What are the manifestations of motor neuron lesions?

Motor neuron disease is a progressive disease involving the locomotor system, which can appear in the early stage of muscle beating, irregular position, and gradually appear weakness and muscle atrophy of the hand, which gradually spreads to other limbs, and some patients also have difficulty swallowing, neck muscle weakness, difficulty raising head, etc. Some patients may have respiratory muscles involved later in the course of the disease, causing respiratory paralysis and requiring a ventilator to assist breathing.

Motor neuron disease is generally not accompanied by sensory impairment, cerebellar involvement such as ataxia, or visual disturbances. Very few people with MND have intellectual disability and may have frontotemporal dementia, but the main symptoms of MND are muscle weakness and atrophy.

Symptoms of muscle atrophy, weakness, and tremor are the main symptoms. Usually the muscles between the palms and fingers are atrophied, the mouth is atrophied, and the muscles that slowly deteriorate to the shoulders, neck, tongue, and swallowing are all manifestations of this manifestation.

Common manifestations of MND include muscle weakness, muscle atrophy, fasciculations, muscle spasms, dysphagia, choking, and slurred speech.

The internal organs are deficient, the qi, blood and fluid are insufficient, and the muscles, veins, and muscles of the limbs are not nourished.

Disease analysis: There are many motor neuron degenerative diseases, and it is difficult to do so in the later stages of the disease. When the disease is severe, it can invade the anterior horn cells of the spinal cord, the nucleus of brain stem cells, and the pyramidal cells of the motor cortex of the brain, causing dyspnea and dysphagia, which are life-threatening.

Seven percent of patients have genetic immunoabnormalities or viral infections. The remaining patients** are unknown, with reports of heavy metals, chemical poisoning, and the surrounding environment. All data such as medical history, symptoms, pathology, and MRI of the brain to determine effective measures to eliminate the disease, nutrition and excitatory activation on the basis of exacerbation of neurological disease, which can only be achieved on the basis of further resuscitation.

How long has this been the case.

Motor neuron disease (MND) is a syndrome of impotence in traditional Chinese medicine, which is a syndrome of sluggish and weak limb muscles. Traditional Chinese medicine believes that the kidney is the innate foundation, the main essence is stored, and the bone is the marrow. In traditional Chinese medicine, it is most closely related to the kidneys, with insufficient congenital endowment, lack of sperm and blood, and inability to nourish muscles, muscles and bones, and gradually muscle weakness and atrophy.

At the same time, the spleen and stomach are the foundation of the day after tomorrow, metamorphosis generates qi and blood, nourishes the five internal organs, muscles, muscles and bones, and the spleen is the main muscle, the spleen and stomach are weak, the biochemistry of qi and blood is insufficient, and the muscles are not nourished, so the muscles are atrophied and weak.

**Unknown It is recommended to take Chinese medicine for conditioning.

The exact nature and pathogenesis of motor neuron disease are unknown. It may cause the accumulation of toxic substances in the nervous system for various reasons, especially the increase of free radicals and excitatory amino acids, and damage nerve cells and cause disease.

First, the main **.

1. Genetic factors: most of the motor neuron disease is sporadic, a few have a family history, and the inheritance mode is mainly autosomal dominant. The most common causative gene is the copper (zinc) superoxide dismutase (SOD-1) gene on chromosome 21.

2. Infection and immunity: Some researchers believe that the onset of the disease may be related to poliovirus, enterovirus, and human immunodeficiency virus (HIV), and when the infection invades neurons, patients will have corresponding clinical manifestations.

3. Metallic elements: The onset of motor neuron disease may be related to certain metals, such as lead, mercury, aluminum, etc., and the difference in the content of metallic elements in the environment may also be the reason for the high incidence of geography in some regions.

4. Nutritional disorders: Some researchers have found that vitamin B1 and vitamin B1 monophosphate in the plasma of patients with amyotrophic lateral sclerosis (ALS) are reduced, which may lead to normal metabolic disorders of neurons, which in turn leads to amyotrophic lateral sclerosis.

5. Neurotransmitters: The level of inhibitory neurotransmitter GABA in the cerebrospinal fluid of ALS patients is significantly reduced, while norepinephrine is increased, and the more severe the disease, the more obvious this change is, and some studies have shown that the neurocytotoxic effect of excitatory amino acids (mainly glutamate and aspartic acid) plays an important role in the pathogenesis of ALS.

This disease is very common in our daily life, but most patients find that they have this disease, but they do not understand the cause of this disease.

1. What are the main motor neurons**? Viral infection and immunodeficiency are a toxic disease caused by anterior horn cell toxicity, and some people believe that human immunodeficiency virus can cause damage to the spinal cord and may cause motor neuron disease, and the immune function measured in patients has found elevated immunoglobulins, immune complex formation, and positive antiganglioside antibodies.

2. Metal elements: Some scholars believe that the occurrence of this disease is related to the lack of some metal poisoning and some metal element deficiencies.

3. What are the main motor neurons**? Other factors: Some scholars believe that genetic factors can also cause the disease.

According to statistics, 5% to 10% of cases have a tendency to run in families, and coconut oil scholars believe that the occurrence of this disease is also related to nutritional disorders, metabolic endocrine, enzyme deficiencies and hypoxia.

Tips: The above is about the question of "what are the main motor neurons", I believe everyone understands, and finally reminds everyone: after understanding the motor neurons, we must pay attention to reasonable prevention.

For some patients who have already been diagnosed, it is necessary to do it promptly.

There are many different types of MND and their manifestations vary.

