What are the Parkinson s medications? What are the commonly used drugs for Parkinson s?

There are six main categories of drugs commonly used in Parkinson's disease:

1. Levodopa preparations: including medopa, Xining, Dalingfu, etc., the first choice for elderly patients or patients with mental retardation, is the most basic and effective drug for Parkinson's disease, and has good efficacy for tremor, rigidity, and bradykinesia.

2. Dopamine receptor agonists: commonly used are pramipexole hydrochloride tablets, piribedil sustained-release tablets, ropinirole hydrochloride tablets, etc., which are suitable for early-onset patients in the early stage of the course of the disease, and should be gradually increased from the smallest dose until satisfactory efficacy is obtained, and there is no ***.

3. Monoamine oxidase B inhibitors: the main drugs are selegiline hydrochloride tablets and rasagiline mesylate tablets, which are suitable for patients with early Parkinson's disease, and can also be used for patients with advanced Parkinson's disease, which has the effect of improving motor symptoms.

4. Catecholamine methyltransferase inhibitors: the main drugs are entacapone tablets and tolcapone tablets, and adding such drugs in the middle and late stages of the disease can improve the symptoms of patients.

5. Amantadine hydrochloride tablets: It can improve oligopoly, rigidity and tremor in patients with Parkinson's disease.

6. Anticholinergic drugs: such as trihexyphenidyl hydrochloride tablets, suitable for patients with obvious tremor.

What is the method of Parkinson's Chinese medicine ** (1) The prescription of Parkinson's ** method: 12 grams of gastrodia, sand ginseng, raw land, mulberry parasitic, and cocos, 18 grams of stone cassia, 20 grams of hook vine, ochre, nightshade, turtle version, 25 grams of raw keel, raw oyster, 10 grams of red peony, asparagus, hyssop, eucommia, bupleurum, and gardenia. How to use:

The decoction is divided into 3 doses, 1 dose per day. Interaction: If the liver fire is prevalent and the anxiety is disturbing, add gentian grass and prunella vulgaris; If there is more phlegm, add bamboo drain and Tianzhu yellow to clear heat and dissolve phlegm; , kidney yin deficiency, deficiency and heat disturbance, dizziness and tinnitus, plus Zhimu, cork, danpi; For palpitations and insomnia, add fried sour jujube kernels, cypress kernels, and purple salvia to nourish qi and nourish blood, and calm the heart and calm the nerves; Shaking does not stop, add zombie silkworms, whole insects, and improve the hand of extinguishing wind and stopping menstruation.

1. Atropine drugs. There are many kinds of anticholinergic drugs, generally including atropine, scopolamine, etc., these drugs have the effect and effect of inhibiting the activity of acetylcholine, and can effectively control the adverse reactions of dopamine in the brain, so as to adjust the immune function of patients.

2. Xi Ning. Xining is a compound levodopa, which is a complex of levodopa and the extracerebral decarboxylase inhibitor carbidopa, and is a controlled-release tablet dopamine replacement drug with a polymer matrix. This dopamine replacement drug can directly supplement the deficiency of dopamine in the brain, and at present, it is also one of the most effective drugs among all anti-Parkinsonian drugs.

3. Dopaminergic receptor agonist drugs. As a new type of clinical drug, dopaminergic agonist drugs can directly act on dopamine receptors, so as to help patients play a controlling and leading effect, adhere to the use of this drug, can effectively improve the symptoms of Parkinson's disease, delay the application of levodopa, and will also play a certain protective role in the nerves.

At present, there are many studies on Parkinson's disease in Parkinson's disease, and there are few studies on other types of Parkinsonism. People with Parkinson's disease need to take the medication for life once they take it; Early stages of decompensation should be non-levodopa if possible.

drugs, with poor efficacy, and then levodopa; The drug should be added at a small dose to achieve the effect and maintain the current minimum dose. The following is a brief description of the main drugs for Parkinson's disease.

Dopamine replacement**.

Generally, a combination of levodopa plus decarboxylase inhibitors is used, and levodopa is the most effective drug for the symptomatic treatment of Parkinson's disease.

Dopamine receptor agonists (DA).

DA is a class of synthetic drugs, commonly used such as bromocriptine.

Pegolite, piribedil sustained-release tablets, pramipexole, etc.

Monoamine oxidase.

B inhibitors. It is mainly used in the early stages of Parkinson's disease as a single agent or in combination**, which may have neuroprotective effects, and commonly used drugs include selegiline.

Rasagiline and safinamide.

Anticholinergics.

It helps to maintain the balance of neurotransmitters in the striatum, and is mainly used in patients with mild disease in the early stage, and has a good effect on tremor but poor on muscle rigidity and bradykinesia. Trihexyphenidyl is the most commonly used anticholinergic.

