What diseases are hemoglobinuria seen in, which are hemoglobinopathies

Urine contains free hemoglobin but no red blood cells, or only a few red blood cells but a large amount of free hemoglobin. Reflects the presence of hemolysis in the blood vessels that exceeds normal. There is no detectable amount of free hemoglobin in the urine under normal conditions.

When a large number of red blood cells are dissolved and destroyed in the blood vessels, the plasma free hemoglobin increases significantly, and hemoglobinuria occurs when the binding capacity of haptoglobin and the reabsorption capacity of the proximal renal convolva are exceeded. The appearance color of hemoglobinuria varies according to the amount of hemoglobin content, and can be uniform dark brown, wine, brown and soy sauce color, but the evidence for hemoglobinuria to judge hemoglobinuria based on the color of urine alone is insufficient, because the color of myoglobinuria, purple urine and black acid urine is also dark red, wine color and black, and the diagnosis can be confirmed by laboratory methods. In addition, it is necessary to make a diagnosis in a timely manner to correct it.

Intravascular and extravascular hemolysis are sometimes not easy to separate, and can be combined to varying degrees, and the main intravascular hemolysis is paroxysmal nocturnal hemoglobinuria, hemolytic anemia caused by glucose-6-phosphate dehydrogenase deficiency in patients taking certain drugs or eating broad beans, hemolysis caused by blood group incompatibility, cold agglutinin syndrome, paroxysmal cold hemoglobinuria, marching hemoglobinuria, hemoglobinuria caused by snake bites, hemoglobinuria caused by drugs or chemicals, Haemoglobinuria due to mushroom poisoning or severe burns, and haemoglobinuria due to acute hemolysis due to infection. Chronic hemolysis accompanied by hemoglobinuria during or around the period, clinical manifestations often include low-grade fever, low back pain, abdominal pain, and general malaise. In the acute intravascular hemolysis attack, it can show chills, high fever, obvious low back pain, limb soreness, chest tightness, shortness of breath, fatigue, headache, nausea, vomiting, abdominal pain, diarrhea and other symptoms, followed by the first urine is wine-colored, tan or even soy sauce-colored, and yellow staining can be seen in the sclera after the attack.

If acute hemolysis occurs under general anesthesia, it is manifested by severe bleeding from the surgical wound, a drop in blood pressure, and finally hemoglobinuria. Acute systemic reactions and hemoglobinuria may resolve within hours or days, but may persist longer.

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a.Vermilion survival is absolute, and dysrhizome is modified.

b.Hereditary elliptical polycythemia.

c.Sickle cell anemia.

d.Unstable hemoglobinopathies.

Correct Answer: Dan Manuscript Sui ACD

Answer] Jujube such as: d

The appearance color of hemoglobinuria is not the same as the amount of hemoglobin, and it can be uniform dark brown, grape wine, brown and soy sauce color.

Kidney disease, you should go to the hospital for examination and treatment in time.

Hemoglobin is a reflection of whether the human body has anemia. Hematuria, on the other hand, is considered to be due to nephritis. Recommended bacterial therapy, you can use Lingbai multibacterial powder, non-hormones, effectively eliminate urine protein, benefit the kidneys and nourish the kidneys, do not increase the burden on the kidneys, and can be taken for a long time.

(1) Glomerular diseases: primary or secondary glomerulonephritis, hereditary nephritis, thin glomerular basement membrane disease, etc.

3) Renal tubular diseases: renal artery embolism, renal vein thrombosis, left renal vein compression syndrome (nutcracker phenomenon), etc.

4) Trauma: kidney injury, urethral injury.

6) Urotract diseases: urinary stones, urinary tract infection (a few patients have obvious hematuria), prostatic hyperplasia, etc.

7) Congenital renal or urinary tract malformations.

8) Others: low back pain, hematuria syndrome, renal prolapse, etc.

Through Director Ji's answer for you, you already have an understanding of the ** that causes hematuria. If you are such a patient, please choose the best nephrologist - the Third Hospital of the Beijing Armed Police Corps. There are the most professional nephrologists and advanced medical equipment, especially the original "biological cell transplantation" is to identify, isolate, purify, expand and culture high-quality biological cells in vitro through puncture, minimally invasive intervention or intravenous injection and other ways to implant biological cells into the patient's body, the use of biological cells themselves with targeted characteristics, so that they can be planted to the lesion site to repair the lost tissue function, so as to achieve the purpose of the first.

Hope you can do it soon**.

Hemoglobinuria is mainly due to the destruction of large amounts of red blood cells due to various causes and their release into the bloodstream. The resulting hemoglobin is formed by far exceeding the binding capacity of the liver and the reabsorption capacity of the renal tubules. Strongly positive for occult blood, no red blood cells on microscopic examination.

Myoglobinuria is a condition in which myoglobin is excreted in urine when tissues such as cardiac muscle or skeletal muscle are severely damaged, and myoglobin can be detected by trans-urine MB testing.

Myoglobinuria is also often accompanied by the destruction of red blood cells due to muscle damage, so myoglobinuria is also accompanied by hemoglobinuria.

Hematuria is the presence of red blood cells in the urine.

Hematuria is the presence of red blood cells in the urine.

Hematuria is positive for occult blood, and red blood cells are found on the microscope.

Myoglobinuria & hemoglobinuria occult blood test was positive, and there were no red blood cells on microscopic examination.

Both myoglobinuria and hemoglobinuria are positive occult blood tests because they both test for porphyrins. The identification of the two can be done by ammonium sulfate precipitation experiment. Because hemoglobin can be precipitated by ammonium sulfate, myoglobinuria is still positive after the ammonium sulfate precipitation test.

porphyria, no red blood cells on microscopic examination, negative occult blood test; Teeth are brown due to pigmentation; Increased amount of porphyrins in feces and urine.

This information is an excerpt from Doctor.com.

If myoglobinuria is positive, it may be seen in extensive muscle damage or in muscle disease. Phosphorylase deficiency can also be positive Hemoglobinuria When intravascular hemolysis occurs, and hemoglobin exceeds the binding capacity of hepatoglobin, free hemoglobin is filtered out of the glomeruli, forming varying degrees of hemoglobinuria Red blood cells are not seen on microscopic examination or occasional debris of lytic red blood cells, and the occult blood test is strongly positive Hematuria: It refers to the presence of a certain amount of red blood cells in the urine, which is called hematuria v If more than 3 red blood cells are seen in each high-power field of view, it can be determined as microscopic hematuria.