loose edema.

Intracellular degeneration includes aqueous degeneration and steatosis.

There are mucous changes, amyloidosis, and calcium salt deposition.

It can be glassy inside and outside.

The essence is necrotic degeneration is fibrinoid.

Edema is the swelling of cells, the thinning of the cytoplasm, and in severe cases, the so-called balloon-like changes.

Steatosis is the presence of multiple fat droplets inside the cell, which appear as vacuoles under the section.

Vitreous degeneration is the presence or absence of a structurally homogeneous red stain in the cell.