Who is susceptible to myasthenia gravis?

Myasthenia gravis is a relatively common disease, mainly caused by the transmission function of the nerve and muscle junction, the occurrence of this disease will have a great impact on the patient's body, and in severe cases, it will directly limit the patient's activities. This disease has a certain directionality, and usually, its high-incidence groups mainly include patients with immune diseases, women and sub-healthy people.

Myasthenia gravis is a serious disease that occurs due to abnormalities in the immune system. In addition, if the patient is in a state of exertion or stress for a long time, it may also cause the occurrence of diseases. In the early stage, patients will have symptoms such as sore limbs and fatigue, and as the disease progresses, patients will have problems such as blurred vision, strabismus, double vision, and some patients' ability to swallow food will also be reduced.

If left unchecked, the disease can eventually lead to a myasthenic crisis. Although the incidence of this disease is very widespread, it still has a certain target, and the following is a specific introduction to the people with a high incidence of this disease.

1. Female. This disease is common in women between the ages of 20 and 40, and women are more likely to develop this disease during menstruation or when they have a cold. First of all, during the menstrual period, the amount of estradiol in the woman's body will increase, and this substance will promote the secretion of prolactin to a certain extent, which will lead to abnormal immune function and cause myasthenia gravis.

Secondly, patients are also prone to upper respiratory tract infections when they have a cold, which can induce diseases.

2. Sub-healthy people.

Compared to healthy people, sub-healthy people have a much higher chance of developing myasthenia gravis than healthy people, because they have some problems of their own. Too many sub-healthy people have poor habits in life and diet, and are particularly susceptible to environmental influences, which leads to the occurrence of diseases.

3. Patients with immune diseases.

Specific immune diseases mainly include immune thyroiditis, Hashimoto's disease, etc., among which thyroiditis patients will also cause abnormalities in the immune system due to hypothyroidism, thereby causing myasthenia gravis.

People with a high incidence of myasthenia gravis often have the following types of conditions: 1. Have a family history: that is, the disease occurs in the parents of the family and the previous generation, or there are similar autoimmune diseases, such as rheumatoid arthritis or immune thyroiditis, etc., the offspring are susceptible to the disease; 2. Autoimmune diseases:

For example, Hashimoto's disease, or immune thyroiditis, hypothyroidism or goiter, patients with high thyroid autoantibodies, and rheumatoid combined with lupus or other immune diseases are also at risk.

Patients with poor immunity and abnormal autoimmune function, or a malignant tumor that causes immunocompromise, or thymoma are susceptible to myasthenia gravis.

Sub-healthy people are more likely to suffer from myasthenia gravis. The so-called sub-health is a state in which the body has no organic lesions, but there are some functional changes, which we call sub-health status. In popular understanding, sub-health refers to a non-disease and non-healthy state.

Myasthenia gravis (MG) is a chronic autoimmune disease caused by dysfunction of transmission between nerves and muscles. The disease has a tendency to be in remission and **, can occur at any age, but more often in children and adolescents, women are more common than men, and the onset of the disease in later life is more likely to be men. The clinical manifestations are that the affected striated muscles are easily fatigued, and this weakness is reversible and can be recovered with rest or anticholinesterase drugs, but it is easy to **.

Patients with myasthenia gravis of different ages have different clinical manifestations and course of disease. Myasthenia gravis in children, almost 100% of cases are mainly ophthalmofacial involvement, manifested by drooping eyelids, diplopia and eye motility. The condition is sometimes good and sometimes bad, or alternates left and right.

In addition, the medullary innervation muscle, shoulder girdle muscle, neck muscle, trunk muscle and upper and lower limb muscles can be involved, and if you speak for too long, your voice will gradually be low, and your arthria will be unclear and nasal, and due to the weakness of the jaw, soft jaw, swallowing muscle, intercostal muscle, etc., it can affect the chewing and swallowing function and even dyspnea.

