Why is uric acid high? Why is uric acid high?

Uric acid above normal is generally considered to be the possibility of gout. It is a metabolic disease. If left uncontrolled, it can lead to problems in all systems throughout the body.

**Includes: Diet**Foods containing high purines should be avoided. Animal offal, bone marrow, seafood and other purines are the most abundant; Fish and shrimp, meat, peas, spinach, etc. also contain certain purines; Fruits, vegetables, milk, eggs, etc. are purine-free.

It is advisable to drink plenty of water to facilitate the excretion of blood uric acid from the kidneys. If symptoms are still not controlled, drugs that lower blood uric acid such as allopurinol can be used, and non-systemic antirheumatic drugs such as indomethacin and ibuprofen can be used to relieve joint pain symptoms.

This is the first thing you need to control your diet, but it doesn't mean that you can control your diet.

**In case of high uric acid, you can eat more daylily.

In recent years, we have paid more and more attention to the problem of uric acid, which is known as the fourth highest, which can induce the appearance of gout. We have uric acid in our body, and we will produce and metabolize uric acid every day, so our body is in a state of balance.

Why is uric acid high?In order to ensure that people are healthy, we must develop the habit of going to the hospital for regular medical check-ups. Some units and companies will organize everyone to conduct a physical examination, which includes the examination of urine. When we take a urine test, some friends who are not particularly healthy may experience high uric acid.

In the face of this situation, there is no need to be too nervous and worried, as long as you take relevant treatment drugs under the guidance and advice of your doctor, you can relieve the symptoms.

Why is uric acid high?Uric acid is a product of human metabolism and has a certain antioxidant effect on people. However, in the process of human evolution, uric acid will change with the change of dietary structure, which will lead to the inactivation of uricase and cause abnormal metabolism of uric acid, which is what we usually call the symptom of high uric acid. There are many reasons for high uric acid, and the most fundamental reason is physical factors.

Many people's physique is easy to lead to high uric acid, and they are also prone to symptoms of high blood pressure, high blood sugar and high blood lipids, which requires us to pay more attention to our diet. If you eat some seafood, spinach, and soy products in your diet, it will cause uric acid to rise.

The above is the relevant introduction to why uric acid is high. In addition to this, if there is a problem with our kidneys themselves, it can also lead to abnormal uric acid excretion, causing uric acid levels to rise. Therefore, we need to conduct a more comprehensive examination to determine the cause of high uric acid and prescribe the right medicine.

Why is uric acid high

When it comes to uric acid, everyone may be familiar with it, because high uric acid is often linked to gout, and high uric acid will lead to gout. Sakura disturbs.

Why is uric acid high

1. Diet

High uric acid has a lot to do with daily diet, in life, if you often eat some high-purine foods, such as seafood, red meat, and some animal offal, it is easy to cause a lot of physical conditions, so you should eat more fresh fruits and vegetables in life, when these foods contain some dietary fiber, vitamins and trace elements.

2. Moisture

If you drink less water in the usual chaos, it may lead to high uric acid, because the excretion of urine is too small, it may increase the content of some uric acid in the body, and at the same time, you may drink more alcohol in your life, which may also cause an increase in uric acid.

3. Stay up late

In life, if you often stay up late, do not pay attention to sleep, and are also very tired, and exercise less in life, it may also lead to an increase in uric acid, because at this time, the body's excretion is reduced, and the exercise metabolism and metabolism are relatively small, which will have a greater impact on the body, and in many cases he will have certain physical harm.

Why is uric acid high, he has to do with many reasons, so what everyone must pay attention to in life is to give yourself a better diet and some regularity of life and missing files.

Uric acid includes blood uric acid and uric uric acid, and high blood uric acid and uric acid may be caused by excessive intake of high-purine foods, decreased uric acid excretion, and excessive uric acid production. It is recommended to go to a regular hospital in time to find out the cause.

1. Intake of too much high-purine food: If the patient consumes too much animal liver, seafood, etc., it will increase the purine content in the body, resulting in high blood uric acid and urinary uric acid;

2. Decreased uric acid excretion: patients may have decreased uric acid excretion due to reduced glomerular filtration, decreased tubular secretion and other original factors, resulting in high blood uric acid and uric uric acid;

3. Excessive uric acid production: Excessive endogenous uric acid production is usually related to the defect of uric acid metabolizing enzymes and genetic variations, and the excessive production of uric acid in the patient's body may lead to high blood uric acid and uric uric acid.

The causes of high uric acid in the human body include improper diet, excessive uric acid production, uric acid excretion disorders, renal insufficiency, etc.

