What medications do patients with muscle weakness need to take?

Myasthenia gravis medications**:

1) Cholinesterase inhibitors: symptomatic drugs, treating the symptoms but not the root cause, can not be used as a single drug for a long time, and the medication method should be gradually increased from a small dose. Commonly used are neostigmine methyl sulfate and pyridostigmine bromide.

2) Immunosuppression: Commonly used immunosuppressants are: adrenocorticosteroid hormones: prednisone, methylprednisolone, etc.; azathioprine; Circumferin A; cyclophosphosamine; Tacrolimus.

3) Plasmapheresis: Temporarily alleviate the symptoms of patients with myasthenia gravis by removing acetylcholine receptor antibodies from the patient's blood, and the effect will not exceed 2 months if other methods are not adjuvanted.

4) Intravenous immunoglobulin: human immunoglobulin contains a variety of antibodies, which can neutralize autoantibodies and regulate immune function. Its effect is comparable to that of plasmapheresis.

5) Traditional Chinese Medicine**: Traditional Chinese Medicine for Myasthenia Gravis has received more and more attention. Myasthenia gravis falls under the category of "dysentery".

According to the theory of traditional Chinese medicine, the addition of traditional Chinese medicine can reduce the risk of immunosuppressants, play an escort role in the treatment of myasthenia gravis, and can rebuild the effect of autoimmune function. For details, it is recommended to consult the doctor of Wuhan Modern Obstetrics and Gynecology in Qiaokou. Myasthenia gravis contraindicated or used with caution:

1. If antibiotics are needed for patients with muscle weakness, according to different adaptation strains, the ones that can be used are pioneermycin, penicillin, chloramphenicol, erythromycin, spiramycin and medisomycin, and the anesthetics can be used such as: novocaine (procaine), laughing oxygen, and cyclopropane. Sedatives are omitted, and penicillin should be tested first.

2. If the above antibiotics are ineffective, aminoglycoside antibiotics, xin, kana, qingda, and paromomycin can be used with caution. However, it must be used in conjunction with neostigmine drugs and the dosage of the latter should be increased accordingly. Tetracyclines should be used with caution.

3. It is best not to use polymyxomyx, do not use two antibiotics that have a blocking effect on the neuromuscular junction at the same time, do not use muscle relaxants, anesthetics and sleeping sedatives at the same time, and do not use mucosal and serous administration methods.

4. Patients with myasthenia gravis with kidney disease and poor renal function should not be treated with antibiotics that have a blocking effect on the neuromuscular junction.

5. Fluoroquinolones such as haloperic acid can also aggravate the symptoms of muscle weakness and should be used with caution. Other: quinine, quinidine, chloroform, curare, ether, succinamide.

Succinylcholine, morphine, cocaine, hypnosin, chloral hydrate, luminal, hypnotone, demerol, puromycin, barbiturate, procainamide, lidocaine, propranolol. Doctors disagree with each other: diazepam, diazepam, diazepam.

When muscle weakness occurs, there are several symptoms, which are muscle weakness.

1. Dysphagia: The early symptoms of myasthenia gravis are no digestive tract diseases, and the appetite is good, but I can't swallow good food and food, and I can't even swallow water. When you drink water, you either choke on your trachea and cough or it comes out of your nostrils.

Some patients have severe dysphagia and must rely on a nasogastric tube for feeding.

2. General weakness: The early symptoms of myasthenia gravis look good from the outside, and there is no muscle atrophy, as if there is no disease, but the patient often feels severe general weakness, unable to lift shoulders, unable to lift hands, unable to stand up when squatting, and even relying on others to help wash his face and comb his hair. The patient's muscle weakness symptoms improve significantly after resting for a while, and they will be significantly worse after a little work, as if they are pretending.

3. Double vision: that is, double vision. Seeing together with two eyes, one thing becomes two; If you cover one eye, you see one.

Very young children do not describe diplopia, and often compensatorily tilt their heads and torticollis so that they can see clearly because of their disappearance, and in severe cases, they can also manifest as strabismus.

Analysis: Myasthenia is an acquired autoimmune disease of impaired neuromuscular junction transmission, characterized by the fatigue of the affected skeletal muscles, which worsens with exertion and improves with rest and anticholinesterase drugs. Guidance:

1.Western Medicine** (1) Anticholinesterase drugs: neostigmine, 15 45mg each time, 4 6 times a day; or pyridostigmine 60 150 mg every 3-6 hours.

Atropine can be taken concomitantly to counteract side effects. Adjuvant drugs such as potassium chloride and ephedrine can enhance the efficacy. (2) Immunosuppressant corticosteroids:

Prednisone 60 70 mg orally daily or every other day, can be reduced to the smallest effective dose after symptom remission. Immunosuppressants: cyclophosphamide 200mg daily, divided into 2 3 oral doses; or azathioprine 50 150 mg daily orally in 2 3 divided doses.

3) Thymectomy: The effect of thymic hyperplasia is better than that of thymoma. (4) Plasma exchange**.

5) Crisis management: keep the airway open. A tracheostomy or nasal intubation should be done as soon as possible, with nasogastric tube placement and breathing assistance.

If the symptoms are significantly reduced after the injection of Tensilone, the dose of anticholinesterase drugs should be increased, and the anticholinesterase drugs should be discontinued for cholinergic and reflux crises. At the same time, the intake and output and water and salt balance should be maintained to prevent complications such as lung infection. 2.

Traditional Chinese Medicine** (1) Liver and stomach qi deficiency: drooping eyelids or double vision, weakness of limbs, sluggish abdominal distention, loose stools, yellowish complexion, low voice and shortness of breath, sweating from time to time, tooth marks on the pale edge of the tongue, thin white moss, and pulses.

**Myasthenia gravis drugs mainly include pyridostigmine bromide, as well as hormones and immunosuppressants. With corticosteroids and pyridostigmine bromide**, immunosuppressants can be eliminated if they can be controlled. If corticosteroids and pyridostigmine bromide are inadequate, immunosuppressants may be added to modify and control the symptoms of muscle weakness.

There are other factors that cause muscle weakness, mainly autoimmune peripheral demyelinating neuritis, nerve roots, which need to be given immunoglobulin and plasma exchange ** to improve symptoms, and some patients can also be treated with large doses of hormonal shocks**, as well as peripheral nerve diseases, such as diabetes, which need to be controlled. There is also muscle weakness caused by drinking, and vitamin B1 supplementation is required. There are other myositis that can also cause muscle weakness and require hormones and antibiotics**.