What are the dangers of chronic sleep deprivation?

1. Temper tantrum: When people are focused on doing something, if they are interrupted due to unexpected interference, negative emotions will be generated; If you don't get enough sleep, this negative emotion will be amplified.

2. Headache: Scientists still can't find out the reason behind it, but 36 58% of people who don't get enough sleep will have headaches when they wake up.

3. Reduced learning ability: short-term memory is an important key to determining learning effectiveness, and people who lack sleep will have weakened short-term memory ability, which also affects the learning effect.

4. Weight gain: People who lack sleep will have hormonal imbalances in their bodies, not only will their appetite increase, but they will also want to eat high-calorie foods more, and their ability to control impulsive behaviors will also decrease, and these factors add up to lead to rapid weight gain.

Long-term sleep deprivation may lead to psychiatric diseases, endocrine disorders, and may even increase the incidence of cardiovascular and cerebrovascular diseases

1.Psychiatric diseases: If you don't get enough sleep for a long time, it may lead to mental trance, lack of energy, and most patients will also have insomnia and dreams, which will increase the incidence of mental breakdown, insomnia and other diseases.

2.Endocrine disorders: If they do not get enough rest, patients are prone to endocrine disorders, which are common in thyroid dysfunction, sex hormone disorders, etc.

3.Cardiovascular and cerebrovascular diseases: Prolonged lack of sleep will lead to damage to the heart, brain and other organs, affecting local blood circulation, and then increasing the incidence of myocardial ischemia, cerebral infarction and other diseases.

Nowadays, people's living conditions are getting better and better, and the development of mobile phones, televisions, computers and other technologies has brought great convenience to people, but at the same time, there are many people who will stay up late to watch TV, play games, etc., resulting in lack of sleep. And people will also find that lack of sleep and dizziness, what is going on? What should I do if I don't get enough sleep and feel dizzy?

What are the dangers of sleep deprivation?

Many young people feel that staying up late is nothing for them, after all, they are still young, this degree is still acceptable, but if long-term sleep deprivation will bring serious results, let's take a look at the harm of long-term sleep deprivation.

4 major dangers of chronic sleep deprivation.

1. It can lead to depression.

Over time, sleep deprivation and sleep disturbances can lead to depression. Insomnia and depression are inextricably linked. According to a survey of 10,000 people in '07, those with insomnia were up to five times more likely to develop depression than those without insomnia.

In fact, insomnia is often one of the precursors of depression. Insomnia and depression go hand in hand, with lack of sleep exacerbating depression, which in turn makes it harder to fall asleep. On the positive side, sleep problems contribute to the alleviation of depression and vice versa.

2. Accelerate aging.

Presumably most people have experienced sallow yellow and puffy eyes after a few nights without sleeping. But it proves that long-term sleep deprivation can lead to dullness, wrinkles, and dark circles. When you don't get enough sleep, your body releases more of the stress hormone cortisol.

Excess cortisol breaks down collagen, which keeps it smooth and elastic. Deep sleep repairs** tissues.

Poor memory, endocrine disorders, decreased resistance, mood swings, low learning and work efficiency.

Sleep is very important for our health, so do you know that long-term sleep deprivation can be harmful, and I will introduce you to long-term sleep deprivation. Hazards, everyone is welcome to read.

1. Emotional instability

People with chronic fatigue are emotionally unstable because sleep and mood are regulated by the same brain chemical.

2. Aging before aging

Hormonal changes during sleep promote blood flow, so sleep well and be brighter and more resilient.

3. Easy to gain weight

Chronic sleep deprivation can disrupt blood sugar levels, leading to changes in the body's levels of many hormones. These physiological changes inevitably lead to overeating. Tired people are particularly fond of sweets and other simple carbohydrates, probably because they fill their stomachs quickly.

4. It is easy to get diabetes

Studies have found that 6 days of sleep deprivation can lead to insulin resistance. However, those who slept less than 6 hours a night were unable to metabolize sugar normally, so the risk of developing type diabetes increased.

