What are the late symptoms of ALS?

Typical symptoms: upper and lower motor nervous system involvement is the main manifestation. Common symptoms:

Muscle weakness, muscle atrophy, and fasciculations are manifestations of lower motor nervous system involvement; Hypertonia, hyperreflexia, and positive pathological signs are the main manifestations of upper motor nervous system involvement. Other symptoms: the presenting symptom can be a variety of manifestations depending on the patient.

Most patients have asymmetrical local limb weakness, such as stiff walking, procrastination, easy falling, and inflexible finger movement. Bulbar symptoms such as dysphagia and dysarthria. A small number of patients present with respiratory symptoms.

ALS, also known as motor neuron disease, is a chronic condition.

The clinical characteristics of this disease are: 1. Insidious onset and progressive aggravation, mainly manifested as distal limb muscle atrophy, weakness, hypertonia, fasciculation, difficulty in moving, bulbar paralysis, dysarthria, choking on eating, breathing and swallowing disorders, hyperreflexia and positive pathological features. There is usually no sensory impairment.

2. The disease is most affected by middle-aged people, mostly between 40-50 years old, but it can also occur in childhood and after the age of 70. There are 2-3 times more males than females, and some patients have a positive family history, usually inherited in an autosomal dominant manner.

The earliest symptoms of motor neuron disease are:

1. Asymmetrical weakness of the limbs, or arthria, the onset of the upper limbs mostly starts from the weakness of the shoulder, and sometimes the distal weakness is often more obvious after a slight local injury, which is manifested as the weakness of holding objects, approximately.

Thirty-five percent of patients begin in the upper extremities, and about 40 percent begin in the lumbar spinal cord, and these patients claudible due to unilateral foot drop or difficulty standing due to weakness.

2. Early muscle cramps are common, and they are mostly in the proximal and distal muscles of the lower limbs affected. Muscle beats can be a cause for concern, and sometimes muscles beat months before weakness and muscle atrophy.

3. With the development of the course of the disease, almost all patients with the onset of limbs will have bulbar symptoms, and the weakness will be further aggravated, and the muscle beating will become insignificant. Conversely, people who develop bulbar symptoms end up with extremity symptoms.

Patients with ALS will have severe and life-threatening symptoms in the late stage, as follows:

First, the patient's general weakness is particularly obvious, he cannot walk, his upper limbs cannot be lifted, and even raising his head may be very difficult, which is manifested as a symptom of myasthenia gravis, requiring a long stay in bed until the final complete paralysis.

Second, the patient will have a pronounced flesh throbbing throughout the body, accompanied by significant muscle atrophy and limb bi, and weight loss until extreme emaciation.

Thirdly, patients will have dysarthria, slurred speech, difficulty swallowing, choking on drinking water, etc.

Fourth, some patients will also affect the respiratory muscles, resulting in lack of breathing, resulting in respiratory failure, which directly affects life.

In short, the late symptoms of ALS are mainly similar to similar myasthenia gravis.

ALS people, on the wild orange is a common motor neuron disease is amyotrophic lateral sclerosis patients often appear, problems with the locomotor system, the earliest symptoms may be the patient's muscle jump, the position is not fixed, and then gradually appear hand muscle weakness, some patients, is mainly diseased, can be manifested as weakness of the lower limbs accompanied by muscle atrophy.

There are also some patients who can't afford to be sick, and if the muscles of the throat appear profitable, the patient will have dysarthria, dysphagia, etc., which will gradually worsen.

Amyotrophic lateral sclerosis, also known as ALS, is a type of motor neuron disease (MND) that affects the upper motor neurons (brain, brainstem, spinal cord) and the lower motor neurons (cranial nerve nuclei, anterior horn cells of the spinal cord) and their innervated trunk, limbs, and head and face muscles. So, what is ALS? What are the ** of ALS?

Below, let's find out with 360 common sense network!

Table of Contents of this article. 1. What is ALS?

2. What are the ** of ALS?

What is ALS? What are the ** of ALS?

What is ALS?

ALS, also known as amyotrophic lateral sclerosis, is a chronic neuronal disease caused by damage to motor neurons on the motor cortex and motor neurons in the spinal cord and brainstem, which causes gradual weakness and atrophy of the muscles of the limbs, trunk, chest, and abdomen, thereby affecting movement, communication, swallowing, and respiratory functions, and eventually death. The disease is still not available, and it can be combined with ** to improve symptoms and improve the quality of life of patients.

What is ALS? What are the ** of ALS?

What are the ** of ALS?

1. Infection and immune factors.

Some scholars believe that the pathogenesis of amyotrophic lateral sclerosis is related to the administration of viruses and human immunodeficiency virus.

2. Nutritional disorders.

Amyotrophic lateral sclerosis after gastrectomy has been reported, suggesting that dystrophy may be related to the onset of the disease.

3. Neurotransmitters.

Recent studies have suggested that the neurocytotoxic effects of excitatory amino acids (mainly glutamate and aspartic acid) play an important role in the pathogenesis of amyotrophic lateral sclerosis.

4. Genetic factors.

Most of the disease is sporadic, some patients have a family history, and the inheritance mode is mainly autosomal dominant, and the most common pathogenic gene is copper (zinc) superoxidase.

5. Metallic elements.

Some scholars believe that the onset of amyotrophic lateral sclerosis is related to certain metal poisoning or deficiency of certain elements. Variations in metallic concentrations in the environment may be responsible for the geographically high incidence of amyotrophic lateral sclerosis in some regions.

What is ALS? What are the ** of ALS?