About membranous nephritis nephrotic syndrome 10

Experts from Changsha Puji Kidney Disease Hospital said that before talking about how to ** nephrotic syndrome, we should first talk about the two questions of "why nephrotic syndrome occurs" and "whether nephrotic syndrome is contagious". Let's start with the causes of the disease: the primary and secondary factors.

Generally, due to autoimmune deficiency, mucosal infection continues to act on the glomeruli for a long time, destroys the self-regulation function of the glomeruli, forms a large number of immune complexes circulating and depositing glomeruli in the blood, promotes local microcirculation disorders in the glomeruli, damages the inherent cells in the kidney, causes the destruction of the normal physiological structure of the kidney, and initiates renal fibrosis. The anion charge on the surface of podocytes decreases or disappears, the negative charge of the basement membrane decreases, the glomerular basement membrane barrier function is damaged, and a large amount of protein leaks, so it is called glomerular epithelial cell and podote cell disease. The occurrence of massive proteinuria also indicates the impairment of renal tubular reabsorption, that is, a large amount of protein enters the renal tubule, and due to the proximal convoluted renal tubular reabsorption overload, it damages the lysosomes of the canal wall, increasing its activity into the epithelial cells, resulting in epithelial cell damage. After injury, renal tubular epithelial cells attract inflammatory cells into the renal interstitium, causing an interstitial inflammatory response.

Another problem is the contagion of nephrotic syndrome. Nephrologists point out that in fact, except for some special types, kidney disease is generally not contagious. Nephrotic syndrome refers to a clinical syndrome of massive proteinuria, hypoalbuminism, marked edema, and hyperlipidemia of various causes.

Nephrotic syndrome can be caused by a variety of glomerular diseases, which are divided into two categories, primary and secondary, and are not infectious diseases.

If you want to be good at kidney disease, I think the most important thing is to have the effect, find a real nephrologist who has research in this area, and the scientific research results of kidney disease they have made are recognized by the state, and have good results in some aspects of kidney disease, maybe your kidney disease can be cured by him, rather than looking for a big hospital. Only then can there be hope of being cured of your illness. This is the most important, and the dosage should be appropriate, focusing on which kidney disease may get better faster.

It is impossible for hypertensive nephropathy to reach this period**, but it is good to be able to control the condition, as long as the condition does not worsen! I have a relative with similar symptoms to yours, he saw it in the 309 Hospital of the People's Liberation Army, and it did not deteriorate after **, and now he is in good health!

Membranous nephropathy is a pathological type that is difficult to recover from nephrotic syndrome, with a slow onset of action, but if it is regular, the probability of future disease is small, and you must go to a regular hospital to be reasonable, and the symptoms of edema can be relieved by taking drugs such as torsemide, but the root cause of the disease should be timely! Wish!

I don't really understand why you stopped taking hormones. Hormones can reduce proteinuria, corticosteroids are necessary for nephrotic syndrome, and acei drugs can also be used to reduce proteinuria.

Membranous glomerulonephritis is one of the common pathological types of nephrotic syndrome. It is a pathological diagnosis, which refers to the deposition of immune complexes under the epithelial cells of the visceral layer of the glomeruli, resulting in a series of pathological changes in the glomerular basal orange membrane. Typical findings are diffuse heterogeneous thickening of the glomerular basement membrane and nail process formation.

According to the traditional pathological stage, membranous nephropathy can be divided into five stages.

Pathologic features of membranous nephropathy.

1.Light microscopy: diffuse "nail process" formation or uneven thickening of glomerular capillary basement membrane;

2.Immunofluorescence: IgG and C3 are deposited in the form of particles on the glomerular capillary wall;

3.Electron microscopy: electron dense matter is deposited under the epithelial cells (podocytes) of the visceral layer of the glomeruli, and the podocytes are diffusely fused.

Differential diagnosis. 1.Secondary membranous nephropathy.