Clause. 1. Amyotrophic lateral sclerosis is manifested as insidious onset, progressive course, onset after the age of 40, men are a little more than women, and the average survival time is three to five years. Dysmobility of small motor movements of the hand, decreased strength, atrophy of the hand muscles and gradual involvement of the proximal extremities, decreased or absent tendon reflexes of the upper extremities, spastic paralysis of the lower extremities, occasional subjective sensory abnormalities, no objective sensory impairment, and sphincter involvement.

Clause. 2. Progressive bulbar palsy, which begins after middle age, generally has a poor prognosis, and most of them die one to three years after the onset of the disease. There are unclear arthria, choking on drinking water, dysphagia, atrophy of tongue muscles, loss of gag reflex, and coexistence of true and false bulbar paralysis.

Clause. 3. Progressive musculospinal atrophy occurs in more men around the age of 30, and the first symptoms mostly start from the hands, and then the paralysis sensation and sphincter ability are normal, and gradually affect the entire upper limbs.

Clause. 4. Primary lateral sclerosis.

Western medicine believes that MND is a progressive chronic neurological pathology, which is more likely to invade the anterior horn cells of the spinal cord, the motor nerve nucleus of the brainstem, the cerebral cortex and the pyramidal tract, so patients often have symptoms such as muscle weakness, muscle atrophy, muscle beating and increased muscle tone. The specific manifestations of the lower limbs are weakness in walking, unsteadiness, easy to fall or procrastination; The specific manifestations of the upper limbs are inflexible fingers and slow movements. In addition, a small percentage of patients present with dysphagia, speech dysfunction, or breathing disorders.

Manifestations of motor neuron disease: muscle weakness, muscle atrophy, and fasciculations are manifestations of lower motor nervous system involvement; Hypertonia, hyperreflexia, and positive pathological signs are the main manifestations of upper motor nervous system involvement. The presenting symptom can be a variety of manifestations depending on the patient.

Most patients have asymmetrical local limb weakness, such as stiff walking, procrastination, easy falling, and inflexible finger movement. Bulbar symptoms such as dysphagia and dysarthria. A small number of patients present with respiratory symptoms.

Weakness in the limbs, inability to lift the arms, difficulty walking. Difficulty breathing, difficulty swallowing, slurred speech, muscle atrophy, etc.

Motor neuron disease is a degenerative disease that originates from the motor nerve, and the specific cause of the disease is unclear, it can be damage to the upper motor nerve or the damage to the lower motor neuron, so there are four conditions:

Clause. 1. Injury that originates from upper motor neurons and manifests only as lateral sclerosis.

Clause. 2. Injury to lower motor neurons is the injury of lower motor neurons of the lower cranial nerves of the brainstem, manifested as primary bulbar palsy.

Clause. 3. Damage to the lower motor neurons of the spinal nerves of the limbs, manifested by progressive spinal muscle atrophy.

Clause. Fourth, there are lesions in both upper and lower motor neurons, which are called amyotrophic lateral sclerosis.

Motor neuron disease refers to the unexplained degenerative disease of upper and lower motor neurons, which is mainly divided into the following four types:

1. Primary lateral sclerosis is simply involving upper motor neurons, which is only manifested as tendon hyperreflexia, positive pathological reflexes and muscle weakness.

2. The disease in which both upper and lower motor neurons are involved is called amyotrophic lateral sclerosis, which has both the manifestations of lower motor neuron damage, that is, muscle atrophy, and the manifestations of upper motor neuron damage, such as tendon hyperreflexia, pathological positive reflexes, etc.

3. Simply involving lower motor neurons, if only the descending motor neurons of the brainstem are affected, it is called progressive bulbar palsy, which is manifested as difficulty swallowing and chewing, choking or being unable to swallow or speak.

Fourth, the lesion that only involves the motor cells of the anterior horn of the spinal cord is called progressive spinal muscular atrophy, which is only manifested as atrophy and weakness of the limb muscles, accompanied by flesh beating.

Motor neurons are neurons that are responsible for transmitting messages from the spinal cord and brain to the muscles and endocrine glands that innervate organ activity. Motor neuron disease (MND) is a rare disease that is a series of chronic progressive neurodegenerative diseases characterized by motor neuron changes. At present, the cause of the disease is not clear, and patients present with muscle weakness, muscle atrophy, bulbar paralysis, etc., and usually have no paresthesias.

The disease mostly occurs in middle-aged and elderly people, and the course of the disease is mostly 2 to 6 years, and most of them have a poor prognosis, and often die of respiratory muscle paralysis or lung infection due to respiratory muscle involvement.

There is still a lack of drugs that can effectively reverse or control the progression of the disease. The motor neuron disease pathogen is diverse and affects each other, so it must be a combination of multiple methods. The ** of motor neuron disease includes **, symptomatic ** and various non-pharmacos**.

At present, there is no specific diet to avoid for MND, and a balanced diet is sufficient.

The nursing of patients with motor neuron disease should always pay attention to the nutritional status, swallowing function and respiratory status of the patients, care about the psychological status of the patients, keep the environment clean and tidy, and reduce the occurrence of complications.

Take the drug according to the doctor's instructions, understand the possible adverse reactions of the drug, and regularly review the blood routine and liver and kidney function during the medication.

Depending on their condition, patients should do some appropriate exercises under the guidance of a doctor.

For patients who have been bedridden for a long time, the surrounding environment should be kept clean and tidy, and family members or nursing staff should help patients turn over, pat their backs, massage, and scrub on time every day to reduce the occurrence of complications such as infections and bedsores.

Patients with dysphagia should slow down their eating and try to avoid aspiration.

Amyotrophic lateral sclerosis can occur, with signs of lower motor neuron damage, i.e., muscle atrophy, and upper motor neuron damage, such as tendon hyperreflexia, pathological reflex positivity, and so on.