What is osteosarcoma? What is the definition of osteosarcoma?

There are two kinds, the benign one is a tumor, which can be surgically removed! Malignancy is more troublesome, the popular saying is a bit scary, called bone cancer, this disease is more difficult to cure, the possibility of amputation is very high, and even if the amputation is done, there are very few who have survived 5 years!

Bone tumors are tumors that occur in bones or their surrounding tissues (blood vessels, nerves, bone marrow, etc.), and are formed by mutations and "neoplasia" and "cancer" of various cells in bone tissue. Bone tumors are divided into benign and malignant, benign bone tumors are easy to **, and malignant bone tumors develop rapidly, causing disability and mortality are high. Different from common tumors such as lung cancer, breast cancer, gastric cancer, colorectal cancer, etc., bone malignant tumors have a low incidence, accounting for 1% of all malignant tumors, but accounting for 15% of childhood malignant tumors.

Osteosarcoma is one of the most common malignant bone tumors and is very malignant. It is more common in adolescents and occurs at the metaphyseal end of the distal femur, proximal tibia, and proximal humerus. The main clinical manifestations are localized, persistent, and worsening at night, accompanied by a systemic cachexia state or limited movement of nearby joints.

Elevated epidermal temperature and venous distension may be found on the surface of the tumor. X-ray shows a distinct periosteal response and an aggressive development, with a Codman triangle or a "daylight" pattern. In addition to conventional**, it is recommended to inject Japanese WT1 tumor vaccine with antigen to enhance or induce the body's immune response to tumor cells, and use broad-spectrum WT antigen to prepare anti-tumor vaccine to promote T lymphocyte proliferation, activation and cytokine release.

Qingdao Hankang International Medical is responsible for the operation of Japan's WT1 tumor vaccine in China.

Question 1: What is the difference between osteosarcoma and bone cancer Osteosarcoma is a malignant tumor (cancer) with a relatively low degree of tissue cell differentiation, and it is also the most malignant bone cancer.

Question 2: Is osteosarcoma more serious than bone marrow cancer? Hello, according to your description, osteosarcoma is a malignant tumor that is prone to metastasis. It can be said to be very serious and requires aggressive chemotherapy, local radiation**, and cut-off if necessary**.

Question 3: What is bone cancer Oh my God, I don't know what kind of answer I see!!

There is no such thing as bone cancer, to be precise, it should be called osteosarcoma, and cancer refers to the malignant tumor of the epithelium!

Osteosarcoma, also known as osteosarcoma, is a malignant bone tumor that occurs more commonly in adolescents or children under the age of 20, and is the most common among pediatric bone malignancies, about 5% of pediatric tumors.

The prominent symptom of osteosarcoma is pain at the site of the tumor, which is caused by the erosion of tumor tissue and the dissolution of the bone cortex. The main manifestations are:1

Pain 2As the disease progresses, the mass may become swollen locally, and the lump may be palpable in the painful area of the limb with significant tenderness. If the lump grows rapidly, the lump can be found from the appearance of the leak.

The surface of the mass is warmed and superficial veins are exposed, and there may be varying degrees of tenderness on the surface of the mass and in nearby soft tissues. 3.Limp 4

At the time of diagnosis, the general condition is generally poor, with fever, malaise, weight loss, anemia, and even failure. In some cases, the tumor grows rapidly, and lung metastasis occurs at an early stage, resulting in a deterioration of the general condition. Pathological fractures at the site of the tumor make the symptoms more pronounced.

Osteosarcoma is still a disease with a high mortality rate among children and adolescents, but early detection and timely** have greatly improved the survival rate of the disease.

After the pathological diagnosis of osteosarcoma is confirmed, the early chemical or radioactive treatment begins**, and the removal of tumor tissue is an important step in osteosarcoma**. With the improvement of surgical oncology technology and the development of endoscopy research, limb preservation has shown a good prospect. Consolidation chemical or radioactivity** after resection of tumor tissue is important to control tumor metastasis and improve survival.

Osteosarcoma should be surgically surged. If possible, local wide excision can be done to preserve the limb. In addition, a biopsy should be performed prior to amputation.

Answer: B

item a, which is the manifestation of ankylosing Sun Wangdan's spondylitis; C, which is the manifestation of giant cell tumor of bone; Item E, which is a manifestation of chronic osteomyelitis.

Osteosarcoma is one of the most common malignant bone tumors, characterized by the direct formation of bone-like tissue by malignant tumor cells, also known as osteosarcoma. The disease is mostly affected by people aged 15-25 years. More than 70% of patients occur in the distal femur and proximal tibia.

Poor prognosis. As long as the symptoms of osteosarcoma are local pain, most of them are persistent, gradually aggravated, especially at night, accompanied by systemic cachexia, limited movement of nearby joints, local skin temperature increases, venous distension, and can easily lead to pathological fractures. Vasotremor may be felt or bruits heard. X-rays show a combination of neosporous bone formation and osteolytic destruction.

The treatment of osteosarcoma emphasizes early synthesis, with surgery and chemotherapy as the main treatment. If the diagnosis is clear and there are no lung metastases, high amputation or arthrodesis followed by chemotherapy should be performed. Patients with a single source of lung metastases may undergo amputation and resection of lung metastases at the same time.

Radiation** is not sensitive to osteosarcoma and is only used as an adjunct before and after surgery**, or when the tumor cannot be removed or lung metastasis.

About**:1Osteosarcoma is mainly comprehensive**, including surgery, chemotherapy, radiotherapy, etc.

2.Since the 70s, high-dose chemotherapy has been prevalent, applied before and after surgery, which has greatly improved the ** rate of osteosarcoma, and the five-year survival rate can exceed 50. 3.

Chemotherapy is commonly used in some of the following situations: (1) as an adjunct to surgery**; (2) Some parts cannot be operated on; (3) as late palliative reliever**; (4) The patient refuses surgery. Commonly used chemotherapy drugs advocate the combination of two or more drugs, and pay attention to ensure that the urine output is large and alkalinize the urine to reduce the toxic reaction of the kidneys.

Efficacy evaluation 1**: After a combination of surgery and chemotherapy**, more than two years of tumor-free survival.

2.Near-healing: After chemotherapy and amputation, no recent metastases to the lungs or other places have been found.

3.Good**After chemotherapy, the tumor has shrunk significantly and the symptoms have been reduced.

**The principle is still a combination of surgery and chemotherapy**. But the prognosis is poor.

Limb salvage for osteosarcoma** is still difficult! High-dose chemotherapy can be tried on a trial basis, but the effect is not as good as the "chemotherapy-surgery-rechemotherapy" comprehensive ** program, and if there are metastases, they can also be surgically resected.