What are the symptoms of lymphocytic leukemia?

Patients often present with fever, cough, sputum production, and bleeding, such as mucosal bleeding, petechiae, or bleeding from the oral gums.

When it is not severe: it is easy to feel tired, have little energy, have no appetite for any food, and even become thinner. In severe cases: **It will be very itchy, dizzy, a little wheezing, and bones will be painful.

Generally, the most obvious symptoms are that there may be some fever, sometimes some itching, and often feel nausea and vomiting, and also feel that the body has no strength, appetite will also be reduced, and frequent abdominal pain. Shortness of breath and tightness in the chest.

There are two types of lymphocytic leukemia: acute and chronic. Acute lymphoblastic leukemia is a hematologic malignancy caused by the indefinite proliferation of undifferentiated or poorly differentiated lymphocytes in hematopoietic tissues, particularly the bone marrow, spleen, and lymph nodes.

Classification of acute lymphoblastic leukemia.

By cell size (Fab, Chinese standard).

L1 protolyphic cells are mainly small cells and large cells.

L2 primary lymph cells are dominated by large cells.

L3 cells are predominant, cytoplasmic and dark blue, and the hollow vacuoles are honeycomb-shaped, which is called Burkitt type.

By cell phenotype (WHO criteria).

Precursor B--All: cell morphology such as L1 or L2, immunophenotype of lineage B: CD19, CD22, CD79A, CD10 positive, TDT+. 80% 85% of all.

Precursor T-ALL: cell morphology such as L1 or L2, immunophenotype is T-line: CD3, CD7, CD4, CD8 positive, TDT can also be positive, accounting for 15% of ALL.

The World Health Organization (WHO) classifies L3 (Burkitt type) as a mature B-cell tumor.

Although there are some differences in the clinical manifestations of various types of ALL, they are basically the same. They are described as follows:

1. The general symptoms are generally relatively slow except for the acute onset of T-ALL. In the early stages, it usually manifests as fatigue, weakness or irritability, loss of appetite, and occasional vomiting. There are also symptoms that initially manifest as a viral upper respiratory tract infection, or a rash that develops followed by weakness.

Bone and joint pain are also common symptoms.

2. Progressive pallor appears in the early stage of anemia, which is more obvious to ** and lip mucosa, and with the aggravation of anemia, symptoms such as shortness of breath and weakness after activity can appear. Due to the acute onset of t-all, anemia is not severe at the time of diagnosis.

3. More than half of the fever has fever and indefinite heat type. The cause of fever is mainly secondary infection.

4. Bleeding about half of the patients have epistaxis, gingival bleeding and **purpura or petechiae, ecchymosis, and occasionally intracranial hemorrhage. In addition to the abnormal quality and quantity of platelets, the cause of bleeding can also be due to the infiltrative damage of leukemia cells to the blood vessel wall, which increases permeability. Occasionally, DIC can occur in T-ALL, possibly due to the release of substances such as thrombin and kinase from primitive T-ALL cells.

5. The symptoms caused by the infiltration of leukemia cells in the organs are about 2 3 The children have mild or moderate enlargement of the spleen, and the liver is mostly mildly enlarged and soft. Lymphadenopathy is mostly mild and confined to the neck, submandibular area, armpits, groin, etc.

There are two types of lymphocytic leukemia: the first is acute lymphoblastic leukemia; The second is chronic lymphocytic leukemia. Symptoms of acute lymphoblastic leukemia are:

1. Anemia. Patients often have moderate or higher anemia, which may be accompanied by symptoms such as dizziness, fatigue, paleness, palpitation, chest tightness, etc. 2. Infection.

Most patients will have an elevated body temperature, sometimes similar to a cold, but also high fever, common infections such as pneumonia, stomatitis, etc. 3. Symptoms of bleeding. The patient presented with nasal mucosal hemorrhage, **mucosal hemorrhage spots, ecchymosis, etc.

4. Swollen lymph nodes in the liver and spleen. Generally, patients will have swollen lymph nodes in the neck, armpits, groin and other parts, and will also have liver and spleen enlargement. Symptoms of chronic lymphocytic leukemia are:

Lymphadenopathy in the liver and spleen, as well as symptoms of hypermetabolism such as fatigue, fever, and weight loss.

Clinical presentation. In the early stages, he is often asymptomatic and often presents with the discovery of ** lymphadenopathy or unexplained elevated absolute lymphocyte values. Patients have nonspecific manifestations such as mild fatigue and fatigue, and once they enter the advanced stage, in addition to generalized lymph node and spleen enlargement, they may present with weight loss, recurrent infections, bleeding, and anemia.

Due to the older age of the susceptible population, patients often have exacerbation due to other underlying chronic conditions such as chronic lung disease, cerebrovascular disease, cardiovascular disease, etc.

1.Swollen lymph nodes.

80% of patients have ** lymphadenopathy, which can be generalized, mild to moderate swelling, occasionally obvious swelling, not adherent, often involving the neck, supraclaviclacle, armpit and groin.

2.Hepatosplenomegaly.

Half of patients have mild to moderate splenomegaly with abdominal fullness, late pelvic infarction or splenic rupture, and hepatomegaly is rare.

3.Anemia and bleeding.

Anemia or thrombocytopenia may occur as the disease progresses, most often due to bone marrow infiltration of leukocyte cells or the production of autoantibodies, and occasionally hypersplenism due to splenomegaly.

