Does taking metformin and ventilla in early pregnancy have a big impact on fetal malformations?

Since it's so difficult to conceive, let's take a gamble.

I also had a fever in the first trimester and took a lot of teratogenic drugs.

Later, I consulted the eugenics specialty of many provincial hospitals.

Doctors advise against it, but they also say that in the first trimester, when the follicles are not implanted, they do not yet have a blood connection to the mother, so they have fewer effects. So.. You'd better calculate when you got pregnant, and whether the follicles didn't implant.

In addition, doctors also say that the effect of the drug on the fertilized egg during this period is immediate. That is, if there is an impact, there will be a spontaneous miscarriage. If you don't have a miscarriage, it's basically no effect.

I wasn't young anymore, and it was a long time before I got pregnant. So.. Bet.

Later, everything was normal during pregnancy, and I was scared for 10 months. Gave birth to a very healthy big fat boy.

Blessing...

Generally speaking, metformin is used for non-insulin-dependent diabetics who are not satisfied with diet control alone, especially for obese patients, and the use of this class of drugs not only has a hypoglycemic effect, but also may have a weight loss effect. It is effective in some cases where sulfonylureas are ineffective, such as when combined with sulfonylurea hypoglycemic drugs, there is a synergistic effect, and the effect is better than that of each other. Alcoholics and pregnant women should not use this product.

However, it is not a contraindication to the drug. In addition, Vindia (rosiglitazone maleate tablets) is a type 2 diabetic patient who is still not satisfied with the results of diet control and exercise**. This product can be used alone, or in combination with sulfonylureas or biguanides** Sulfonylureas alone or biguanides for patients with type 2 diabetes mellitus with poor glycemic control.

The use of this drug in pregnant and lactating women is not clear. So it should be said that the two drugs you are taking will not affect the child too much, and you should be able to keep the child. It is recommended to do four-dimensional color ultrasound deformity at 16 weeks to 26 weeks of pregnancy.

So that you can rest assured. Good luck!

It shouldn't have much of an impact, because someone else has done the same.

Yes, rosiglitazone is best used with GlaxoSmithKline, and their company has released a metformin rosiglitazone tablet, the effect is better than the combination of these two drugs, this product can significantly reduce hyperglycemia when combined with metformin or sulfonylureas, and the efficacy is better than that of a single drug, which is consistent with the synergistic effect of combined drugs on blood sugar control.

Health Canada advises other important restrictions on the use of rosiglitazone include: rosiglitazone should not be used concomitantly with insulin; Rosiglitazone cannot be used in triples**, i.e. rosiglitazone cannot be used in combination with metformin and sulfonylureas.

Since September 2010, the European Union, the FDA, and the China Drug and Food Administration have successively issued notices on the suspension of the use of rosiglitazone, changing the relevant precautions, including that rosiglitazone can no longer be used alone, unless metformin cannot be used to lower glucose;

Therefore, it is best not to use both at the same time.

Yes, biguanides inhibit hepatic glucose output and improve the sensitivity of peripheral tissues to insulin, and thiazolidinediones reduce insulin resistance.

Thiazolidinediones are mainly rosiglitazone and pioglitazone in use now, rosiglitazone has the risk of cardiovascular disease, Vindia has been removed from the market in Europe and the United States, Tailuo is said to have not done the corresponding clinical trials at all to report whether there is a corresponding risk, pioglitazone has a carcinogenic risk, and France has stopped using it. Metformin can also be combined with other hypoglycemic drugs, if the kidney function is okay.

Can be taken at the same time. The combination of these two drugs can control type 2 diabetes.

Metformin is very effective for obese diabetes, but not for non-obese types...

Hello! Your illness cannot be easily judged, so it is best to ask for a visit to the hospital.

Chief Physician of Tianjin Medical University General Hospital-Department of Internal Rock Secretion-Fan Jiyuan.

The development of diabetes mellitus should be individualized. All patients should start with the lowest recommended dose. Further increase in the dose of this product should be based on the detailed monitoring results of adverse events related to fluid retention (see [Precautions], heart failure and other cardiac events for details).

The starting dosage of this product is 4 mg daily, one tablet once daily. After 8 to 12 weeks**, if fasting blood glucose control is not ideal, the dosage can be increased to 8 mg of this product alone or in combination with metformin. Monotherapy**:

The usual starting dosage for this product is 4 mg daily, one tablet once daily. Clinical trials have shown that taking 4 mg twice a day can significantly reduce fasting blood glucose and HbA1c levels. Combination medications:

If this product is added to the existing **, the original dosage of sulfonylureas or metformin should be maintained and this product should be added. Combined with sulfonylureas: When combined with sulfonylureas, the starting dosage of this product is 4 mg daily, once a day, one tablet each time.

If the patient has hypoglycemia, the dose of sulfonylureas should be reduced. Combined with metformin: When combined with metformin, the usual starting dosage of this product is usually 4 mg daily, once a day, one tablet each time.

During concomitant medications, there is no need to adjust the metformin dose due to hypoglycemia. Maximum recommended dose: The maximum recommended dose of this product is 8 mg per day, which can be taken in a single dose or in 2 parts, and clinical studies have shown that this dose is safe and effective when taken alone or in combination with metformin.

When this product is used in combination with some other specific drugs, the dosage of this product may need to be adjusted (see [Precautions], [Drug Interactions] and [Pharmacokinetics]). Elderly patients do not need to adjust the dosage due to age when taking this product. Patients with renal deficit damage do not need to adjust the dose of this product alone; Metformin is contraindicated in patients with kidney damage, so for such patients, this product should not be used in combination with metformin.

This product is not recommended in patients with type 2 diabetes mellitus if they have clinical manifestations of active liver disease or elevated serum aminotransferases (times the upper limit of normal for ALT). Patients should have their liver function tested before taking this product for the first time. If there is any clinical need, regular follow-up should be done as prescribed.

At present, there is no information on patients under 18 years of age to take this product, so it is not recommended for children to take this product. This product should not be broken and taken as a single tablet.

Yes, the trade name is just a factory production brand name, as long as it is this ingredient.

For example: morpholine (domperidone tablets), if you buy domperidone tablets, it is very expensive, but domperidone tablets are very cheap, the ingredients are the same, and the effect is the same.

Similarly, when the national medical insurance is reimbursed, if the morpholine is used, it will not be reimbursed, and if it is domperidone, it will be reimbursed, because the effect is the same, why use expensive ones, and burden the country, when the doctor prescribes the medical insurance drug policy, there will be more of this requirement, and the brand name of the drug will not be prescribed.