Myasthenia gravis is caused by the composition of the postsynaptic muscle cell membrane and the synaptic cleft between the two. It activates when a motor command is passed down from a presynaptic motor nerve ending; Myasthenia gravis is caused by the release of the chemical transmitter acetylcholine into the synaptic cleft by synaptic vesicles, which move through the gap to the postsynaptic muscle cell membrane and the postsynaptic muscle cell membrane. Patients with myasthenia gravis generally vary widely in the extent and degree of muscle involvement, but the secondary eye muscle is the most involved, accounting for more than 90%, followed by the bulbar muscle, and then the neck, shoulder girdle, upper extremity, trunk, and lower extremity muscles, or the whole body muscle is involved at the same time.

Patients with myasthenia gravis should eat delicious and appetite-enhancing meals and vegetarian food, while patients with myasthenia gravis can eat fruits (apples, grapes, etc.) after meals, and natural beverages such as fruit juice without any additives are appropriate, and patients with myasthenia gravis should use less soda and other beverages that are easy to cause stomach acid. Patients with myasthenia gravis can choose vegetables and fruits rich in vitamins E, C, A, and B, such as radish, bean sprouts, seaweed, onions, kelp, fungus, dried fruits (chestnuts, walnuts, almonds, sunflower seeds), strawberries, black plums, bananas, and tomatoes, oranges, cucumbers, etc. containing salicylic acid.

Myasthenia gravis is an autoimmune disease in which transmission is impaired at the neuromuscular junction due to a decrease in acetylcholine receptors. The main clinical feature is that local or generalized striated muscles tend to fatigue and weakness during activity, which can be relieved by rest or anticholinesterase drugs. It can also involve myocardium and smooth muscle, presenting with corresponding visceral symptoms.

There may be a family history of myasthenia gravis (familial hereditary myasthenia gravis).

Myasthenia gravis includes the nerves of the muscle junction part, obstruction of the production of immune antibodies, malnutrition, fatigue, surgery, etc. Myasthenia gravis is a common autoimmune disease with insidious onset and prolonged disease, which is more difficult. If certain measures are not taken in time, it will lead to the gradual increase of the disease, which will bring great harm to people.

Q: Can myasthenia gravis**?

In my lecture I just said, myasthenia gravis is a treatable disease, but I didn't use the word "a**". Why? There is a difference.

Treatability refers to the fact that the patient can be kept in a relatively normal state after passing the medical and surgical procedures, but if the drug is withdrawn, the patient may have a recurrence. So he needs long-term medication and is a chronic disease. And if you can, it means that the patient can completely stop the drug.

The myasthenia gravis of the juvenile eye muscle type we mentioned earlier has 1 3-1 4, which can reach a ** state. But who can reach **, we don't yet have the scientific means to be able to identify them at an early stage.

Myasthenia gravis may occur if not timely. Myasthenic gravis crises are usually divided into 3 types:1

Myasthenic crisis is clinically manifested by the sudden aggravation of the patient's muscle weakness symptoms, weakness in swallowing and sputum production, dyspnea, often accompanied by irritability, sweating profusely and other symptoms. 2.Cholinergic crisis is seen in patients who have taken a large dose of "pyridostigmine bromide" for a long time, or take too much for a while, and often show nausea, vomiting, abdominal pain, diarrhea, sweating, tearing, clammy cold, increased oral secretions, fasciculations, emotional agitation, anxiety and other psychiatric symptoms before the crisis.

3.The dose of pyridostigmine bromide remained unchanged in the anti-repulsive crisis, but the drug suddenly became ineffective and severe dyspnea developed. It can also be due to infection, electrolyte imbalances, or other unknown causes.

Myasthenia gravis may cause the following conditions:

First, myasthenic crisis, which includes cholinergic crisis, reflux, etc. If it is not timely, it may eventually cause dyspnea, suffocation and death, and you should go to the hospital in time to see if you are sick, and you need to save your life through mechanical respiration.

Second, if the muscle weakness involves the laryngeal muscles, it will affect the patient's swallowing function, which may lead to the involuntary suction of the pulmonary infection, and the patient needs to be given active anti-infection and symptomatic treatment**.

Thirdly, trauma, when the disease occurs, the patient will experience extreme fatigue and weakness of the muscles of the whole body. If you have a seizure while walking, you may be injured. If it occurs while driving or working at height, it can even be life-threatening.