4.Extranodal infiltration.

Lymphocytes can infiltrate the conjunctiva, lungs, pleura, gastrointestinal tract, bones, nervous system, kidneys, etc.

5.Complication.

Immunodeficiency and manifestations of immune disorders, such as infections with conditionally pathogenic pathogens, autoimmune diseases, and secondary tumors.

1. Fever and infection: More than half of the patients are diagnosed with fever, which can be low-grade fever or high-grade fever. Regardless of whether the fever is before or during the epidemic, I mostly mean that it is co-infected.

Infections can occur anywhere in the body, but angina and stomatitis are the most common, upper respiratory tract and lung infections, perianitis, paraanal abscess, and gastroenteritis are more common, and leukemia is one of the leading causes of death. Some acute leukemia fever may have no obvious foci of infection (especially neutrophil<

l), but infection cannot be ruled out; Conversely, the body temperature of patients who automatically subside after the start of chemotherapy indicates that the fever is related to the leukemia itself (tumor fever). Of course, there is no shortage of clinical cases where tumor fever and infection coexist.

2. Anemia: Many people confuse anemia with leukemia, so the best time for treatment is delayed. Acute lymphoblastic leukemia often develops early and progressively worsens.

Manifestations include pallor, weakness, dizziness, palpitations, anorexia, and edema. The degree of anemia in patients is often disproportionate to the amount of bleeding.

3. Bleeding: About half of the cases have different degrees of bleeding. Bleeding usually occurs slightly later than anemia, but it often prompts the patient to seek medical attention and have a hemogram done.

Common bleeding includes bleeding spots, purple spots, epistaxis, bleeding from the gums and oral mucosa, increased menstruation, etc.; In severe cases, hematuria, gastrointestinal bleeding (hematemesis, hematochezia), retinal hemorrhage can cause visual impairment, and even intracranial hemorrhage, which is often life-threatening.

Disease analysis: 1. General symptoms The onset is insidious, the progress is slow, and the tumor itself can cause symptoms such as fatigue, fatigue, and emaciation. 2. Infection Various infections occur due to immunodeficiency caused by abnormal immunity, and the most common infections are respiratory, gastrointestinal, urinary, sepsis, etc.

3. Hepatosplenic lymphadenopathy Superficial lymphadenopathy is the most common sign of chronic lymphadenopathy, which can change from small to large with the progression of the disease, from small to large, from local to systemic. Enlarged lymph nodes have the characteristics of smooth surface, no adhesions, movable, hard texture, and no tenderness. Abdominal lymph nodes can cause abdominal pain, and mediastinal lymphadenopathy can cause coughing, hoarseness, and difficulty breathing.

The liver is mostly mildly enlarged, and splenomegaly is not as pronounced as the slow granules. Fourth, ** damage About 10% of patients can have ** lesions, which are scattered red or purplish-red maculopapular rashes, which are caused by the infiltration of leukemia cells. Non-invasive lesions such as pruritus, pigmentation, erythema, exfoliative dermatitis, and herpes zoster may also be present.

Suggestions: Hello, the ** program of chronic lymphocytic leukemia is closely related to the patient's condition and individual situation. The symptoms that usually manifest in the early stage are not obvious, and the early ** in order to increase the ** rate.

If the patient is receiving chemotherapy, it is recommended that the patient cooperate with the combination of tumor biological immunity to effectively reduce the toxicity caused by chemotherapy and achieve the hope of survival with tumor.

Chronic leukemia is generally insidious in onset, slow progression, there will be fatigue, fatigue, emaciation and other symptoms that can be caused by the tumor itself, which is to go to the hospital in time, chronic leukemia is generally found in the blood test of other diseases, it can be seen that the physical examination is still very necessary, (cancerous heart Qi Feng) to give you more enlightenment!

Condition analysis: Hello, the early symptoms of leukemia, the first symptom is anemia, the main manifestation is paleSuggestions: weakness, weakness, and excessive sweating.

There is shortness of breath and rapid heartbeat, but it is necessary to rule out anemia caused by blood loss such as hemorrhoids, gastrointestinal bleeding, excessive menstrual bleeding, and nutritional deficiency anemia caused by picky eating. Most patients will have fever, mainly irregular fever, and will have symptoms such as nasal congestion, runny nose, and cough. Superficial lymph nodes may be enlarged for unknown cause**, and bleeding is common.

The main symptoms of early leukemia are as described above. If the patient's condition is similar to the above, it is necessary to go to the hospital immediately for examination, and take some drugs to improve immunity and anti-cancer, such as ginsenoside rh2 (life protecting) with about the content of anti-cancer substances in traditional Chinese medicine, so as to control cancer cells, inhibit the expression of oncogenes, and effectively prevent and inhibit cancer cells. Good luck B3

Hello. In the early stage of chronic leukemia, there may be fatigue and fatigue, gradual dizziness, palpitations, shortness of breath, weight loss, low-grade fever, night sweats, purpura, itching, bone pain, often easy infection, etc., and there will also be lymphadenopathy. Such as aplastic anemia, thrombocytopenic purpura, bone marrow dysfunction syndrome, pure red aplastic aplastic and so on.

It can be seen that (Qi Feng's acute cancerous heart pathway) is in remission.