What are the causes of muscle atrophy What are the common first symptoms of muscle weakness Thank yo

Common causes of neurogenic muscular atrophy are disuse, dystrophy, ischemia, and toxicity. Anterior horn lesions, nerve roots, plexus, and muscle atrophy lesions of peripheral nerves can cause conduction disorders of nerve excitatory impulses, so that some muscle fibers are disused and disuse amyotrophy is produced.

On the other hand, after any part of the motor neuron is damaged, the release of acetylcholine from its terminal part decreases, and the sympathetic nerve nutrition is weakened, resulting in muscle atrophy. Myogenic muscular atrophy is caused by a disorder of the muscles themselves, and may also include other factors, such as muscular dystrophy in patients with shoulder girdle or faciculoscapulohumeral type, confirmed by morphological examination.

Myasthenia manifests as systemic musculoskeletal muscle involvement, but extraocular muscle involvement is the most common. Extraocular muscle involvement is manifested as drooping eyelids, diplopia, etc., or the whole body muscles are affected at the same time, which is aggravated after fatigue, and partially recovered after rest. The extent and extent of the affected muscles vary widely.

There are many reasons for muscle atrophy, which can be roughly divided into disuse atrophy and atrophy caused by damage to God, the former can be recovered by strengthening exercise, and the latter needs to be active.

There are two causes of muscle atrophy: neurogenic and myogenic ones.

Patients with muscle weakness should be aware of the following diseases:

The first situation may be myasthenia gravis, myasthenia gravis is a disease of the neuromuscular junction, which is also an autoimmune disease, the patient will have muscle weakness, the symptoms are relatively mild when he gets up in the morning, and will be aggravated in the afternoon, and it will be aggravated after exercise, and it can be relieved by rest, it is recommended to improve the relevant antibody tests and electromyography examinations.

In the second case, muscle weakness occurs, if it is accompanied by muscle atrophy and flesh beating, it is a motor neuron disease, which is a neurological degenerative disease, and the prognosis is relatively poor.

Third, if there is muscle weakness, it may be polymyositis, and patients with polymyositis are often accompanied by muscle soreness.

Muscular atrophy mainly refers to a series of clinical diseases such as the reduction of the volume or volume of the corresponding muscles caused by various reasons, which causes a series of clinical diseases such as muscle strength loss, which actually causes muscle atrophy. For the common clinical manifestations of muscle atrophy, the main is that the atrophied muscles appear smaller in volume or volume, and produce some deformities of the limbs, if the muscles of the limbs are atrophied, the limbs will be thinner, the deltoid muscle atrophy will appear obvious square shoulder deformity, the normal roundness of the shoulder joint will disappear, the atrophy of the hand muscles will appear flattened of the hand, and if the atrophied muscles are more obvious, the corresponding muscle strength will also decrease.

Muscle atrophy of the lower limbs can cause weakness in walking, inability to stand, inability to squat, inability to step, etc., and muscle weakness in the hand can cause abnormalities in some movements of the hand, such as inability to make fists, inability to do some fine movements, etc., and significant weight loss. It will also lead to some accompanying symptoms due to common reasons, such as muscle atrophy caused by neurogenic disease, in addition to muscle atrophy in the corresponding innervation area, there will also be paresthesia, such as decreased sensation and weakness, ant crawling sensation, etc., if it is myogenic muscle atrophy, there can be local muscle pain and soreness, muscle atrophy is often a more serious disease manifestation, should be checked and diagnosed in the hospital as soon as possible.

1. Acute or subacute muscular atrophy.

It is generally neurogenic atrophy, and the rate at which it occurs is related to the rate and extent of nerve damage. The more acute and severe the nerve damage and disruption, the faster and more pronounced the amyotrophy will occur. Amyotrophy occurs after paralysis at the time of acute onset, and the clinical manifestations of paralysis are the mainstay, such as polio, peripheral neuritis, Guillain-Barré syndrome, alcoholism, etc.

Neuralgic muscular atrophy is characterized by severe pain near the scapula in the early stages, followed by decreased muscle tone, paralysis, and muscle atrophy near the scapula, and in some muscle groups a single mosaic pattern.

2. Progressive distal limb muscle atrophy.

It is often neurogenic muscular atrophy, mainly in the distal limbs, the upper limbs are in the interosseous muscles of the hands, the thenar muscles are more obvious, and the lower limbs are more obvious in the tibialis anterior muscles. The two sides are basically symmetrical, often preceding paralysis, and are a single symptom. Common diseases include amyotrophic lateral sclerosis and progressive spinal muscular atrophy due to motor neuron disease, and weakness and muscle atrophy of the distal upper extremities due to cervical spondylosis.

