What causes severe muscle weakness?

1. The cause of myasthenia gravis is related to acetylcholine receptors, which further activate the mitochondria in muscle cells, thereby completing the contraction of muscles, executing exercise instructions, and inhibiting the perception of myasthenia gravis is one of the causes of myasthenia gravis.

2. The reason for myasthenia gravis is that it hinders the normal combination of acetylcholine and acetylcholine receptors, thus inducing the inability to effectively issue motor instructions, resulting in the emergence of myasthenia gravis.

3. The cause of myasthenia gravis is composed of the postsynaptic muscle cell membrane and the synaptic space between the two. A motor command is activated when it is passed down from a presynaptic motor nerve ending. Myasthenia gravis is caused by the release of the chemical transmitter acetylcholine into the synaptic cleft by synaptic vesicles, which move through the gap to the postsynaptic muscle membrane and the postsynaptic muscle cell membrane.

4. The cause of myasthenia gravis is familial hereditary, and in recent years, many autoimmune diseases have been observed and found that they are not only related to often histocompatibility antigen complex genes but also incompatible antigen complex genes, such as T cell receptors and immunoglobulins, cytokines and apoptosis genes.

5. External environmental factors, such as environmental pollution, can bring about a decline in the immune system, and overwork can cause the body's immune function to be disordered. Viral infections or the use of certain antibiotic drugs can induce certain genetic defects.

6. The patient's own immune system is abnormal, and clinical observation shows that many immune indicators in patients with myasthenia gravis are abnormal, and the clinical symptoms disappear after diagnosis and treatment, but the abnormal immune indicators do not change, which may be an important factor in the instability of myasthenia gravis and easy to attack.

The above are the main factors that cause myasthenia gravis, and I believe that everyone should have an understanding of the knowledge of myasthenia gravis in this regard. If you have any other myasthenia gravis problems that you would like to consult, you can consult a specialized hospital. I wish you good health.

The most common presenting symptoms of myasthenia gravis are ptosis and diplopia in both eyes. Patients may also have muscle weakness in the extraocular muscles, laryngeal muscles, or extremities alone at the beginning of the disease. This is followed by the gradual involvement of more skeletal muscles, from the face and limbs to the respiratory muscles, affecting normal life and even life-threatening.

Typical symptoms. The main symptoms are as follows:

Ptosis is caused by paralysis of one or both extraocular muscles, which may be accompanied by strabismus and diplopia, and in severe cases, eye movements are significantly limited, or even the eye is fixed, but the pupillary sphincter is not affected, that is, the pupillary accommodation function is normal;

Dysphagia and chewing: This is caused by the involvement of the facial and throat muscles, and at the same time, there will be an indifferent expression, a wry smile, continuous chewing weakness, choking on water, and more laborious swallowing of chewed food when eating;

Hoarseness: This is also caused by the involvement of the facial and throat muscles, which can be accompanied by nasal speech, dysphonia, and unclear pronunciation when speaking;

Difficulty raising head: when the sternocleidomastoid muscle and trapezius muscle are involved, it manifests as neck weakness, difficulty in raising the head, weakness in turning the head and shrugging the shoulders;

Weakness of the arms and legs: The muscles of the limbs are affected by proximal weakness, which is manifested as difficulty in raising the arms, combing the hair, and climbing stairs, but the tendon reflexes are usually unaffected and the sensation is normal;

Dyspnea: Respiratory muscle involvement often leads to adverse consequences, and medical attention should be sought as soon as possible if you experience difficulty breathing;

Morning and evening severity: this is a characteristic of the symptoms of the disease, i.e., daily fluctuations, muscle weakness that worsens after exertion in the afternoon or evening and lessens after morning or rest.

In some patients, when the respiratory muscles are affected, the generalized muscle contraction weakness or even muscle weakness occurs in the short term. Myasthenic crisis refers to the dangerous phenomenon that the patient suddenly develops severe dyspnea under the influence of a certain trigger, and the patient is unable to breathe normally. Once it occurs, patients need to be presented to the emergency department quickly, and myocardial involvement can occasionally occur, which can lead to sudden death.

Predisposing factors include respiratory tract infections, surgery (including thymectomy), stress, and systemic disease

Symptoms of myasthenia gravis, manifested by neuromuscular conduction disorders involving generalized skeletal muscles. Weakness is manifested as fatigue, exertion and rest, and skeletal muscle weakness is generally severe in the morning and evening. Depending on the muscle group affected, there may be different presentations.

Lesions involving the levator palpebrae muscle may cause drooping eyelids, and the eyelids become smaller and smaller when the eyes are opened to see things, and finally they may not be able to open at all. After closing the eyes and resting, they can be opened again, and the eyelids can be lifted to look up and down, left and right, and double vision and eye movement disorders may occur, which is a condition that affects the extraocular muscles. Facial expression muscles are affected, and weakness of eyelid closure may occur, and slowness may occur when grinning teeth.

The patient has a wry smile due to impaired levator labial activity, and the corners of the mouth droop down when he smiles. If the swallowing and masticatory muscles are affected, eating and eating may be difficult. At the beginning of the swallowing and chewing function is acceptable, but gradually chewing and swallowing difficulty, you may eat smoothly in breakfast, and your strength weakens at lunch and dinner.

The amount of food you eat is the same as before, but the time is getting longer, you need to rest before eating, and the amount of food you eat is also reduced when the time is extended. Patients may also have difficulty speaking, speaking a text or reading a book at the beginning of the spell clearly, gradually unable to bite the words clearly, and after resting can say a few more words. The muscles of the limbs are affected, and the hands are raised flat for a while and then fall off, and the hands are raised flat for less than two minutes.

The most prominent feature of muscle weakness is the extreme fatigue of the affected bone muscles, which recover to varying degrees after rest. The condition fluctuates, day by day. Many episodes are insidious, often starting with one group of muscles and progressively affecting other groups.

Cranial innervation muscles were the most common first, with drooping eyelids and diplopia accounting for more than 90% of the first symptoms, followed by bulbar muscles and limb girdle muscles.

Drooping eyelids and inability to lift eyelids. According to the analysis of MG cases, ptosis was the first symptom in 73% of patients. It can occur at any age, especially in children.

Myasthenia gravis is mostly on one side in the early stage and on both sides in the late stage, and many patients have left and right eyelids that are alternating when one eyelid is stared up, and the other eyelid is drooping again.

Dyspnea: This is one of the most severe symptoms of myasthenia gravis, which can kill the patient in a short period of time, so it is also called myasthenic gravis crisis. This is due to severe weakness of the respiratory muscles. The patient has difficulty breathing and cannot lie down at night, so he can only sit and breathe.

Nasal speech, hoarseness: as if you have a cold or flu. Some patients speak or read the newspaper in a meeting, and their voice is okay for the first few minutes, but after a long time, their voice becomes hoarse and low, and finally they can't make a sound at all.

It's okay at the beginning when you hit **, but after a long time, others can't hear what he says.

Let's use Chinese medicine to do it! Stay away from hormones***. Scattered!! Six-rate six!! Nine 9!! Five, five, five.