What are the main causes of gout? What is the cause of gout

Cause. 1. Obesity:

People with superior dietary conditions are susceptible to gout. It has been found that the average body weight of patients with gout exceeds the standard body weight, and the higher the body surface area, the higher the serum uric acid level. In obese patients, blood uric acid levels can decrease when they lose weight.

This suggests that long-term excessive intake is associated with overweight and persistently elevated serum uric acid levels.

Cause. 2. Drinking:

When alcohol is metabolized in liver tissue, a large amount of water is blown to strengthen the blood concentration, so that the uric acid, which is close to saturation, accelerates into the soft tissue to bring crystals, induces the body's immune system to overreact, and brings inflammation, which is one of the more common causes of gout.

Cause. 3. Excessive pressure:

The huge pressure of work and excessive mental tension lead to psychosomatic fatigue and lack of exercise, which will reduce the physiological function of various organs, damage the excretion of metabolic wastes, and make body fluids acidic, which is the root cause of gout and one of the most important diseases of gout.

Cause. 4. Hyperlipidemia:

About 75% to 84% of patients with gout have hypertriglyceridemia, and some have hypercholesterolemia. In order to alleviate the condition, gout patients should lose weight, play a physiological weight standard, appropriately suppress diet, and reduce hyperlipidemia, which is the first cause of gout.

Cause. 5. High blood pressure:

The prevalence of gout in patients with hypertension is 12% to 20%, and about 25% to 50% of patients with gout have concomitant hypertension. Among the unqualified hypertension patients, about 58% of them have high blood uric acid, so it is necessary to do a good job in preventing gout.

Gout is a joint disease caused by the deposition of urate in the joints due to a disorder of purine metabolism or decreased uric acid excretion.

Gout can be primary or secondary and can be associated with obesity, alcohol consumption, high blood pressure, high blood sugar, excessive consumption of purine-rich foods and medications, etc. It is more common in middle-aged and elderly people with metabolic syndrome, and it is more common in men than women. Gout most commonly occurs in the first metatarsophalangeal joint, followed by the dorsum of the foot, ankle, heel, knee, wrist, fingers, elbow, etc.

Gout often manifests as sudden joint pain, redness, swelling, fever, and limited movement at night or early in the morning.

The **methods of gout are mainly general** and drug**, and the prognosis is relatively good after early positive**.

If the disease is not actively delayed, it may lead to joint deformity and loss of joint function. It can cause gouty nephropathy, uric acid nephrolithiasis, acute renal failure and other kidney damage.

Gout is due to abnormal phlegm metabolism in the body, resulting in excessive production of uric acid, accumulation of diseases caused by swelling and pain in the body, joints, need to be active **In this case, first of all, eat less protein-rich foods such as seafood tofu, do not drink alcohol, reduce the production of uric acid, and then increase uric acid excretion. This pain is apparently treated with non-steroidal anti-inflammatory drugs**.

There are many causes of gout, such as genetics, overwork, poor eating habits, and lack of warmth in the limbs. In addition, disorders of purine metabolism in the body can also cause gout. Recommendations:

In terms of diet, do not eat animal offal, because animal offal is a high-purine food, which will increase the body's metabolic disorders.

Gout is mainly caused by kidney disease, medications, tumors, chemotherapy and radiotherapy, etc. Acute arthritis is an inflammatory response due to the deposition of urate crystals, which leads to mononucleation over a long period of time.

The cause of gout is generally caused by the accumulation of uric acid is too high, when the kidneys excrete uric acid abnormally, there will be uric acid accumulation in the muscles and joints to produce gout symptoms, you can first use some uric acid reducing drugs to regulate, you can also choose antipyretic analgesics to relieve the pain symptoms of local joints, usually we must pay attention to drinking more water, which can be conducive to the excretion of uric acid.

1.Lack of attention to keeping joints warm on a daily basis, especially in cold and damp weather.

2.Heavy alcohol consumption, especially liquor and beer, can lead to an increase in the level of uric acid in the body, which can induce gout.