1.Caused by unreasonable dietary habits, such as patients eating too much food with high purine content, such as seafood, animal offal, boiled broth, beer, etc., are easy to cause an increase in uric acid in the body.

2.Excessive uric acid production in the body, generally more common in gout patients, is mostly hereditary, mainly related to the activity and concentration of various enzymes in the patient's body, resulting in excessive uric acid production in the patient's body.

3.Uric acid excretion disorder, decreased renal tubular secretion and increased reabsorption, resulting in uric acid can not be excreted out, resulting in increased uric acid.

4.Patients with renal insufficiency have an increase in uric acid due to the accumulation of uric acid in the body due to abnormal metabolic function of the kidneys in the body. High uric acid is caused by excessive uric acid production or decreased uric acid excretion.

Elevated blood uric acid refers to hyperuricemia, which refers to the uric acid content in the serum under the condition that the body temperature is 37 and the pH value of the blood is more than 420 mol L in men and 360 mol L in women.

The main reasons for the increase are: excessive production of blood uric acid, including excessive exogenous intake such as alcohol consumption (especially beer), excessive intake of meat and seafood (especially offal and seafood), and excessive intake of high sugar (such as carbonated drinks and fructose); In addition, due to genetic factors or environmental factors, these enzymes are deficient or underfunctional, purine metabolism is abnormal, and endogenous uric acid synthesis is increased. The second is the reduction of uric acid excretion.

Hyperuricemia can be divided into primary hyperuricemia and secondary hyperuricemia according to the cause of its onset.

The main reason for inducing gout is high uric acid, some patients may be caused by their own enzyme defects, and more patients are due to improper diet in their daily life, eating some foods with high purine content, resulting in high uric acid levels.

Diet high in gout uric acid:

1. Carbohydrate food: During the ** period, patients with high uric acid in gout in order to prevent the aggravation of the disease. You need to give your body the right amount of carbohydrates.

Since high uric acid in the body is also the cause of gout, it is necessary to find a way to lower uric acid, and acid-base neutralization is a good choice for lowering uric acid. Therefore, it is necessary to choose to infuse your body with a certain amount of carbohydrates.

2. Eat less purine-rich foods: such as eating less fish and crabs, autumn is the season when many seafood are on the market, and patients should not forget their symptoms because of greed. You must know that if a lot of uric acid cannot be metabolized in the body, urate crystals will be formed, which will cause gout.

Originally, gout, the "imperial disease", was caused by the "small problem" of "gluttony" in the final analysis.

3. Eat more rich in active enzymes: investigation studies have found that the proportion of male and female gout patients is 20 to 1, and the primary reason for the low incidence of gout in women is that estrogen in women's bodies can promote uric acid secretion and have the effect of alleviating arthritis pain.

High uric acid can lead to a range of complications, especially long-term hyperuricemia. The most common complications are gouty arthritis and gouty nephropathy, which are caused by acute or chronic inflammatory reactions caused by the deposition of urate crystals in the joints and kidneys.

Long-term hyperuricemia can lead to an increased incidence of hypertension and coronary heart disease. The main reason is that urate crystals can be deposited on the blood vessel wall, causing the elasticity of the blood vessel wall to deteriorate, thereby inducing an increase in the incidence of hypertension and atherosclerosis. Long-term hyperuricemia can also cause central nervous system lesions, usually affecting blood vessels in the skull.

Therefore, although hyperuricemia itself has no symptoms, it has a series of complications that are very terrible, once bone destruction and chronic renal insufficiency or hypertension have been caused, these lesions are irreversible. These conditions can only be prevented by aggressive lowering of serum uric acid at an early stage.

Causes gout attacks. Patients with high uric acid persist for a long time, and when a trigger point is touched, it first manifests as an acute gout attack, then transitions to chronic gout, and then forms tophi.

High uric acid is a metabolic disease caused by the metabolism disorder of purine substances in the human body, resulting in an increase in uric acid in the blood, the daily production and excretion of uric acid in the body are about equal, in terms of production, one-third is from food, two-thirds is synthesized by the body, one-third of the excretion route is excreted from the intestines, and two-thirds is excreted from the kidneys.

There are four main reasons for the increase in uric acid: the first is excessive consumption of high-purine foods; The second is that there is a problem with purine metabolism in the body; the third is that the amount of excretion is too low; The fourth is that uric acid cannot be excreted normally.

