Why is albuterol aerosol resistant if used too much?

Pharmacological effects] Albuterol is a highly selective 2-receptor agonist, and its excitatory effect on the heart is smaller than that of isoproterenol when inhaled. After a certain dose of isoproterenol reaches a certain dose, the maximum respiratory volume in the first second, which represents the degree of bronchiectasis, no longer increases, while the heart rate still continues to rise with the increase in doseAlbuterol dilates the bronchial effect, and the maximum respiratory volume and heart rate increase effect in the first second increase in parallel with the dose, but the acceleration of the former is faster than that of the latter, and its bronchial dilation effect is about eight times that of the heart rate effect.

However, long-term use can form drug resistance, which not only reduces the efficacy, but also has the risk of aggravating asthma, so for those who regularly use this product, inhaled or systemic corticosteroids should be used at the same time**. If the patient's symptoms are severe and need to inhale this product multiple times a day, the maximum expiratory flow rate should be monitored at the same time, and the patient should go to the hospital for treatment, and ask a professional physician for guidance** and medication.

Albuterol is a potent bronchodilator that targets 2-receptors attached to the bronchial mucosa and is a highly selective 2-receptor agonist. In fact, regular doses of albuterol are not associated with adverse effects such as pallor, headache, palpitations, arrhythmias, increased blood pressure, and vomiting caused by theophylline. Are you taking too much medicine?

Or you may be uncomfortable with this medicine. It is recommended that you consult a doctor and find an alternative**.

Nausea and heart palpitations are all ***. Generally, the dose is reduced and recovered, and the drug should be discontinued in severe cases.

Long-term drug use can lead to drug resistance, which not only reduces efficacy, but may also worsen asthma.

I myself also have allergic asthma I have a history of nearly 10 years I got it at a very young age and was sent to the hospital for rescue several times I used adrenal hormones Vantolin spray There will be no hormones*** The relief effect is immediate But it is recommended that you have a humidifier at home and eat more grapes Take loratadine or aminophylline Vitamin C supplementation will be very effective Of course, I also have to do low-intensity aerobic exercise to expand my lung capacity I insisted on swimming and moved out of the original city I haven't committed it for more than a year You can see Chinese medicine and take Chinese medicine to stay away from allergens (It's better to go to the hospital to test for allergens).

Do you have allergic asthma or other causes of your asthma? Any kind of antiasthmatic medicine is not standardized or after a long time, it will produce some undesirable situations, it is recommended that you go to a regular hospital for further examination to determine the best plan!

Rarely, muscle tremors, peripheral vasodilation, and compensatory rapid heart rate, headache, restlessness, and anaphylaxis may be seen.

Early manifestations of overdose poisoning: chest pain, dizziness, persistent and severe headache, severe hypertension, persistent nausea, vomiting, persistent palpitations, emotional irritability, etc. Repeated overdose can occasionally cause bronchospasm, and if it occurs, it should be stopped immediately and the ** regimen should be adjusted under the guidance of a doctor.

1 Patients with hypertension, coronary heart disease, diabetes, hyperthyroidism, etc. should be used with caution; 2 Long-term use can form drug resistance, not only reduces the efficacy, but also has the risk of aggravating asthma, so for those who regularly use this product, inhaled or systemic corticosteroids should be used at the same time**. If the patient's symptoms are severe and need to inhale this product multiple times a day, the maximum expiratory flow rate should be monitored at the same time, and the patient should go to the hospital for treatment, and ask a professional physician for guidance** and medication. 3. When using it for the first time or after using it for more than a week, it should be sprayed into the air first; If the spray does not work, please confirm whether it is used correctly or check whether the spray hole is blocked; 4 The liquid medicine in the container of this product is filled with gaseous substances at room temperature after low temperature pressurization, please keep this product away from heating objects such as stoves, heaters, electric heaters, etc., to avoid the high-pressure liquid in the bottle from being heated**, the plastic bottle sleeve of this product is used as a protection when danger may occur, and it is forbidden to dial it down at any time; This strain is a pressurized container, it is strictly forbidden to impact, even if the medicine is used up, it should be avoided; 5. This product should be stored in a cool place, that is, the temperature is below 20, but refrigeration and freezing are not allowed; 6 Keep this medicine out of the reach of children.

1 For those who use other adrenergic receptor agonists at the same time, their effects can be increased, and adverse reactions may also be aggravated; 2 When combined with theophylline, it can increase the effect of relaxing bronchial smooth muscle, and may also increase adverse reactions.

Problem Analysis:

Hello, this drug belongs to the cough and asthma drugs, should be used reasonably according to the doctor's instructions, excessive use may cause transient hypertension, headache, palpitation and discomfort symptoms. It is necessary to maintain a good attitude, use medicine rationally, rest more, pay attention to cold protection and warmth, and seek medical treatment if necessary.

Suggestions: Maintain a good attitude and eating habits, follow the doctor's instructions for reasonable diagnosis, and have regular check-ups. Good luck soon**!