What causes Parkinsonism?

Parkinsonism can be caused by:

Clause. 1. It is a lesion of the central nervous system, because clinical studies have found that in the central nervous system of patients with Parkinson's disease, the content of excitatory neurotransmitters and inhibitory neurotransmitters in the black striatum and white matter mosquitoes is problematic, and the metabolism of neurotransmitters is also disordered, which is the main cause of Parkinsonism.

Clause. Second, it is a physiological factor, that is, with the increase of age, the function of cranial nerves will naturally decline, and the neurotransmitters and the content of neurotransmitters in the brain will decrease, resulting in cranial nerve dysfunction and Parkinsonism syndrome.

Clause. 3. It may be caused by life factors, such as poor living habits, spicy and greasy food, smoking, alcoholism, etc., which can also cause Parkinsonism.

In short, there are many reasons, we must take good care of our bodies, early detection, early **. Hope mine is helpful to you!

Parkinson's disease refers to a disease caused by various other causes, similar to Parkinson's disease, mainly due to hydrocephalus or cerebrovascular disease, traumatic brain injury, immune system disease.

In addition, it is also related to genetic factors, poisons, psychiatric drugs, depression, drug degeneration, infections, factors, oxidative stress and free radical formation, which can cause damage to nerve cells in the substantia nigra striata in the basal ganglia of the brain, affecting neurotransmitters, resulting in symptoms similar to Parkinson's disease, such as bradykinesia, muscle rigidity, resting tremor, etc.

Parkinsonism refers to the symptoms similar to Parkinson's disease such as resting tremor, bradykinesia, and muscle rigidity caused by some **, and the common causes of Parkinsonism include cerebrovascular disease, degeneration, infection, poisoning, drugs, etc. Some factors that cause parkinsonism are reversible, such as an overdose of antipsychotics, antidepressants, or long-term use, which can cause parkinsonism, and the symptoms will gradually disappear after stopping the drug. However, most of the Parkinson's syndrome, such as cerebrovascular disease, degeneration, infection, poisoning, etc., are irreversible and extremely difficult.

Unlike Parkinson's disease, levodopa does not respond well to Parkinsonism. Sometimes primary parkinsonism and parkinsonism can be difficult to distinguish between and can be distinguished by careful history.

There are three of Parkinson's's **:

1. Age: Age is the most important factor in Parkinson's, the incidence of Parkinson's disease over 65 years old is 4%-5% when it is over 80 years old, so Parkinson's is age-related, that is, with the increase of age, the incidence of Parkinson's disease is gradually increasing, which depends on the increasing age, the nerve cells in the substantia nigra of the midbrain are gradually decreasing, and normal people are also decreasing, so after a certain age, it is reduced to a threshold, such as Parkinson's disease when it reaches 50%. Therefore, age is one of the most basic and major factors in Parkinson's disease, and there is a saying that as long as people live to a large enough age, everyone can get Parkinson's;

2. Environmental factors: there are many reasons for environmental factors, such as pesticides, the United States in the 60s farmers use pesticides, the number of Parkinson's disease will increase, studies have shown that people who drink well water are easy to get Parkinson's, because the well water used to have pesticides, in fact, it is still a problem of pesticides, such as pesticides, especially in rural areas, can lead to an increase in the incidence of Parkinson's disease, and some heavy metals such as manganese, air pollution of lead can increase the incidence of Parkinson's disease, it is clear that welders, A professional welder has a higher chance of getting Parkinson's because the smoke emitted by the welder after spot welding has manganese metal, and environmental factors have these factors;

There are two major categories of Parkinson's syndrome, the first category is the main most obvious, such as the elderly after multiple cerebrovascular diseases, as well as poisoning and infection, taking specific drugs. Common drugs such as antihypertensive drugs may cause this condition, and some psychotropic drugs may cause Parkinsonism, which may have a certain reason. There is also a degenerative disease, such as a very rapid progression, such as multiple system atrophy, which may manifest as parkinsonism, some progressive supranuclear palsy, or a parkinson-like change.

This is a neurodegenerative disease, and the cause of it may be related to the genetic environment, but the cause is not particularly clear.

