What are the best drugs for lowering uric acid?

1. Benbromarone.

High uric acid. It is because of the body's excretion problems and the inability to excrete uric acid normally, so you can choose benzbromarone, which can promote the excretion of uric acid from the body and reduce the uric acid content, but if the kidney function is insufficient.

It is better not to take benzbromarone to avoid harming the body.

Allopurinol. 2. Allopurinol.

Another reason for high uric acid is that more uric acid is generated, which will cause high uric acid in the body if it exceeds the body's excretion.

Febuxostat. 3. Febuxostat.

This is a selective inhibitor of non-purine xanthine oxidase, mainly to inhibit uric acid synthesis, which can effectively reduce the uric acid content in the serum, febuxostat for gout.

It can be taken by patients as well as those with hyperuricemia.

Probenecid. 4. Probenecid.

There is also a kind of uric acid-lowering drug is probenecid, many people use probenecid to lower uric acid, probenecid is mainly to promote the excretion of uric acid from the body, inhibit uric acid absorption, so that the body's uric acid content will decrease, to avoid harm to the body, but before taking probenecid, you need to drink more water, so that it will be smaller.

Normally, uric acid production and clearance are in dynamic equilibrium, maintaining serum uric acid levels within the normal range. Either cause increased uric acid production or decreased excretion, or both, can cause an increase in serum uric acid levels, which can lead to gout.

According to the principle of uric acid production and metabolism, there are two types of commonly used uric acid-lowering drugs, one can inhibit the production of uric acid, and the representative drug is allopurinol; One is the one that can promote the excretion of uric acid, and the other is probiotics, which is Lactobacillus grigai.

Simple high uric acid does not need to take medicine, generally through the control of diet, intestinal probiotics are the second largest way of uric acid metabolism, supplementing probiotics with uric acid-lowering effect is a good choice Such as the domestic patented strain Lactobacillus grigi has many effects; If uric acid control is needed during a gout attack, commonly used drugs that inhibit uric acid synthesis are febuxostat and allopurinol, and benzbromarone, which excretes acid.

People with high uric acid may take drugs that promote uric acid excretion or drugs that inhibit uric acid production. Hyperuricemia is closely related to the poor prognosis of blood vessels, heart, and kidneys, and is also the pathophysiological basis of gout. Hyperuricemia can choose drugs that inhibit uric acid synthesis, such as allopurinol or even febuxostat, which are drugs that inhibit uric acid synthesis.

Of course, the specific type and dosage should be reasonably selected under the guidance of the doctor to ensure efficacy and safety.

At the same time, nearly 90% of patients with high uric acid have abnormal uric acid excretion, and drugs that promote uric acid excretion can also be selected, including Ligalizian, which should drink more water after eating, which can help the excretion of uric acid. Although hyperuricemia requires medication to help, it is also important to avoid eating a high-purine diet, such as animal offal, various soups, such as fruit soup, vegetable soup, chicken soup, duck soup, hot pot soup, and avoid eating all kinds of seafood. For high uric acid, the drugs that can be selected at present are febuxostat, allopurinol, benzbromarone, etc., as follows:

1. Febuxostat: Febuxostat and allopurinol are inhibitors of xanthine oxidase, but febuxostat is not recommended for patients with only hyperuricemia and ** wind;

2. Allopurinol: In the process of application, it is necessary to pay attention to the occurrence of rash, leukopenia, liver damage, etc., febuxostat and allopurinol are mainly used to inhibit the production of uric acid;

3. Benbromarone: It is mostly used for patients with reduced uric acid excretion, and the patient's uric acid excretion can be judged by 24-hour uric acid.

No matter which kind of uric acid-lowering drug is chosen, it is necessary to intervene in the lifestyle, reduce the intake of high-purine foods, such as animal offal, seafood and meat, mainly pork, beef, and mutton, and it is recommended that patients with hyperuricemia drink more water every day to help promote uric acid excretion.

The best medicine is baking soda. He can**. High uric acid.

