What causes cerebellar atrophy? What causes cerebellar atrophy?

Cerebellar atrophy may be due to an abnormally large number of repetitions of the onchromosomal nucleotide CAG, and because the CAG repeats are mostly present on exons, there is a long chain of glutamine in the protein expressed in its gene, which causes cell failure.

According to the chromosomes where the CAG repeat is located, it can be subdivided into different types of spinocerebellar atrophy. Among them, the frequency of SCA3 patients is the highest, about about that.

Some patients with spinocerebellar atrophy are caused by mutations in related genes, which require detailed identification of the pathogenic genes**. Spinocerebellar atrophy is highly susceptible to misdiagnosis for other neurological disorders, such as multiple sclerosis.

The precise diagnostic method is to identify the causative gene, which can distinguish the different types of the disease. Not all types of spinocerebellar atrophy are inherited, and children of patients can be tested for the disease-causing gene to know if they are at risk.

There are several clinical factors related to cerebellar atrophy, the more common cerebellar atrophy is often a senile change with age, in addition, cerebellar atrophy may also be caused by some diseases, the most common condition is senile degenerative diseases, such as Alzheimer's disease will manifest cerebellar atrophy to a certain extent; There are other neurological disorders that manifest as cerebral atrophy as they progress chronically.

1.Cerebral infarction: whether ischemic or hemorrhagic cerebral infarction, it can occur in the later stage, and patients with severe cerebral atrophy can form softening foci.

Although the number of people with multiple lacunar cerebral infarctions that progress to cerebral atrophy is small, most patients with cerebral atrophy can lead to dementia. Therefore, it is one of the causes of cerebellar atrophy.

2.Cerebellar atrophy of the cerebral hemispheres: due to massive cerebral infarction or hypoplasia due to vascular occlusion in the fetal or neonatal period. It is also an important factor in the common causes of cerebellar atrophy.

3.Cerebral calcification: patients with cerebellar atrophy often have concomitant leakage with ipsilateral vascular nevi. Diffuse calcified regression zones throughout the brain can lead to cerebral atrophy, dementia, or mental retardation.

4.After bacterial and viral infection: cerebellar atrophy is mostly secondary to meningitis, encephalitis, brain abscess and other sequelae.

Cerebellar atrophy The atrophy of the brain**, using the nerve repair system, the precise atrophy of encephalopathy, breaking through the tradition, to achieve the special treatment of infiltration plexus disease, so that the atrophy patients with brain sleepiness and screaming can recover movement disorders, stupidity, and poor memory.

Cerebellar atrophy has both physiological and pathological causes.

The physiological reason is mainly due to the increase of age in the body, the apoptosis of brain cells generally, which leads to a decrease in the number of brain cells, a decrease in the volume of the brain, a decrease in brain weight, and the symptoms of global brain atrophy, and the cerebellum can not avoid atrophy, which is a normal physiological phenomenon and is not necessary.

There are also patients with pathological phenomena, such as hereditary ataxia, when the patient's cerebellar atrophy will be obvious, the age of onset can be 20-30 years old or 50 years old, the patient shows poor limb balance, unstable gait, and some patients can not walk and need to do a wheelchair. In addition, carbon monoxide poisoning can also cause cerebellar atrophy; Traumatic cerebellar atrophy is also common; Drug poisoning can also cause cerebellar atrophy.

There are several causes of cerebellar atrophy:

First, hereditary, such as spinocerebellar degeneration, ataxia, dentate nucleus erythrocyus pallidus Lewy body atrophy, etc.

Second, degeneration, multisystem atrophy of the brain type.

Third, ischemia and hypoxia, which may be caused by carbon monoxide poisoning.

Fourth, drug poisoning, the most direct manifestation of phenytoin's drug poisoning reaction is cerebellar atrophy.

Fifth, inflammatory, sequelae of muscrebellia.

Sixth, alcoholism, alcoholic cerebellar degeneration.

Seventh, others, may be caused by neuroparaneoplastic syndromes.

Ataxia is the main clinical manifestation of cerebellar atrophy, and patients are unsteady, shaky, and have difficulty standing on their feet, generally cannot stand on one leg, have a staggering gait, and sway their legs from side to side when walking. Cerebellar atrophy is not a disease to be precise, but a neuroimaging manifestation that can be seen in some hereditary and degenerative diseases, as well as in an acute course, such as the later stages of acute cerebellitis or certain drug poisoning.

Cerebellar atrophy may be caused by hereditary or degenerative diseases, or it may be caused by certain acute processes such as the later stages of acute cerebellitis and drug intoxication.

Cerebellar atrophy is common in older people and is often a disease that cannot be **. There are many causes of cerebellar atrophy, and it can also be harmful to patients.

