Is it okay to take cephalexin in the morning and drink alcohol at night

No, cephalexin is accumulated in 24-hour urine to excrete 80% to 90% of the dosage.

This product is well absorbed, and the peak concentration of blood drug (Cmax) is reached 1 hour after oral administration of 500mg of this product on an empty stomach, with an average of 18mg L. Taking the drug after a meal prolongs the absorption and lowers the peak blood concentration, but the absorption does not decrease. The absorption of this product can be increased in young children with celiac disease and small intestinal diverticulum, and can be delayed and decreased in patients with Colonopathy and pulmonary cystic fibrosis.

Although gastrointestinal absorption is not reduced in the elderly, the blood concentration is maintained for a longer period of time than in the younger people. The blood elimination half-life (T1 2) of this product is hours, and the addition of probenecid can increase the blood concentration, and T1 2 can be extended to hours; T1 2 can be prolonged to 5 to 30 hours in renal failure; Newborn T1 2 hours. After absorption, this product is widely distributed in the body fluids of various tissues, and the average concentration in sputum after oral administration of 500mg every 6 hours is higher, and the concentration in purulent sputum is higher.

The concentration of the drug in the pus is basically equal to the blood concentration, and the concentration of the drug in the exudate of the joint cavity is 50% of the blood concentration. This product can enter the fetal blood circulation through the placenta, maternal amniotic fluid; The milk concentration after oral administration of 500 mg in lactating women is 5 mg l. About 5% of the oral dose is excreted from bile, which is 1 4 times the blood concentration.

Serum protein binding rate is 10% to 15%. This product is not metabolized in vivo, 80% 90% of the dosage is accumulated in urine in 24 hours, and the peak urine concentration can reach 2200mg L after oral administration of 500mg. Cephalexin can be removed by hemodialysis and peritoneal dialysis.

It is best not to drink alcohol, and some people take several days to recover. The function of the liver to metabolize hangover.

It's okay not to eat 8 hours before drinking.

It may cause a toxic reaction, you can't drink alcohol during the conditioning of the body, and you can't use drugs after drinking**, these are responsible for the body, otherwise there is no great point in using drugs.

Analysis: Do not drink alcohol. You can't drink alcohol for a few days after eating cephalosporins.

Alcohol and cephalosporin antibiotics together will undergo disulfiren reaction, cephalosporin antibiotics inhibit the activity of aldehyde dehydrogenase that converts acetaldehyde, resulting in acetaldehyde (the liver is rich in ethanol dehydrogenase, which can dehydrogenate alcohol to produce acetaldehyde that is more harmful to the human body) can not be eliminated and piled up in the blood, resulting in poisoning symptoms, such as facial fever, flushing, headache, severe cases may have dyspnea, vomiting, nausea, sweating, shock and other violent reactions, which can cause respiratory depression, arrhythmia, myocardial infarction, Heart failure and even death. The severity of the reaction is directly proportional to the dose of medication and the amount of alcohol consumed.

Suggestions:**: The first thing is to stop drugs or alcohol, the symptoms can be reduced or disappeared, and those with severe reactions can be given dexamethasone to glucose solution intravenously drip or intravenous push, rehydration and diuresis, and vasoactive drugs according to the condition**.

If nausea and vomiting are present, metoclopramide can be given intramuscularly; If drowsiness and confusion occur, naloxone can be given to counter **. It is also necessary to pay attention to the prevention of anti-drug use, and do not drink alcohol and alcoholic beverages during the period of application and even within 5 days of stopping the drug.

Is it okay to drink 12 o'clock at night if you eat cephalosporin in the morning?