3.Eat plenty of foods that are high in purines. Such as animal offal, thick broth, hot pot, skewers, oysters and other seafood.

4.Trauma and frequent late nights and irregular work and rest can also induce gout.

5.Genetic factors. That is, there is a family history of gout.

Genetic factors associated with hyperuricemia: although only about 20% of patients with hyperuricemia will develop gout, hyperuricemia remains the most important risk factor for gout. Genetic factors associated with gout:

The activation of the natural immune system is the main mechanism of hyperuricemia leading to gout, and congenital abnormalities in the inflammatory pathway caused by leukocyte phagocytosis of urate crystals are important causes of gout attacks. People who regularly overeat high-purine, high-protein, high-fat foods and drink a lot of alcohol for a long time are susceptible to gout. According to the statistics of doctors, the incidence of gout in people who have a constant feast is 30%, and the incidence of gout is also more in those who often eat hot pot;

Gout is mainly a disease caused by excessive purine metabolism in the body, the main organism produces too much purine, often eats some seafood in ordinary life, has the habit of alcoholism, etc., will cause the body to produce too much purine to cause the symptoms of gout, in addition, the body's kidney function problems lead to the inability of purine metabolites to be discharged in time will also cause the symptoms of gout. Gout often has a family history of hereditary history, and people with superior dietary conditions are susceptible to this disease, and the incidence of gout is affected by region, age, and ethnicity, etc., and the prevalence rate is usually slightly higher in coastal areas. In addition, patients are often obese, often accompanied by hyperlipidemia, hypertension, diabetes, arteriosclerosis and coronary heart disease.

Therefore, it is generally believed that the onset of gout is also related to insulin resistance. Patients with gout must pay attention to diet moderation, strictly abstain from alcohol, drink more water, lose weight, and avoid triggers.

The ** that causes gout is not completely clear, it is related to diet and purine metabolism in the body, eating a high-purine diet will lead to an increase in blood uric acid in the body. Hyperuricemia is the most important biochemical basis for the occurrence of gout, or the abnormal metabolism of purines in the body caused by some reason, producing too many purines, or too many purines are deposited in the body and cannot be excreted, then it will lead to hyperuricemia in the body, which is also a major cause of gout. The main reasons for abnormal purine metabolism in the body are:

For example, blood disease, or chronic kidney disease, or it may be related to certain medications. Therefore, the causes of gout so far are varied, and may be related to diet and purine metabolism.

With the improvement of people's living standards and dietary structure in recent years, the incidence of gout has increased year by year. It is associated with excessive consumption of high-purine foods and decreased renal excretion of uric acid. 90% of the body's uric acid is excreted through the kidneys, and various kidney diseases and other diseases that cause abnormal kidney function, such as hypertension, diabetes, immune system diseases, drug-induced kidney diseases, etc., will affect the kidneys and lead to the occurrence of hyperuricemia.

Secondly, congenital ** causes abnormalities in the purine metabolism process, such as congenital polycystic kidney and congenital solitary kidney, which can cause uric acid to accumulate in the body. When a large amount of high-purine cinnaphozol food, excessive exercise, and exposure to cold, it is easy to cause uric acid to accumulate in a certain joint, and eventually induce the attack of gout.

Gout is one of the more common diseases in our body, and gout generally occurs in the elderly in China, which should be related to their physical fitness. There are many reasons for gout, which is also related to the quality of the human body, let's take a look.

1. Heredity

The incidence of gout is genetically related, but it is rare for a clearly hereditary disease, accounting for only 1% to 2%. Examples include self-disfiguring syndrome and glycogen accumulation type I. Common'The types of inheritance are X-linked recessive inheritance, autosomal recessive inheritance and polygenic inheritance, most of which are polygenic inheritance.

2. Obesity

Obesity is also the most common genre of gout. Gout is often referred to as "rich and sick, and it tends to occur in obese middle-aged men over 40 years old, especially those who do not like to exercise, eat more meat and protein, and are overnourished." It is often complicated by hyperlipidemia (high triglycerides) and hypertension.