Gastrocnemius muscular atrophy is characterized by muscle atrophy bounded by 1 or 3 lower thighs of the lower limbs, accompanied by sensory and superficial sensory deficits, and sensory ataxia. In addition, syringomyelia, spinal cord vascular malformations, leprosy, and chronic anterior horn polio can cause progressive muscle atrophy of the distal extremities. Atrophic myotonic and distal progressive muscular dystrophy in myopathy also present with amyotrophy of the distal extremities.

3. Progressive proximal muscle atrophy of the extremities.

It is often myogenic atrophy, which is evident in the proximal extremities and trunk muscles, and often manifests as atrophy and weakness of the scapular girdle and pelvic girdle muscles. For example, if the neck muscles are weak, some people need to use hand support to lift their head. The muscles of the scapula atrophy form the winged scapula.

Atrophy and weakness of the girdle muscles in the pelvis form a specific 'duck gait'.

Muscle atrophy and muscle weakness are not the same, if you don't exercise for a long time, it will cause muscle atrophy, muscle weakness is an electrolyte disorder, and it will also cause a lack of blood supply in serious cases.

Patients with myasthenia gravis may have muscle atrophy, which is usually disuse muscle atrophy. If the patient is in a resting state, the muscles will atrophy in a week, and patients with myasthenia gravis will have weakness in the limbs and limited activities due to the influence of the disease, which will affect the patient's activities. As a result, these patients experience muscle wasting.

Patients with myasthenia gravis need to be actively given immunosuppressants, hormones, immunoglobulins and other drugs, and further improve the relevant examination of the thymus. Most patients with myasthenia gravis will require oral medications to improve their symptoms, and a small number of patients may get **.

Severe myasthenia gravis will lead to muscle atrophy, and if you can't control the condition in time, it will lead to serious consequences of the condition. It is advisable to go to the hospital** to avoid excessive fatigue; Drugs that interfere with neuromuscular transmission should not be used, and there are also drugs that relax various muscles.

Myasthenia gravis muscle atrophy is possible, but not every patient with myasthenia gravis will have muscle atrophy, and the cause of myasthenia gravis is generally congenital hereditary and rarely unrelated to autoimmunity. The onset of this disease is generally thought to be related to infections, drugs, and environmental factors.

The main symptoms of typical symptoms are reflected in the following aspects: ptosis: this is caused by paralysis of one or both extraocular muscles, which may be accompanied by strabismus and diplopia at the same time. Difficulty swallowing, difficulty chewing:

This is caused by the involvement of the facial and throat muscles, and at the same time, there will be an indifferent expression, a wry smile, continuous chewing weakness, choking on water, and more laborious swallowing of chewed food when eating; Hoarseness: This is also caused by the involvement of the facial and throat muscles, which can be accompanied by nasal speech, dysphonia, and unclear pronunciation when speaking; Difficulty raising head: when the sternocleidomastoid muscle and trapezius muscle are involved, it manifests as neck weakness, difficulty in raising the head, weakness in turning the head and shrugging the shoulders; Weakness in the arms and legs

Proximal weakness is the most important aspect of limb muscle involvement, which is characterized by difficulty raising arms, combing hair, and climbing stairs, but on examination by a doctor, tendon reflexes are usually unaffected and sensation is normal; Dyspnea: Respiratory muscle involvement often leads to adverse consequences, and medical attention should be sought as soon as possible if you experience difficulty breathing; Morning and evening severity: this is a characteristic of the symptoms of the disease, i.e., daily fluctuations, muscle weakness that worsens after exertion in the afternoon or evening and lessens after morning or rest.

In some patients, when the respiratory muscles are affected, the generalized muscle contraction weakness or even muscle weakness occurs in the short term. Myasthenic crisis refers to the dangerous phenomenon that the patient suddenly develops severe dyspnea under the influence of a certain trigger, and the patient is unable to breathe normally. Once it occurs, patients need to be presented to the emergency department quickly, and myocardial involvement can occasionally occur, which can lead to sudden death.

Predisposing factors include respiratory tract infections, surgery (including thymectomy), mental stress, systemic illness, etc.

.This is not the same disease, it may be muscle weakness, it is not this muscle atrophy that causes muscle weakness, there may be other factors, after muscle atrophy, there may be other symptoms, in short, these two diseases will appear at the same time. Prompt identification and treatment is recommended.