Parkinson's disease is a kind of striatal substantia nigra system that occurs in the nervous system, the striatum nigra nigra, which is related to the coordination of movement and movement, such a nervous system circuit This is the traditional understanding, it is mainly dopaminergic neurons, the dopaminergic neurons of this circuit are subject to some reason, so far we can not understand the reason, for example, there may be environmental factors, there may be poisoning, there may be a genetic background, there may be long-term stress pressure, It is the intrinsic causes that work through the extrinsic causes, and it may be a complex mechanism that causes Parkinson's disease.

The causes of Parkinson's disease are generally related to genetics, diffuse brain damage caused by poisoning, adverse reactions to taking antipsychotic drugs, viral infections, cerebral arteriosclerosis caused by aging of the nervous system, cerebrovascular diseases such as multiple cerebral infarctions, traumatic brain injury, intracranial space-occupying lesions, parathyroid dysfunction and other factors.

Parkinson's disease is commonly known as parkinsonism, it is mainly manifested by sluggish movements, and there is also a professional term called resting tremor, that is, when sitting there without moving, you can also see that the patient's limbs, hands and feet are shaking, and there is also a muscle stiffness, which is the third characteristic, and the fourth characteristic is likely to appear in the special posture of the limbs, because muscle stiffness includes the limbs, including the muscle stiffness of the trunk, and the movements are like apes, so the main manifestations are these aspects. It generally occurs in middle-aged and elderly people, and is a neurodegenerative lesion, the reason for its occurrence is because there is a part of the midbrain in the brain, which has a place called the substantia nigra, and the neurons in the substantia nigra have undergone degeneration and necrosis, which has led to the reduction of dopamine substances, resulting in corresponding manifestations.

In some patients with Parkinson's disease, due to aging and aging of the nervous system, dopaminergic neurons in the substantia nigra begin to degenerate, and the number of dopamine neurons in the substantia nigra gradually decreases. Genetic factors, environmental factors, ageing, oxidative stress, etc., may be involved in the degeneration process of Parkinson's dopaminergic neurons, and the incidence and prevalence of golden's disease increase with age, and the incidence is more than 60 years old, which suggests that aging is related to the pathogenesis.

This may be related to genetics.

At present, Parkinson's disease is still a disease whose cause is not very clear, and it is also a disease with many types, the main types are primary Parkinson's disease, secondary Parkinson's disease and hereditary Parkinson's disease.

1. Primary Parkinson's disease. It is generally believed that primary Parkinson's disease is a degeneration of nerve cells, and the main lesions are in the substantia nigra and striatum. There is a kind of nerve cell called substantia nigra cells, and the degeneration of nerve cells here refers to the gradual decrease in the number of substantia nigra cells, the gradual decline and loss of function, resulting in a decrease in dopamine in the brain, thus causing symptoms of Parkinson's disease.

2. Secondary Parkinson's disease. Secondary Parkinson's disease is mostly caused by infection, poisoning, drugs, trauma, etc.

1) Infection: encephalitis, lentiviral infection, etc. may cause secondary Parkinson's disease.

2) Poisoning: Poisoning caused by exposure to MPTP, carbon monoxide, manganese, mercury, carbon disulfide, methanol, ethanol and other poisons may also lead to secondary Parkinson's disease.

3) Drugs: Neuroleptics for psychiatric diseases such as phenothiazines and butyrylbenzene are the most common pathogenic drugs that may cause Parkinson's disease.

4) Trauma: such as traumatic brain injury, boxing encephalopathy, etc., may also cause secondary Parkinson's disease.

In addition, vascular diseases such as cerebral arteriosclerosis, multiple cerebral infarction, and other diseases such as thyroid dysfunction and positive pressure hydrocephalus may also cause secondary Parkinson's disease.

3. Hereditary Parkinson's disease. According to the results of animal experiments and epidemiology, it is also believed that Parkinson's disease has a certain relationship and connection with heredity. It can be seen in diseases such as Wilson's disease and dopa-responsive dystonia.

In short, the above main introduction to you is the cause of Parkinson's disease, since you have introduced to you what are the causes of the disease, this requires everyone to know more, especially the middle-aged and elderly need to know more, so as to do a good job in the prevention of Parkinson's disease.

