Is IgA nephropathy serious and what is IgA nephropathy?

IgA nephropathy is the most common primary glomerular disease, which refers to primary glomerulopathy in which IgA or IgA deposition is predominantly in the mesangial area of the glomerulus, with or without deposition of other immunoglobulins in the mesangial area.

IgA nephropathy is a common primary glomerular disease, this condition is difficult to complete if it is said to be **, but it can be maintained and controlled by drugs, if the patient is well controlled, there is generally no problem, it is recommended that you usually pay attention to your diet, to be light, low-salt and low-fat diet, and then actively seek medical treatment.

Severe hyperplasia, glomerulosclerosis, crescent formation, capillary wall damage, interstitial fibrosis, and vascular compromise are indications for a poor prognosis of IgA nephropathy. The location of IgA precipitation is also related to the prognosis, and patients with IgA precipitation in the glomerular capillary wall have more pathological changes and worse prognosis than those with IgA precipitation in the mesangial area alone. Patients with fibronexin (FN) precipitation have a poor prognosis.

However, the rate of renal function decline is inconsistent in most patients.

LGA nephropathy is the most common primary glomerular disease, which refers to primary glomerulopathy in which IgA or IgA deposition is predominantly in the mesangial area of the glomerulus, with or without deposition of other immunoglobulins in the mesangial area of the glomerulus. The bed manifests as reversible gross hematuria or microscopic hematuria, which may be accompanied by varying degrees of proteinuria, and some patients may have severe hypertension or renal insufficiency.

IgA nephropathy usually refers to primary diffuse mesangial IgA nephropathy, IgA nephropathy is a group of diseases with a variety of clinical syndromes and pathological changes, most patients renal biopsy immunopathology will show that the patient has mesangial cell proliferation, as well as an increase in the mesangial matrix, and there will be a deposition of IgA-based immunoglobulins and related complement components in the patient's mesangial area and glomerular capillary loops. Thank you for your adoption.

Nephrology is a relatively young discipline in internal medicine. In the 50s of the 20th century, the development of percutaneous renal needle biopsy technology and the subsequent advent of blood purification technology laid the foundation for nephrology as an independent discipline. In 1960, the International Society of Nephrology (ISN) was founded.

Nephrology in China started late, and by the end of the 70s of the 20th century, only a few hospitals were involved in the diagnosis and development of kidney disease. In 1977, the Beidaihe Nephrology Academic Symposium was held as a milestone in the history of the development of nephrology in China, which comprehensively discussed and formulated the clinical diagnostic criteria and treatment plans for primary glomerular diseases, made pioneering contributions to the development of modern nephrology in China, and opened the prelude to the vigorous development of nephrology research in China in the past 30 years.

For the treatment of IgA nephropathy, there is currently no authoritative grading method and scheme. At present, most of the domestic programs are formulated based on clinical conditions and pathological classification, and the aspects that must be considered include renal function, proteinuria, hypertension and pathological classification. If you look at the pathological type alone, hormones alone may not be enough.

The addition of immunosuppressants may be more beneficial for disease control. It is recommended to go to the hospital to avoid aggravating the condition and delaying the time.

Symptoms of IgA nephropathy: the most important is the presence of hematuria, often secondary to upper respiratory tract infection with or without mild proteinuria, no edema, hypertension, and renal insufficiency (about 60% to 70%); Hematuria, proteinuria, hypertension, decreased urine output, and mild edema also occur in 10% to 15% of patients with acute nephritic syndrome.

Diagnosis is based on immunopathological examination of kidney biopsy specimens.

Laboratory tests: urine sediment shows polycythemia in the urine (predominantly deformed red blood cells) Urine protein may be occult (a few may show massive proteinuria) Blood IgA can reach 30% to 50%.

According to this, the above patients should be mild if they do not have problems with other systems of the body, and for patients with simple hematuria and slight proteinuria, no special ** is generally required, avoiding exertion, preventing colds, and avoiding the use of nephrotoxic drugs. For patients with recurrent tonsil infection, surgical removal is best to reduce the occurrence of hematuria and reduce IgA levels (surgery should be performed after infection control and stable condition).

Of course, in the end, it is hoped that the patient can go to a regular hospital for a regular examination and**.

There is no special method for IgA nephropathy, and different measures are adopted clinically according to the different manifestations and course of the patient, with the aim of protecting kidney function and slowing down the progression of the disease. Rest properly and avoid strenuous exercise, but when the condition is stable, proper exercise is necessary. Increase disease resistance, avoid cold, reduce the chance of infection, and once various infections appear, infection should be controlled as soon as possible.

The diet should be light, it is advisable to eat more fruits, vegetables and high-quality high-protein foods, prohibit spicy, fatty and sweet flavors, as well as moldy products, pickled foods, and avoid alcohol.

Yes, choose what way**.

There is no special method for this disease, and different measures are adopted clinically according to the different manifestations and course of the disease, with the aim of protecting kidney function and slowing down the progression of the disease. According to the clinical classification**IgA nephropathy is as follows:

1.Isolated microscopic hematuria.

No special ** is required, regular follow-up is required.

2.Reverse ** is the gross hematuria type.

For lesion removal such as tonsillectomy, triptyre** (tripterygium wilfordii, emodin, acei arb) can be used depending on the amount of proteinuria.

3.Abnormal urine test type.

Triptylene** (Tripterygium wilfordii polyglycosides, emodin, acei arb).

4.Vasculitic type.

1) MMF** regimen: Methylprednisolone intravenous infusion pulse** for three days, followed by prednisone, reduced by 5 mg daily to 10 mg daily every 2 weeks, and then maintained at this dose. MMF was started on 2 days, increased according to the blood concentration, and used for 6 months, maintained at a daily dose, and the total course of treatment was 2 years.

2) Cyclophosphamide (CTX)** regimen: methylprednisolone and MMF** regimen. CTX Shock**, once a month for 6 months, and every 3 months thereafter. The total dose is maintained with azathioprine after the end of **, and the total course of treatment is 2 years.

5.Massive proteinuria (with minimal lesions).

Prednisone regular**.

6.Massive proteinuria.

Low-protein diet with tripterygium wilfordii polyglycosides, emodin, acei arb drugs**.

7.Hypertensive type.

If you choose to use antihypertensive drugs such as acei ARB, CCB, and diuretics, you can use tripterygium wilfordii polyglycoside tablets together.