5. Stress hormone disorder

Studies have found that sleep deprivation can cause cortisol levels to peak in the afternoon and evening, making people more awake when they should be sleeping, which in turn increases the risk of high blood pressure, heart disease and type diabetes.

6. Resistance deteriorates

People who don't get enough sleep are more susceptible to diseases.

7. Slow response

People who lack sleep are sluggish, have difficulty concentrating, have slow reactions, and have worse motor skills. In addition, less sleep can lead to impaired balance and deep perception.

8. Increased risk of cancer

Sleep deprivation can lead to hormonal and metabolic disorders, which in turn increase the risk of cancer.

9. Pain

Chronic pain can cause tossing and turning at night, while sleeping too little can worsen the pain, creating a vicious cycle.

Humans spend a third of their lives sleeping, including invertebrates such as flies, worms, and even jellyfish. Throughout evolution, sleep has been universal and essential for all organisms with a nervous system. However, have you ever wondered why we sleep?

In fact, scientists have been searching for answers for years. According to a new study published in the journal Molecular Cell on November 18, researchers at Bar-Ilan University in Israel have found that the PARP1 protein in the brain acts as an "antenna" that sends time signals to the brain to sleep and repair DNA damage, a discovery that is one step closer to solving this mystery.

When we are awake, the homeostatic sleep pressure in the body increases, and the longer we stay awake, the more stress this stress increases. During the few hours of waking hours, factors such as ultraviolet light, neuronal activity, radiation, oxidative stress, etc., can cause sustained DNA damage in neurons. However, excessive DNA damage in the brain can be dangerous, and sleep can "summon" the DNA repair system.

The characteristics of neural activity during sleep in zebrafish are similar to those of humans, and they are the subjects of sleep study. Through zebrafish experiments, researchers determined that the accumulation of DNA damage is a driving factor that causes sleep states. When the accumulation of DNA damage reaches the maximum threshold, the homeostatic sleep stress increases to the point where the urge to sleep triggers it, and the fish goes to sleep.

Subsequent sleep promotes DNA repair, which reduces DNA damage.

So, what is the mechanism in the brain that tells us: it's time to sleep? The study found that the PARP1 protein is part of the DNA damage repair system and is one of the first proteins to respond quickly.

It flags the location of DNA damage in the cell and "recruits" all relevant systems to remove the DNA damage.

Through genetic and pharmacological manipulation, overexpression and knockdown (down-regulation) of PARP1 experiments have shown that increasing PARP1 not only promotes sleep, but also increases sleep-dependent repair. Conversely, inhibition of PARP1 blocks the signal for DNA damage repair. As a result, the fish are not fully aware that they are tired and therefore do not go into sleep mode, causing DNA damage to not be repaired in time.

The same results were validated in mice.

This new finding describes how to explain the "chain of events" of sleep at the single-cell level. This mechanism explains the link between sleep disorders, aging, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. The researchers believe that future research will be extended to more animals, from lower invertebrates to humans.

Reduced immunity: People who have not slept well for a long time will have their brain nerves affected, resulting in endocrine disorders, which will lead to a decrease in resistance.

Easy to forget: Many young people around us now forget what they do for a while, many of which are due to the lack of sleep after staying up late, resulting in poor concentration and inability to remember anything, which will cause memory loss in the long run.

Irritable: long-term insomnia and difficulty falling asleep will cause irritability, lack of concentration, and many people who get up in the morning have "wake-up gas" Many reasons are caused by insufficient sleep quality.

Health problems: When sleeping, our body is relaxed, and the organs can also be rested, metabolizing the body's garbage for a day, on the contrary, staying up late and insomnia will cause disorders in the body's internal environment and intestinal flora imbalance, which is also one of the main reasons for a chronic disease.

Deterioration: Long-term lack of sleep also makes ashen and dark, and the water retention becomes poor, accelerates aging, forms pigmentation, and melanin deposition, and people look particularly old, and this condition is very difficult to improve.