Therefore, in terms of the incidence of gout, obese people are higher than thin people, overnourished people are higher than average nutrition, and middle-aged and elderly people are higher than young people.

3. Life is irregular

Some young people live irregularly, often staying up all night. This irregular lifestyle will disrupt the rhythm of the human body's "biological clock", metabolize abnormalities, aggravate the acidification of the body, and become the object of gout's "favor".

In addition to paying attention to diet, gout patients can also drink more anti-hum acid-reducing liniment, which helps to excrete uric acid in the body, control and reduce the level of uric acid in the body, and is very helpful in reducing gout attacks.

Therefore, through the detailed introduction of gout in the above article, most people must have a large understanding of the causes of gout. By understanding, we will find that the causes of gout are generally: genetics, obesity, irregular life, etc., knowing this has a certain auxiliary effect on the future gout patients.

The most common causes of gout (high blood uric acid) in patients are as follows:

1. Genetic factors: gout is a common metabolic disease, and family members have a certain genetic predisposition;

2. Dietary habits: As a metabolic disease, gout is related to the patient's dietary metabolism and lifestyle habits. Most patients like to eat too much high-purine foods such as animal offal and seafood, and love beer and high-sugar drinks for a few minutes.

3. Other diseases: gout is mostly associated with long-term smoking, taking diuretics and other drugs, or chronic diseases such as diabetes, high blood, obesity and high blood lipids. Gout attacks occur when patients with hyperuricemia are affected by factors such as excessive exercise, trauma, low water intake, or even cold (more commonly after consuming more high-purine foods).

Therefore, whenever there is an acute attack of gout, it is necessary to analyze the specific cause and carry out targeted treatment.

With the gradual improvement of people's living standards, the incidence of gout patients is also gradually increasing. What are the main causes of gout? The pathogenesis of gout is not well understood so far, but hyperuricemia is the most important biochemical basis of gout.

A purine substance normally contained in human tissues. In addition, purines are also found in many foods, which are produced when purines in the body and in the food eaten are broken down.

Gout may be caused by some non-pathological factors, such as excessive obesity and heavy alcohol consumption, and long-term consumption of high-purine foods or excessive mental stress can also lead to the occurrence of gout. However, it cannot be ruled out that it is caused by pathological factors, and the patient may have genetic mutations or worsening hyperlipidemia.

First of all, obesity is the main cause of gout, obesity will increase the fat content in the body, which is not conducive to metabolism, and will lead to less uric acid excretion, which will form gout in the long run. Secondly, drinking alcohol for a long time without moderation can also cause symptoms, alcohol is rich in purines, and too high purines in the body will cause abnormalities in the body. Alcohol has a promoting effect on uric acid.

The cause of gout is abnormal purine metabolism, and patients with gout often experience a series of conditions such as inflammation and swelling of the affected area, which is accompanied by pain. The occurrence of gout is related to poor lifestyle and eating habits, if you usually eat more pork, beef, mutton and other foods with high bleaching content, or often drink alcohol, it is easy to cause gout.

What are the main causes of gout? 1. The prevalence of blood uric acid level and HUA in hypertensive patients was significantly higher than that in non-hypertensive patients. Hypertension is an independent risk factor for gout attacks.

Follow-up of U.S. residents for up to 9 years found that participants with hypertension had a significantly higher risk of developing gout than those without hypertension. 2. Hyperglycemia Hyperglycemia is a risk factor for HUA. In diabetic patients, purine catabolism is enhanced, uric acid production is increased, and blood uric acid level is increased, while HUA can aggravate kidney damage, reduce renal uric acid excretion, and further aggravate the occurrence and development of HUA.

However, changes in blood glucose and serum uric acid levels are not linearly correlated. 3. Obesity is a risk factor for gout, obesity not only increases the risk of gout, but also the age of onset of gout in obese patients is earlier. With the increase of BMI (body mass index), the incidence of gout increases significantly, and visceral fat is also closely related to the occurrence of gout.

4. Excessive alcohol intake is an independent risk factor for gout attacks. Beer contains a lot of purines, so it has the greatest risk of inducing gout.