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Anonymous users2024-02-08The formula is as follows: low-density lipoprotein cholesterol (mg dl) = total cholesterol - high-density lipoprotein cholesterol - triglyceride 5, where "triglyceride 5" refers to the amount of very low-density lipoprotein cholesterol.
Because direct measurement of LDL cholesterol is too costly, and the detection of total cholesterol, HDL cholesterol, and triglycerides is more economical and simple, the formula is based on the levels of total cholesterol, HDL cholesterol, and triglycerides, where the default ratio of triglycerides to very-LDL cholesterol is fixed at 5:1.
However, clinical practice has confirmed that this method is prone to large errors when LDL cholesterol levels are low or triglyceride levels are high, and the test results are not accurate enough, often lower than the true level. And since eating affects the metabolic process of very LDL cholesterol, the activity of metabolism-related enzymes changes, so in order to improve the accuracy of the results, the estimation of LDL cholesterol levels according to the Friedewald formula method should require that blood be drawn in the case of the patient on an empty stomach.
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Anonymous users2024-02-07Total cholesterol is calculated based on lipoproteins or triglycerides.
Total cholesterol refers to the cholesterol contained in various lipoproteins in the serum, that is, the sum of bound cholesterol and free cholesterol. Since cholesterol in the serum is basically present in the lipoprotein in a bound state, it mainly represents the bound cholesterol.
Since it does not reflect the amount of each lipoprotein, it does not accurately reflect the amount of HDL cholesterol and LDL cholesterol.
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Anonymous users2024-02-06Total cholesterol cannot be calculated by the sum of the other three items because:
1. The most important components of blood lipids are: cholesterol and triglycerides, and triglycerides do not belong to cholesterol.
2. Blood lipids such as cholesterol and triglycerides are mostly transported in the form of lipoproteins combined with proteins, and some are free cholesterol.
There are four types of lipoproteins: HDL, LDL, VLDL, and chylomicrons.
Among them, the main component of LDL and LDL is cholesterol; The main component of very low-density lipoprotein and chylomicrons is triglycerides.
The so-called total cholesterol includes free cholesterol in addition to lipoprotein cholesterol such as high-density lipoprotein and low-density lipoprotein. Therefore, the normal reference value of the laboratory should prevail.
Cholesterol is also known as cholesterol. A derivative of cyclopentane polyhydrophenanthrene. As early as the 18th century, cholesterol was discovered from gallstones, and in 1816 the chemist Bencher named this lipid substance cholesterol.
Cholesterol is widely found in animals, especially in brain and nerve tissues, and is also high in kidneys, spleen, liver, and bile. Its solubility is similar to that of fat, insoluble in water, soluble in ether, chloroform and other solvents. Cholesterol is an indispensable and important substance in animal tissue cells, which not only participates in the formation of cell membranes, but also is the raw material for the synthesis of bile acids, vitamin D and steroid hormones.
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Subscription: Buying the new base and the old base is called subscription (**After the closed period, buy after opening the transaction). >>>More
A health manager will guide you:
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If this function is selected, the pop-up calculation is shown in Figure 6-23. After entering the data in the data frame, click the Liquid Production Index and Water Cut button, enter the liquid production index under different water content in the pop-up data box (Figure 6-23), and click the Calculate Display button to dismiss the judgment wheel, the production pressure difference under the same liquid production volume will not be flushed in the plot area on the left. The differential production pressure at the target volume is displayed above the calculation signal. >>>More
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