What causes elevated total bile acids?

The fasting serum total bile acids of normal people are less than 10 micromolar liters.

Bile is a thick, brown fluid in the gallbladder, and bile acids are the main components of bile. The liver is the only place where bile acids are synthesized and taken up from the portal vein, and bile acids are excreted through the biliary tract, so serum bile acid levels are associated with hepatobiliary disease, which is more common in elevated bile acids. In acute hepatitis, due to dysfunction of hepatic excretion and uptake of bile acids from the portal vein, bile acids are markedly elevated in all patients, reaching up to, and like aminotransferases, bile acids are another sensitive indicator of acute hepatocellular injury.

In mild chronic hepatitis, about one-third of patients have elevated bile acids, and in more severe cases, most patients have elevated bile acids, and the degree of bile acid elevation is basically parallel to the increase in aminotransferases and jaundice. In severe hepatitis, bile acids increase with the increase of jaundice, which is related to the severity of the disease. However, the level of bile acids is not completely parallel to the total bilirubin, when the level of bile acids reaches a certain level, the increase is slowed down, and the judgment of severe hepatitis is not as sensitive as bilirubin, the mechanism of this phenomenon is not clear, it may be that the concentration of serum bilirubin is too high or the presence of other substances interferes with the determination of bile acids.

When biliary obstruction and intrahepatic cholestasis, bile acids reflux into the blood due to obstruction of bile discharge, resulting in an increase in bile acids in the blood, and the degree of increase is basically parallel to the severity of the disease.

The determination of bile acids is of great significance in the diagnosis of cirrhosis. In a patient with chronic liver disease, cirrhosis is considered if the increase in bile acids is disproportionate to the increase in aminotransferases and bilirubin. of patients with cirrhosis have elevated bile acids, which are more valuable in the diagnosis of cirrhosis than aminotransferases and bilirubin.

Note: Bile acid measurement should not eat a large amount of fat and other indigestible foods the night before blood drawing, and do not eat 4 hours before blood drawing, otherwise it may affect the test results.

Bile acids are formed from cholesterol. Therefore, the concentration of bile acids can be controlled by controlling cholesterol intake.

A total bile acid (TBA) >10 mol L indicates hepatocellular lesions and elevated levels of bile acids in the blood. Bile acids are significantly elevated in acute hepatitis, chronic active hepatitis, liver cirrhosis, and liver cancer. In particular, the increase rate of total bile acids in liver cirrhosis and liver cancer (95%) is also greater than that of alanine aminotransferase (ALT) by 20%.

Normal bile is drained into the small intestine to aid digestion, while high total bile acids indicate blocked bile drainage, which indirectly indicates liver damage.

Solution: Vegetables such as cocoon and celery are rich in fiber, which can speed up the emptying of chyme in the intestine, shorten the retention time of toxic substances in the intestine and promote the excretion of bile acids.

?The high level of total bile acid is a potential threat to the body, and in the long run, it can induce various diseases to cause abnormal liver function, hepatocyte necrosis and other undesirable phenomena. So what are the reasons for high total bile acids?

In liver function tests, the normal serum total bile acids in a normal person are 0

10 mol l content. What are the causes of high total bile acids? Hepatologists from Henan Public Security Hospital pointed out that there are several main reasons for the high total bile acid:

1. A normal diet can also cause high total bile acids, but this situation can return to normal after a period of time. Recommendation: What causes high total bilirubin.

2. Total bile acids are mainly synthesized, decomposed and metabolized by the liver, when liver cells are damaged, the metabolism of bile acids will be abnormal, which leads to high total bile acids, chronic hepatitis, acute hepatitis, liver cirrhosis, liver cancer and other liver diseases will cause different degrees of total bile acids to be high.

3. Pregnant women can also cause high total bile acids, which are caused by abnormal bile acid metabolism and changes in hormone levels during pregnancy. Recommended: How to have high alpha-fetoprotein**High total bile acid is very harmful, patients must attach great importance to it, do a good job in preventive health care measures in life, develop good habits, eat more high-protein, high-fiber food, often eat fresh fruits and vegetables, balanced nutrition, in the case of paying attention to diet, but also regularly go to the hospital for re-examination, according to **, under the guidance of the doctor, actively cooperate**, so as to better prevent high total bile acid in the body, Eliminate the harm caused by high bile acids.

Total bile acids.

High levels indicate hepatocellular lesions and elevated levels of bile acids in the blood.

Acute hepatitis. Chronic active hepatitis.

Bile acids are significantly elevated in liver cirrhosis and liver cancer.

Hello this friend.

Total bile acids. The cause of elevation generally refers to pathological causes, such as multiple liver diseases

Hepatocellular damage.