High uric acid may also be caused by excessive uric acid production or poor uric acid excretion, and various tumors can also cause uric acid to rise after chemotherapy and radiotherapy, thus causing hyperuricemia. In particular, patients with malignant tumors may have a marked increase in uric acid levels during chemotherapy, and renal insufficiency will reduce uric acid excretion, and uric acid levels may increase accordingly.

Uric acid is produced after the metabolism of purines in the body, if uric acid is found to be elevated during the examination, it is necessary to check whether there is a history of high-purine diet before the examination, such as whether you drank alcoholic beverages before the examination, or ate seafood, broth, animal offal or purine-rich meat. If the uric acid is not very high, you can strictly control the low-purine diet for 5-7 days and then retest, if the results of the re-examination are still relatively high, such as the blood uric acid of men exceeds 420umol l, it should be considered hyperuricemia. In addition to exogenous dietary factors, hyperuricemia may also be caused by endogenous purine metabolism disorders, and many patients with hyperuricemia have a family history, which can further clarify whether there is hyperuricemia or gout in the family.

In addition, there are some diseases that can also cause an increase in uric acid, such as kidney disease, which can cause a decrease in kidney function, which can lead to impaired uric acid excretion, causing secondary increase in uric acid. Long-term hyperuricemia has the risk of inducing gout and other diseases, so it is necessary to actively find out the cause of the increase in uric acid and target hyperuricemia**.

Why is uric acid high[High uric acid] is a metabolic disease caused by the increase of uric acid in the blood due to the metabolism disorder of purines in the human body. You can use Defu's Zifeng herbal tea to lower the uric acid value.

Causes] 1. The metabolism of purine substances in the body is disordered, resulting in an increase in the synthesis of uric acid.

1. Excessive intake of exogenous purines: The high content of uric acid is directly proportional to the purine content in food. 50% of the RNA and 25% of the DNA in the ingested food are excreted in the urine in the form of uric acid, and strict restriction of purine intake can reduce the serum uric acid content to 60 mol L (, and the secretion of uric acid in the urine decreases;

2. Excessive production of endogenous purines: endogenous purine metabolism disorders are more important than exogenous factors. The de novo synthesis of purines from acyclic to cyclic goes through an 11-step reaction, in which the abnormality of the enzyme will lead to excessive purine synthesis. The ones that have been found are:

1) Increased phosphoribose pyrophosphate synthase activity.

2) Hypoxanthine-guanine phosphoribosylating enzyme deficiency.

3) Glucose 6-phosphatase deficiency.

3. Increased purine metabolism: such as chronic hemolytic anemia, rhabdomyolysis, polycythemia, myeloproliferative diseases and high uric acid will be produced during chemotherapy or radiotherapy. Excessive exercise, epileptic states, and glycogen storage disease types III, V, and VII can all accelerate the degradation of ATP in muscles.

Myocardial infarction, smoking, and acute respiratory failure are also associated with accelerated degradation of APT.

2. The metabolism of purine substances in the body is disordered, resulting in a decrease in uric acid excretion, and 90% of patients with persistent high uric acid have abnormal function of renal uric acid processing.

With the decline of renal function, the secretion of uric acid per unit of glomerulus increases, but the secretion capacity of the renal tubules is basically unchanged, the reabsorption capacity of the renal tubules is also reduced, and the clearance capacity of extrarenal uric acid is significantly increased.

1. Inhibition of renal tubular secretion: one of the most important mechanisms. Uric acid excretion and/or reabsorption is increased due to inhibition of drugs, intoxication, or endogenous metabolites.

This occurs when the anion transport system is inhibited, and two of the important inhibitors are lactate and ketoacids.

2. Decreased glomerular filtration: it can also increase the level of uric acid. One of these mechanisms is a decrease in filtration rate, which is the main cause of hyperuricemia due to renal insufficiency or failure.

Increased net weight absorption of uric acid can occur in the setting of volume reduction, which is one of the mechanisms by which diuretics cause hyperuricemia.

3. Increased tubular reabsorption: hyperuricemia can also be caused by enhanced distal reabsorption from the secretory location. These can be seen when diabetes is dehydrated or diuretic**.

3. The coexistence of these two factors, in many patients, the two factors of increased uric acid production and decreased excretion are present at the same time.

Such as glucose 6-phosphatase deficiency, hereditary lactose intolerance patients. Alcohol can also retain uric acid in two ways. Excessive alcohol intake accelerates liver degradation of ATP and increases uric acid production.

Uric acid caused by alcohol also prevents the excretion of uric acid. Alcoholic beverages with a high purine content, such as beer, are also important factors.

Fourth, other external factors will also cause high uric acid.

Medications, climate, weather, etc.