Most patients with Parkinson's disease develop between the ages of 50 and 60 years, and with age, the function of nerve cells weakens and the secretion of dopamine decreases, resulting in an increased incidence rate; Parkinsonism is also caused by environmental and genetic factors. Parkinson's disease, also known as parkinsonism, is a chronic progressive neurodegenerative disease with resting tremor and muscle rigidity and posture and gait abnormalities as the main manifestations, and the pathological basis of Parkinson's disease is because the dopamine content in the brain is reduced, so supplementing the content of dopamine, enhancing the release of dopamine and promoting the utilization of dopamine is the best way to do Parkinson's.

Genetic factors. It is thought that 10% of patients have a family history, and the vast majority of patients are sporadic. Segments and.

Environmental factors. Industrial or agricultural toxins in the environment that are similar to the neurotropic 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP) molecular structure, such as certain pesticides, herbicides, rotenone, etc., may be one of the most important causes of Parkinson's disease.

Aging of the nervous system.

Some data show that after the age of 30, with age, substantia nigra dopaminergic neurons begin to show degeneration, but not all of them lead to Parkinson's disease, aging is the most important factor in the occurrence of Parkinson's disease.

Multi-factor interactions.

With the exception of a small number of people with familial Parkinson's disease, genetic susceptibility increases the likelihood of developing the disease, but it does not necessarily lead to the disease.

It is due to the combined effect of environmental factors, aging of the nervous system and other factors that will lead to the onset of the disease.

Parkinson's is a common disease in the elderly, the early symptoms are common with tremors, and the consequences are more serious, which can lead to the patient's disability and inability to take care of himself, ** It is not clear at present, and the common factors include: 1. Genetic factors: the patient has a susceptible constitution; 2. Stuffy hands and dry environmental factors; 3. Biochemical factors; 4. Drug-induced factors:

It is often inappropriate to use antolamine drugs, such as morpholine, metoclopramide and other gastrointestinal drugs, sedative drugs, and antidepressants; 5. Physical and chemical factors; 6. Pesticide poisoning.

It is caused by the degeneration of the striatum nigra in the brain and a significant decrease in the amount of dopamine in the brain. There are also drugs, trauma or infections.

That's a complicated question! Let me tell you, many people who suffer from this disease nowadays are usually elderly! It should be based on a mutation or a neurological problem! If there is no way to **! The causes of blight disease are complex! You try it!

Many are caused by trauma.

1. Environmental elements. Environmental factors are the cause of Parkinson's disease in the elderly, and the key to prevention is to start from the natural environment. More than a decade ago, biologists discovered that a compound, MPTP, can cause typical Parkinson's disease in humans and their small animals.

Not only are the symptoms completely similar, but the pathology of Parkinson's disease caused by this compound is also very similar to that of human Parkinson's disease from the changes in the pathological structure and medical record. 2. Cerebral arteriosclerosis: Parkinsonism can occur when multiple lacunar cerebral infarctions occur in the spinal cord and basal ganglia caused by cerebral arteriosclerosis, which affects the substantia nigra dopamine striatal channel.

However, most of these patients have pseudobulbar palsy, hyperreflexia, and positive pathology, and often have significant Parkinson's disease, which is also the cause of geriatric Parkinsonism. 3. Genetic elements. Parkinson's disease can be inherited genetically, so genetic elements are also the cause of elderly Parkinson's disease, but the proportion of genetic elements is not very large.

I firmly believe that with the in-depth analysis of genes, we will have a deeper grasp of the expression of genes and the role of proteins, and we are still looking forward to the treatment of medicines, the treatment of the causes of diseases, and the treatment of genes. Genetic elements account for about 10% of the chance of Parkinson's disease.

Parkinsonism can usually have the following**

1.Aging is one of the most common causes. The prevalence of PD varies with age, and glutathione peroxidase and catalase decrease during aging and PD. With age, monoamine oxidase increases, iron, copper, calcium aggregates, and melanin aggregates.

Incidence increases with age.

2.Genetic factors, genetic mutations can lead to degeneration and death of neurons, and if the striatum nigra is affected, Parkinsonism will occur.

3..Trauma, traumatic brain injury can also lead to Parkinsonism.

4.Cerebrovascular disease, poisoning, encephalitis, drug abuse, etc. are also the most important aspects of Parkinsonism.

5.Environmental toxicants: Manganese poisoning, carbon monoxide poisoning, phenothiazine, and butyrylbenzene have long been noted to produce PD symptoms.

6.There are also neurodegenerative diseases, such as multiple system atrophy and corticobasal degeneration, that can also cause parkinsonism.