Liver fibrosis. Liver cancer, hepatic hematoma, etc. It is recommended that you actively go to the hospital for hepatobiliary ultrasound or CT examination.

Diagnosed**Here**,Check out the original post" for adoption.

？There are many items of liver function tests, we all know that there will be a total bile acid when the liver function is checked, and in most cases, the total bile acid is found to be high during the liver function test, what is the reason? Now we specially invite Xiao Qinghua, director of Hunan 163 Hospital, a hepatologist, to give us all the reasons for the high total bile acid.

Regarding this problem, experts from Changsha Liver Disease Hospital pointed out that total bile acid is an important indicator of liver function test, total bile acid can reflect whether the liver is normal, total bile acid is synthesized and catabolized by the liver, so as to maintain the relative stability of human bile acid, and the normal reference value of total bile acid is.

Let's see what others have to say.

1. Elevation of bile acids caused by pathological causes. Hepatitis B Xiaosanyang (what is the harm of high total bile acids in liver function tests) patients will have an increase in bile acids when their condition deteriorates and liver damage, and hepatitis B Xiaosanyang patients should be paid attention to, which may be the deterioration of hepatitis B Xiaosanyang's condition to liver cirrhosis.

2. Elevation of bile acids caused by physiological causes. After eating, there will be a significant increase in bile acids in the serum, in which case the patient does not need to be nervous, and the level of bile acids will slowly decrease.

If you have any questions that you don't understand, you can consult me privately.

1. Normal physiological metabolism In the gallbladder, bile acids are highly concentrated, and after eating, the bile acid content in the duodenum increases significantly, which is one of the reasons for high bile acids, which belongs to normal physiological metabolism.

2. Causes of high bile acids, gastrointestinal diseases.

Gastric ulcers and enteritic diseases and colon diseases can cause elevated bile acids, a small part of which enters the peripheral circulation, and serum bile acid levels increase when intrahepatic and extrahepatic bile ducts are obstructed. In addition, secondary bile acids in the intestine enter the systemic circulation directly through the shunted portal system, which is manifested by an increase in serum bile acid levels.

3. Causes of high bile acids, caused by hepatobiliary diseases.

If hepatobiliary diseases are present, such as acute and chronic hepatitis, liver cirrhosis, alcoholic liver, etc., bile acids will be elevated. During acute hepatitis, bile acids in the blood are significantly elevated, and the level of bile acids in chronic hepatitis can distinguish active hepatitis from inactive hepatitis and monitor the effect. The concentration of bile acids in different stages of cirrhosis is also different, and the increase is most obvious in the later stage of cirrhosis.

In recent years, studies have found that bile acid content is more sensitive than other indicators for the detection of alcoholic liver, and the combination of serum bile acids and -hexaglycosaminidase is used as the most valuable detection method for alcoholic liver.

Knowing the cause of high bile acids, hepatologists also remind that bile acid testing plays a very important role in liver disease testing. When bile acids are high, the diagnosis must be confirmed in conjunction with other test results. Clinical practice has proved that the probability of bile acid conversion to cirrhosis is 88%, and biliary tract disease accounts for at least 65%.

Therefore, when bile acids are high, it is necessary to go to a regular large hospital for active diagnosis and treatment to avoid malignant diseases. For patients with high bile acids caused by viral hepatitis, it is important to do antiviral** as soon as possible to avoid long-term damage to the liver. Leads to liver fibrosis and the development of cirrhosis.

Best Liver Hospital in Kunming.

Experts from the Liver Disease Hospital Affiliated to Kunming Medical College pointed out that there are two main reasons for high total bile acids, one is high total bile acids caused by physiological factors, and the other is pathological factors. Among the physiological factors, the total bile acid of the human body will generally be high after eating, and this situation will return to normal within a certain period of time after eating, and will not cause harm to the human body.

In addition, pregnant women can also have high total bile acids, and pregnant women with high total bile acids are prone to intrahepatic cholestasis. Pregnant women with high total bile acids are caused by abnormal bile acid metabolism and changes in hormone levels during pregnancy, and pregnant women with high total bile acids are prone to intrahepatic cholestasis, which seriously affects the growth and development of the fetus.

Among the pathological factors, acute and chronic viral hepatitis, bile stasis, chronic ethanol poisoning, liver cirrhosis, primary liver cancer, biliary infarction and other diseases can cause high total bile acids, and because the production and metabolism of bile acids are very closely related to the liver, the increase in serum total bile acids usually means that hepatocytes have lesions, if not timely, it will not only seriously affect the quality of life of patients, but also may endanger the life safety of patients. Therefore, high total bile acids caused by hepatitis disease require hospitalization**.