1. Common causes.

1. Genetic factors: It is a common cause of cerebellar atrophy, and people who suffer from this disease in their families have a greater chance of offspring suffering from this disease;

2. Cerebrovascular diseases: It is also a common cause of cerebellar atrophy, such as cerebral hemorrhage, cerebral infarction, etc., which will lead to the patient's brain parenchyma due to squeezing necrosis, or ischemia and hypoxia leading to cerebral atrophy or even necrosis;

3. Poisoning: For example, carbon monoxide poisoning leads to ischemia and hypoxia of the brain, drug poisoning, drug poisoning caused by excessive use of phenytoin, and cerebral vasoconstriction caused by alcohol poisoning, reduced blood flow, and hypoxia of the cerebral cortex, which will cause cerebellar atrophy for a long time;

4. Inflammation: the patient has acute cerebellitis and sequelae after **;

5. Neurodegeneration: For example, multi-system atrophy shrinks the brain, and the patient's cerebellar volume shrinks and becomes smaller.

There are many causes of cerebellar atrophy, which may be related to genetics, alcoholism, cerebrovascular accidents, and head diseases. 1. Genetic factors: hereditary spinocerebellar ataxia, due to genetic mutation, the common hereditary vertericherebellar ataxia pathogenic gene is the causative gene of the SCA3 subtype.

2. Alcoholism: Long-term alcoholism can cause alcoholic cerebellar degeneration, leading to nutritional metabolism disorders and cerebellar atrophy. 3. Cerebrovascular accident:

Generally, it will cause cerebellar hemorrhage or infarction, and local cerebellar atrophy will occur after **. 4. Head disease: For tumors and trauma to the head, it may also cause local cerebellar atrophy.

Patients are advised to eat more fresh, high-quality protein foods and less spicy, spicy, pickled and smoked foods. Clause.

1. Heredity. Heredity is one of the more common causes of cerebellar atrophy, often hereditary cerebellar ataxia, olive pontine cerebellar atrophy, etc., which are hereditary and often autosomal dominant inheritance.

Clause. 2. Insufficient cerebral blood supply.

When there is insufficient blood supply to the brain, it will cause ischemia and hypoxia in the brain, resulting in extensive diffuse lesions in the brain parenchyma, and the integration function of the brain will be affected, which will cause considerable atrophy.

Clause. 3. Suffering from tumors.

If the patient has a tumor, there may be paraneoplastic syndrome, and in the case that the tumor has not metastasized, it will also cause damage to other parts of the body, and the nerve is a part that is often violated, and the brain, spinal cord, peripheral nerves, etc. will be damaged, thus causing cerebellar atrophy.

Clause. 4. Infection.

If the patient is infected by viruses, bacteria, fungi, etc., it may cause a more serious infectious disease of the central nervous system, that is, encephalitis. Sometimes, although encephalitis is obtained, there may also be some sequelae, such as the patient's limb movement disorder, difficulty in swallowing, etc., which indicates that the cerebellum has atrophied.

Clause. 5. Alcohol poisoning.

Many people like to drink alcohol, especially after drinking a lot of alcohol, they may experience gibberish, dizziness, and vomiting, which are caused by the effects of alcohol on the nervous system. Those who drink too much alcohol, or drink high-concentration industrial alcohol, will also develop alcoholism, which will cause greater damage to the nervous system and even induce cerebellar atrophy.

Clause. 6. Trauma.

When a person's brain suffers from external damage, the central nervous system is affected, and cerebellar atrophy may also occur. Some people who take a drug for a long time, especially if taken in large amounts, may trigger acute drug toxicity, which can cause toxic cerebellar atrophy.

There are many reasons for the formation of cerebellar atrophy, some are congenital, and some are acquired. In daily life, pay attention to strengthening the protection of the brain, and if cerebellar atrophy is found during the examination, it is also necessary to pay attention to it, and carry out active and regular ** as early as possible.

Tonifying the marrow and strengthening the brain soup "**Cerebellar atrophy banquet takes this, ataxia is divided into three steps:

The first step: to achieve blood replenishment - hematopoiesis - blood nourishment by replenishing blood, replenishing qi, generating blood, filling essence and replenishing blood, removing stasis and renewing, etc. As a result, the qi and blood are abundant, the muscles and veins are nourished, and the weakness and atrophy of the world are improved.

Step 2: Strengthen the spleen and stomach; For those with imbalance of yin and yang, they should be given to attack and make up for deficiency, rise and fall, and adjust the balance of yin and yang of the patient through the method of temperature and cold, so as to eliminate symptoms such as dysphagia, choking on food and water, and slow reaction.

Step 3: Nourish yin and benefit the kidneys, fill the essence and marrow, strengthen the muscles and bones, improve the blood supply to the brain, enhance intelligence, and restore limb function.