Patients with high uric acid have a good effect on reducing uric acid by taking febuxostat tablets, benzbromarone capsules, compound sodium bicarbonate tablets and other drugs under the guidance of doctors, and the specific analysis is as follows:

1.Febuxostat tablets: After patients have high uric acid, they can usually take febuxostat tablets under the guidance of a doctor**, febuxostat tablets can effectively inhibit the production of uric acid, and the effect of reducing uric acid is generally better.

2.Benbromarone capsules: Benbromarone capsules are an anti-gout drug, which is often used for primary and secondary hyperuricemia, gout, gouty arthritis and other diseases. Patients with high uric acid can take benzbromarone capsules under the guidance of a doctor to promote uric acid excretion.

3.Compound sodium bicarbonate tablets: patients with high uric acid, can take compound sodium bicarbonate tablets under the guidance of a doctor**, compound sodium bicarbonate tablets can increase the pH value in the urine, is an acid salt formed by the neutralization of strong alkali and weak acid, which can usually speed up the dissolution and excretion of urine.

The best drugs for lowering uric acid are:

1. Drugs that alkalize urine. Such as sodium bicarbonate tablets, it can alkalize acidic uric acid well, so as to achieve the effect of reducing uric acid.

2. Drugs for uric acid excretion, such as benzbromarone and febuxostat, can reduce uric acid very well. However, febuxostat is currently the most used, because it has a good uric acid-lowering effect and is less effective for liver and kidney function.

3. Uric acid-lowering drugs, such as allopurinol, can make uric acid drop and excreted from the body, thereby reducing uric acid.

4. Colchicine, take one tablet twice a day to lower uric acid**.

There are two main types of uric acid-lowering drugs commonly used in clinical practice: inhibiting uric acid production and promoting uric acid excretion.

1. Inhibition of uric acid production

1. Allopurinol: This drug is suitable for patients with excessive uric acid production in the body or unsuitable for uric acid excretion drugs, but patients with renal insufficiency need to be used as appropriate. A small number of patients may have adverse reactions such as abdominal pain, diarrhea, rash, and fever after use;

2. Febuxostat: suitable for patients with mild to moderate renal insufficiency, and with caution for patients with severe renal insufficiency. It may cause adverse reactions such as abnormal liver function and diarrhea.

2. Promote uric acid excretion

1. Benbromarone: This drug is not suitable for patients with uric acid kidney stones. Adverse reactions include gastrointestinal symptoms, rash, renal colic, granulocytopenia, etc.;

2. Probenecid: Sulfonamide allergy is prohibited.

3. Urate-lowering probiotics;

Lactobacillus gasseri: At present, there have been experiments to prove that Lactobacillus gasseri has the function of lowering uric acid, and probiotics basically have no effect, and the effect of lowering uric acid is also very good. There are also detailed descriptions in it.

The main drugs that lower uric acid are allopurinol, febuxostat, and benzbromarone. The efficacy of these three drugs is different, allopurinol and febuxostat are drugs that inhibit uric acid production; Benbromarone is a drug that promotes the excretion of uric acid. The specific analysis is as follows:

1.Allopurinol: It can inhibit xanthine oxidase, reduce uric acid synthesis, and reduce the concentration of uric acid in the blood. However, patients with elevated creatinine cannot take allopurinol, and people who are allergic to allopurinol cannot take it. Allopurinol is highly effective.

2.Febuxostat: It is a xanthine oxidase inhibitor, which is suitable for patients with hyperuricemia with gout symptoms, and its uric acid-lowering effect is relatively good and relatively safer.

However, patients need to pay attention to the dosage and recheck the liver function on time to avoid inducing gout. For patients with coronary artery disease, febuxostat should be used with caution.

3.Benbromarone: can effectively inhibit the production of uric acid, has a dual effect on reducing the concentration of blood uric acid, and can be used for primary hyperuricemia. It should be noted that patients with kidney stones should not take benzbromarone.

Commonly used drugs that inhibit the synthesis of uric acid are febuxostat and allopurinol, and the drugs that excrete acid are benzbromarone, and it is not recommended to use drugs with high uric acid alone Probiotics with uric acid-lowering effect such as Lactobacillus gasseri can be supplemented with probiotics with uric acid-lowering effect, which is a domestic high-quality probiotic, and probiotics decompose excess uric acid and purines in the intestine to reduce the synthesis of uric acid.