Amantadine. It is mainly used in early stage patients. It is more effective than tremor for oligoactivity and tonic symptoms.

Parkinson's disease, everyone should have heard, from a professional point of view, it is a neurodegenerative disease, in the early stage there will be tremors of limbs or other body organs, slow movement, crooked walking, speech and other symptoms, spirit and consciousness will also be a little different from ordinary people, such as insomnia, anxiety and depression, do not like to communicate with others, etc., if you encounter similar symptoms, quickly go to a big hospital for examination, if it is the early and middle stage of Parkinson's disease, it can be through drug + surgical medical means**, My grandmother downstairs was diagnosed with Parkinson's disease, and then installed an imported brain pacemaker, which is now almost no different from ordinary people.

1.Levodopa: commonly used drugs such as dopaserazine and oxyning;

2.Dopamine agonists: drugs such as pramipexole or tasuda;

3.Catechol-oxygen-methyltransferase inhibitors: like Codan;

4.Inhibitors of monoamine oxidase: selegiline and other drugs.

5.Surgery: Brain pacemaker surgery, such as the Medtronic rechargeable Active series, can be understated.

6.: Ask your doctor specifically.

At present, among the various methods of Parkinson's disease, the drug is still the most effective. In the history of drugs, it is necessary to pay attention to the following points: 1. Master the time of medication, no special ** is required in the early stage of the disease, patients should be encouraged to carry out moderate activities, such as physical exercise, and if the disease affects the patient's daily life and work ability, drugs can be carried out.

2. Adhere to the principle of fine water and long-term flow, not seeking full effect. 3. The principle of low and slow, that is, to maintain a low dose as much as possible, and increase the dose slowly. Fourth, emphasize individualization.

Drugs are the most important methods of Parkinson's disease, which can improve clinical symptoms by maintaining the balance of acetylcholine and dopamine in the striatum, and the common drugs are as follows: 1. Anticholinergics, which are effective for tremor and muscle rigidity, and have poor efficacy on bradykinesia. 2. Amantadine can promote the release of dopamine from nerve endings and reduce the reuptake of dopamine, which can improve the symptoms of tremor, muscle rigidity and bradykinesia in Parkinson's disease.

3. Dopamine substitution, which can supplement the deficiency of dopamine in the striatum nigra, is the most important method for Parkinson's disease. Since dopamine cannot penetrate the blood-brain barrier and is substituted**, the precursor levodopa is supplemented, and when levodopa enters the brain and is taken up by dopamine cyst neurons, it is decarboxylated and converted to dopamine. Levodopa improves all clinical symptoms in patients with Parkinson's disease, starting at low doses.

Parkinson's disease is also known as:"Tremor paralysis"It is a neurodegenerative disease that is common in middle-aged and elderly people, and usually occurs after the age of 60. It is mainly manifested by slow movements, tremors in the hands and feet or other parts of the body, and the body loses its flexibility and becomes stiff. Parkinson's disease is the fourth most common neurodegenerative disease among the elderly, affecting 1% of people aged 65; It occurs in people aged 40 years and can also occur in childhood or adolescence.

Aging, environmental factors, toxic exposure, genetics, etc. may all contribute to the occurrence of Parkinson's disease.

Parkinson's disease is caused in a part of the human brain called the midbrain. There, there is a group of nerve cells, called substantia nigra neurons, that synthesize a neurotransmitter called dopamine, and their nerve fibers project to other areas of the brain, such as the striatum, to regulate the brain's motor function. When these substantia nigra neurons degenerate and die to more than 80%, the neurotransmitter dopamine in the brain decreases to the point that it cannot maintain the normal function of the nervous system, dopamine secretion decreases, and the acetylcholine that is opposed to it is relatively increased, so the symptoms of Parkinson's disease such as:

Limb shaking, stiffness, limb weakness, etc. The isolated pacemaker is developed according to the principles of physics, and is mainly used for intractable neurological diseases such as epilepsy, Parkinson's, torsional spasm, hemiplegia, cerebral hemorrhage, dystonia, ataxia, etc.

When I was diagnosed with Parkinson's disease, my eldest brother was only 36 years old, which is still young compared to the majority of middle-aged and elderly people. From the day he was diagnosed, the eldest brother began to take medicine actively, but after three or five years, the effect of taking medicine was too reduced, and he seemed to wear shackles and plumb hammers on his feet when he walked, making it difficult to walk. I found Professor Zhao Chunsheng of the Department of Neurosurgery of Jiangsu Provincial People's Hospital, who is an authoritative expert who carried out the first case of brain pacemaker ** Parkinson's disease in Jiangsu and focused on motor dysfunction diseases such as brain pacemaker ** Parkinson's disease for 15 years.