Such as hepatitis B, hepatitis C virus-associated nephritis, lupus nephritis, etc. It can be distinguished by clinical data and laboratory tests, especially the PLA2R (serum screening for PLA2R antibody, renal tissue screening Ig (G1, G2, G3, G4) and PLA2R discovered in recent years, which brings great convenience to distinguish primary secondary MN disease.

The following pathological findings can be used to distinguish primary and secondary pathologies.

Under light microscopy: whether glomerular basement membrane lesions are accompanied by other lesions, such as moderate and severe hyperplasia of mesangial cells, endothelial cell hyperplasia, segmental necrosis, etc.

Immunity: whether it is "full house", that is, IgA, IgG, IgM, C3, C4, C1Q, and FIB are all strongly positive, especially C1Q is strongly positive, which is highly suggestive of secondary diseases;

Under electron microscopy: whether there are electron-dense deposits in the mesangial area of the glomerular or other areas, except for electron-dense deposits in the epithelial cells of the visceral layer of the glomerulium.

2.Hematologic disorders.

For example, plasma cell disorders, kidney damage associated with monoclonal globulin deposition, amyloidosis, lymphoma, etc. Early lesions of these diseases can often manifest as simple thickening of the glomerular basement membrane, especially in patients over 50 years of age. It is best to routinely add kidney tissue Congo red staining or Kappa and LAMADA light chain immunofluorescence immunohistochemistry to avoid missing the diagnosis.

In addition, it needs to be validated with clinical data.

Membranous nephropathy should be distinguished from minimal change and early diabetic nephropathy; Membranous nephropathy should be distinguished from membranous proliferative nephritis. Where possible, it is advisable to improve electron microscopy.

Hello, the identification method of nephrotic syndrome is three highs and one low, hyperedema, hyperlipidemia, hyperproteinuria, hypoproteinemia, membranous nephropathy If this condition is present, it can also be called nephrotic syndrome. Membranous nephropathy is a pathomorphological diagnostic term characterized by the presence of large amounts of immune complexes on the epithelial side of the glomerular capillary folds. It is more common in patients over 40 years of age, and most patients begin with nephrotic syndrome, and about 20% of patients present with asymptomatic, non-nephrotic proteinuria.

The difference between these two diseases is very large, although the clinical manifestations are basically very similar, but the main difference is the pathological examination guidance:

That is to say, among all nephritis classifications, the main basis is pathological examination results, which is the main label of the classification, followed by clinical manifestations.

The difference between these two diseases is very large, although the clinical manifestations are basically very similar, but the main distinction is pathological examination, that is, in all nephritis classifications, the main basis is the pathological examination results, so that the main label of the classification is the clinical manifestation, followed by the clinical manifestations.

Hello, if you suffer from this membranous nephropathy, you should pay attention to rest, avoid exertion, prevent infection, eat a low-protein diet, pay attention to vitamin supplementation, and avoid the use of drugs that damage the kidneys.

Nephrotic syndrome is a clinical diagnosis, whereas membranous nephropathy is a pathological diagnosis below the clinical diagnosis, and they are in a relationship of belonging to and belonging.

In the early stage of nephrotic syndrome, symptoms such as edema, fatigue and foamy urine in the lower limbs, especially in the ankle area, are generally present, and some patients have no obvious discomfort symptoms, which are found through physical examination. If there are symptoms such as edema and foamy urine of the lower limbs, it is necessary to go to the nephrology department to find a doctor for examination, laboratory urine routine, renal function, 24-hour quantitative measurement of urine protein, and if necessary, it is necessary to do a pathological diagnosis of renal puncture to make a clear diagnosis.

1.Non-immune**.

For urine protein quantification, young patients with normal or mildly reduced plasma albumin and normal renal function.

Nephrotic syndrome refers to a group of syndromes caused by a variety of **, mainly glomerular lesions such as increased glomerular basal membrane permeability with decreased glomerular filtration rate. In nephrotic syndrome, this barrier is impaired and protein filtration is increased, resulting in proteinuria. Patients with nephrotic syndrome can take it effectively in the early stages, and it is basically possible to recover in about six months.