What is the best way to deal with ALS?

There is no particularly effective method and can only be controlled with drugs.

ALS is also known as motor neuron disease, the latter name is commonly used in the United Kingdom, Charcot disease in France, and Lou Gehray disease in the United States. In China, amyotrophic lateral sclerosis and motor neuron disease are commonly mixed. It is caused by damage to the upper and lower motor neurons, resulting in gradual weakness and atrophy of the muscles including the bulbar (the bulbar refers to the part of the muscles innervated by the medulla), limbs, trunk, chest and abdomen.

The condition of amyotrophic lateral sclerosis is still unknown. In 20% of cases, it may be related to heredity or genetic defects. In addition, some environmental factors, such as heavy metal poisoning, can cause motor neuron damage. The main theories of the causes of motor neuron damage are:

1. Neurotoxic substances accumulate, glutamate accumulates between nerve cells, and over time, causes damage to nerve cells.

2. Free radicals damage nerve cell membranes.

3. Lack of nerve growth factor makes it impossible for nerve cells to continue to grow and develop.

Extended Materials. For ALS, there are four core points.

1. Ensure adequate nutrition.

Difficulty swallowing may result in a decrease in the amount of food to eat, and the already fragile motor neurons will be "not able to eat" and will be lost even more. Gastrostomy surgery (i.e., placing a tube in place in the abdomen to address the patient's nutritional concerns) may be considered when the patient has dysphagia and the general condition is acceptable, but it is difficult to complete if the procedure is delayed until the body is extremely weak.

2. Ensure breathing.

Weakness in the muscles responsible for breathing can make it difficult for people to breathe. Depending on the test of lung function, a noninvasive ventilator may be used to help with breathing and also help prolong survival.

3. Give drugs**.

At present, many drugs are still being investigated, and riluzole has been shown to prolong patient survival and should be used as soon as the diagnosis is confirmed.

4. Meticulous care.

The care of motor neuron disease can be described as a "long-term war of attrition", in which patients have no strength to cough up sputum, difficulty swallowing, easy to choke and cause pneumonia, inability to turn over and cause pressure ulcers, and huge psychological pressure, all of which require careful care to avoid as much as possible. Nursing care is one of the most important aspects of this disease. It is worth mentioning that ALS does not need to be overworked, because overworking the muscles will increase the burden on motor neurons.

ALS is most commonly symptomatic**, but medications** can also be used.

Symptomatic**, appropriate exercise. For example, pay attention to the function of the respiratory tract and digestive tract. If there is a lot of saliva, some antihistamines can be given; If there is a lot of phlegm, you can give nebulized inhalation and some expectorants; If you feel depressed, you need to be antidepressant**.

In addition, it is necessary to turn the patient over more often to avoid pressure ulcers. Second, drugs**, which are currently considered to be effective, include riluzole or cocktails**, such as edaravone, butylphthalide, coenzyme Q, etc., which may delay the progression of the disease. The prognosis is mainly a lung infection.

Therefore, the prevention of complications, the reduction of the incidence of lung infections, and the prolongation of their life cycle are the main ones.

If you want to prevent frostbite, avoid infection with the human immunodeficiency virus, avoid long-term exposure to aluminum, and take care of vitamin B1 supplementation.

At present, there are two main methods for ALS: drug and non-drug.

In terms of drugs, in addition to the well-known drug riluzole, there is also a new drug called edaravone, which has a mechanism of action to scavenge free radicals, which is currently mainly used in cerebrovascular to eliminate free radicals generated in cells after ischemia and protect blood vessels. Due to its strong clearance ability, it has a certain effect on alleviating endoplasmic reticulum dysfunction and protecting nerves from ischemia and hypoxia injury. Compared with riluzole, edaravone is currently covered by medical insurance, and compared to riluzole's high out-of-pocket cost**, patients are more likely to afford, so I am optimistic about the prospect of edaravone in China**ALS.

In terms of non-drugs, there are currently two main effective means:

1.Early nutritional support, we know that ALS is an energy-wasting disease, so early nutritional support has a significant effect on the prognosis of the disease and the patient. Before the symptoms of ALS appear, the body's internal energy will enter a state of high consumption.

Even if it sits still, its energy consumption is larger than normal. After the patient gets the disease, if the patient is anxious and depressed, he does not eat well and sleep well, the energy expenditure will be greater, which is a negative impact on the disease and often accelerates the development of ALS.

2.Respiratory support, in the process of the occurrence and development of ALS disease, the patient's respiratory function and hypoxia status in the body are very closely related to the prognosis, such as the latest research shows that those patients with nocturnal sleep breathing disorders (such as sleep apnea) will exacerbate the development of ALS, so for patients we often recommend the early use of home non-invasive ventilators, which does not mean that the patient's breathing has problems, but is a positive improvement of the potential chronic hypoxia state ** and mitigation means, thereby delaying the progression of ALS disease ** Function.

ALS generally refers to amyotrophic lateral sclerosis, and ALS must be diagnosed and differentiated as soon as possible, neuroprotective and support should be given as soon as possible**, such as lirutai and other drugs, and regular follow-up should be adhered to.

1.So so**.

Support**: symptomatic**, appropriate exercise. For example, pay attention to the function of the respiratory tract and digestive tract.

If saliva is profuse, a small amount of antihistamine may be given; If there is a lot of phlegm, nebulized inhalation and phlegm-reducing drugs can be given; If you have a depressed mood, you should take anti-depression** and so on. In addition, it is necessary to turn over more often to prevent pressure sores from occurring. If eating disorders occur, nasogastric feeding or percutaneous gastrostomy (PEG) is given.

2.Special**.

At present, the only internationally recognized and FDA-approved** amyotrophic lateral sclerosis drug is Rilutek, and it must be used as soon as possible.

3.Breathe**.

When breathing is difficult at first, regular oxygen or a dual positive pressure ventilator (BIBAP) can be used to help breathing, and if further respiratory failure occurs, a tracheostomy is required and an artificial ventilator is used.

Mixed form of upper and lower motor neuron disease. Usually the first symptom is hand muscle weakness and atrophy, which generally starts from one side and then spreads to the opposite side, and with the development of the disease, there are mixed symptoms of upper and lower motor neuron damage, which is called amyotrophic lateral sclerosis. In the late stage of the disease, the muscles of the whole body are emaciated and atrophied, so that they cannot raise their heads, have difficulty breathing, and are bedridden.

The disease usually occurs between the ages of 40 and 60, and about 5 to 10% have a family history, and the course of the disease varies in speed and progression.

ALS is a neurological disease that is difficult to treat in medicine, which has many adverse effects on the life and health of patients. Therefore, everyone is more concerned about the **way, how should ALS be**?

ALS can be used in a different way, and drugs are used for patients with stiff muscles and limited mobility. ALS is caused by damage to neurons, and many patients lose control of certain parts of the body due to nerve damage, and the joints become stiff and involuntarily spasm. Due to the loss of control of the nerves around the mouth, the mouth cannot be closed and drooling frequently.

For this part of ALS, anti-stimulant drugs and muscle-loosening drugs can be used to relieve symptoms.

Some ALS patients have swallowing dysfunction and require surgery**. Swallowing dysfunction is a condition in which the patient chokes on eating or drinking, and in severe cases, cannot swallow on his own. It is easy to cause symptoms of malnutrition and anemia, and patients will also have the risk of suffocation, and it is easy to die suddenly.

Therefore, a gastric tube should be surgically inserted to help the patient eat and ensure normal body function.

People with ALS may also have breathing obstruction, difficulty breathing, and inability to breathe involuntarily. Therefore, this part of ALS patients need long-term oxygen inhalation** to ensure that the oxygen in the body and blood is sufficient to maintain normal body functions. If you do not want to stay in the hospital for a long time**, it is recommended to use a home ventilator to help the patient with oxygen**.

ALS includes support and medications.

1. Support: Symptomatic and appropriate exercise. Pay attention to the function and patency of the respiratory and digestive tracts, and if there is an increase in oral secretions, antihistamine drugs can be used; Nebulized inhalation drugs can be used if there is a lot of phlegm, and if there is a shortness of breath, resulting in dyspnea and hypoxemia, a ventilator can be used to assist breathing.

In addition, the patient should be turned over more often to avoid bedsores.

2. Drugs**: For ALS, you can use drugs such as riluzole tablets**, and you can also try to apply neurotrophic factors, antioxidants, free radical scavengers, and pro-metabolic drugs to improve symptoms, such as vitamin E, vitamin C, coenzyme Q10, edaravone, idebenone, etc.

ALS is a disease that cannot be improved, but the quality of life of Chi Luchang patients can be improved through support and drugs, and the progression of the disease can be delayed. For patients with ALS, early diagnosis and early ** are required.

Hello ALS refers to motor neuron disease. The disease is a degenerative disease that affects motor nerves alone, including upper and lower motor neurons. There is currently no effective ** measure for ALS.

ALS includes support and medications.

1. Support: Symptomatic and appropriate exercise. Pay attention to the function and patency of the respiratory and digestive tracts, and if there is an increase in oral secretions, antihistamine drugs can be used; If there is a lot of phlegm, nebulized inhalation drugs can be used, and if there is dyspnea, resulting in dyspnea and hypoxemia, a ventilator can be used to assist breathing.

In addition, the patient should be turned over more often to avoid bedsores.

2. Drugs**: For ALS, you can use drugs such as riluzole tablets, and you can also try to use neurotrophic factors, antioxidants, free radical scavengers, and pro-metabolic drugs to improve symptoms, such as vitamin E, vitamin C, coenzyme Q10, Zhenzheng edaravone, idebenone Chi Luchang, etc.

ALS is a disease that cannot be improved, but it can be used to improve the quality of life of patients and delay the progression of the disease through support and drugs. For patients with ALS, early diagnosis and early ** are required.